![](images/graphics/blank.gif)
Activated CD4+
-
Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of AMPKα2 in the LIHC tumor immune environment is unclear.
17p
vikoch
27-06-2024
2
1
Download
-
Traditionally, the transcriptomic and proteomic characterisation of CD4+ T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and antibody-based cytometry.
22p
vibransone
28-03-2024
6
2
Download
-
Several cancer immunotherapies that target the PD-L1/PD-1 pathway show promising clinical activity in patients with hepatocellular carcinoma (HCC). However, the standard of care in first-line treatment with atezolizumab (anti-PD-L1 therapy) in combination with bevacizumab is associated with a limited objective response rate.
9p
vioracle
29-09-2023
7
3
Download
-
Polysaccharides have aroused considerable interest due to their diverse biological activities and low toxicity. In this study, we evaluated the effect of marine polysaccharide sulfated polymannuroguluronate (TGC161) on the leukopenia induced by chemotherapy.
12p
viginny
30-12-2022
7
2
Download
-
Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes.
19p
vialfrednobel
29-01-2022
6
0
Download
-
Sarcoidosis patients have accumulations of activated CD4+ T cells in affected organs, such as the lungs. T cell receptor (TCR) Vβ-chain usage has been incompletely characterized in these patients.
11p
vimontana2711
05-04-2021
18
1
Download
-
Ovarian carcinoma (OC) is the fifth most common female cancer and mostly diagnosed at an advanced stage. Surgical debulking is usually followed by adjuvant platinum-based chemotherapy. Only few biomarkers are known to be related to chemosensitivity.
9p
vibaku2711
22-07-2020
12
2
Download
-
The details of the immunological microenvironment and its clinical implications for pancreatic cancer are still unclear. In this study, we obtained data from public databases, such as the Gene Expression Omnibus, the Cancer Genome Atlas Program, the International Cancer Genome Consortium Data Portal, the ArrayExpress Data Warehouse, and the cBioPortal for Cancer Genomics. We used these data to evaluate the pattern of immune cells infiltration in pancreatic ductal adenocarcinoma (PDAC) tissues.
10p
partimesinhvien
08-05-2020
13
0
Download
-
The runt family transcriptional regulator, Runx3, is upregulated during the differentiation of CD8 single-positive thymocytes and is expressed in peri-pheral CD8 + T cells. Mice carrying targeted deletions in Runx3 have severe defects in the development and activation of CD8 + T cells, resulting in decreased CD8 + T-cell numbers, aberrant coexpression of CD4, and failure to expand CD8 + effector cells after activation in vivo orin vitro.
11p
galaxyss3
19-03-2013
33
2
Download
-
The HIV-1 encoded virus protein U (VpU) is required for efficient viral release from human host cells and for induction of CD4 degradation in the endoplasmic reticulum. The cytoplasmic domain of the membrane protein VpU (VpUcyt) is essential for the latter activity. The structure and dynam-ics of VpUcyt were characterized in the presence of membrane simulating dodecylphosphatidylcholine (DPC) micelles by high-resolution liquid state NMR.
16p
viettel02
20-02-2013
43
2
Download
-
Studies in the past quarter of century have established a role for lymphocytes in the pathogenesis of immune-mediated glomerular diseases. CD4- expressing T helper cells are a subgroup of T lymphocytes that provide help for immunoglobulin production and direct cellular immune mechanisms through activation of effector cells, such as macrophages. The role of T helper cells is variable depending on the nature of disease, and differential activation of T helper cell subsets has been proposed as one of the plausible explanations for the diversity of injury in glomerular diseases....
336p
kmkmkmkmkm
08-09-2012
52
5
Download
-
Humoral immunity is so named because it involves substances found in the humours, or body fluids. It is mediated by antibodies produced by cells of the B lymphocyte lineage. B cells, activated by the adaptive immune responses, transform into plasma cells which secrete antibodies. This process is aided by CD4+ T-helper 2 cells, which provide active co-stimulation. The secreted antibodies bind to antigens present on the surfaces of invading microbes, which marks them for subsequent destruction (Pier et al., 2004).
594p
wqwqwqwqwq
23-07-2012
53
6
Download
-
Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy
13p
dauphong3
03-01-2012
57
3
Download
-
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Anti-HIV-1 activity of salivary MUC5B and MUC7 mucins from HIV patients with different CD4 counts
9p
dauphong2
23-12-2011
44
2
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: T cell Activation does not drive CD4 decline in longitudinally followed HIV-infected Elite Controllers...
7p
toshiba23
18-11-2011
51
1
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Immune restoration disease and changes in CD4+ T-cell count in HIV- infected patients during highly active antiretroviral therapy at Zewditu ...
7p
toshiba23
18-11-2011
44
2
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Improving therapeutic HPV peptide-based vaccine potency by enhancing CD4+ T help and dendritic cell activation
10p
toshiba23
18-11-2011
47
2
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells...
9p
toshiba16
26-10-2011
39
1
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Reduced CD4 T cell activation and in vitro susceptibility to HIV-1 infection in exposed uninfected Central Africans...
9p
toshiba16
26-10-2011
45
2
Download
-
Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Endogenous TGF-β activation by reactive oxygen species is key to Foxp3 induction in TCR-stimulated and HIV-1-infected human CD4+CD25- T cells...
16p
toshiba15
25-10-2011
42
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)