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Acute myelogenous leukemia
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An elderly 72-year-old man presented with anemia, thrombocytopenia, monocytosis, splenomegaly and lymphadenopathy. Bone marrow biopsy was consistent with mast cell neoplasm with positive CD117, CD25, CD34 myeloblasts and polymerase chain reaction (PCR) revealed mutation of D816V. He developed bilateral femoral neck fractures and biopsy confirmed that he has systemic mastocytosis (SM).
3p
viintuit
26-09-2023
4
0
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Ophthalmic manifestations are common in patients with leukemia, developing in nearly 50% of cases. Intracranial hemorrhage is another potentially fatal complication of leukemia. In this case report, we aim to present a challenging case that involves both ophthalmic and intracranial manifestations in an individual with acute monocytic leukemia.
5p
videadpool
05-05-2023
4
2
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Myeloid sarcoma is a rare, extramedullary, solid tumor derived from immature myeloid cell precursors. It is most frequently accompanied by acute myelogenous leukemia, though infrequently found in non-acute myelogenous leukemia patients. The tumor may involve any part of the body, but the lumbar spine is seldom involved.
9p
vianttinic2711
20-04-2021
12
2
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Several acute lymphoblastic and myelogenous leukemias are correlated with alterations in the human mixed lineage leukemia protein-1 (MLL1) gene. MLL1 is a member of the evolutionarily conserved SET1 family of histone H3 lysine 4 (H3K4) methyltransferases, which are required for the regula-tion of distinct groups of developmentally regulated genes in metazoans.
11p
mobifone23
21-01-2013
44
3
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Pharmacokinetic targeting of intravenous busulfan reduces conditioning regimen related toxicity following allogeneic hematopoietic cell transplantation for acute myelogenous leukemia
9p
toshiba24
06-12-2011
46
2
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:Ring chromosome 18 abnormality in acute myelogenous leukemia: the clinical dilemma
4p
toshiba24
06-12-2011
44
3
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Lơ xê mi cấp (acute leukemia, AL) là nhóm bệnh máu ác tính của hệ thống tạo máu bao gồm lơ xê mi cấp dòng tuỷ (acute myelogenous leukemia, AML) và lơ xê mi cấp dòng lympho (acute lymphoblasic leukemia, ALL). Bệnh bắt đầu được mô tả từ đầu thế kỷ XIX và từ đó đến nay, đã có rất nhiều nghiên cứu về bệnh này [8]. Bệnh gặp ở mọi lứa tuổi, biểu hiện bệnh đa dạng, tỷ lệ bị bệnh cao. Tại Mỹ, hàng năm xuất hiện mới khoảng 2,2 trường hợp AML trên 100.000 dân và có...
17p
truongthiuyen19
08-08-2011
59
4
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Chronic Myelogenous Leukemia: Treatment The therapy of CML is changing rapidly because we have a proven curative treatment (allogeneic transplantation) that has significant toxicity and a new targeted treatment (imatinib) with excellent outcome based on 5-year follow-up data. Therefore, physician experience and patient preference must be factored into the treatment selection process. Discussion of both treatment options with a patient is indicated. The decision should focus on the outcomes, risks, and toxicities of the various approaches.
5p
thanhongan
07-12-2010
72
3
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Chronic Myelogenous Leukemia Incidence The incidence of chronic myelogenous leukemia (CML) is 1.5 per 100,000 people per year, and the age-adjusted incidence is higher in men than in women (2.0 versus 1.2). The incidence of CML increases slowly with age until the middle forties, when it starts to rise rapidly. CML incidence for males decreased slightly (4.4%) between 1997 and 2003 as compared to 1977–1997. Definition The diagnosis of CML is established by identifying a clonal expansion of a hematopoietic stem cell possessing a reciprocal translocation between chromosomes 9 and 22.
5p
thanhongan
07-12-2010
160
3
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Table 79-3 Representative Oncogenes at Chromosomal Translocations Gene (Chromosome) Translocation Malignancy ABL BCR (22q11) (9q34.1)– (9;22)(q34;q11) Chronic myelogenous leukemia ATF1 EWS (22q12) (12q13)– (12;22)(q13;q12) Malignant melanoma of soft parts (MMSP) BCL1 IgH (14q32) (11q13.3)– (11;14)(q13;q32) Mantle lymphoma cell BCL2 IgH (14q32) (18q21.
5p
konheokonmummim
03-12-2010
66
3
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