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Advanced biliary tract cancer
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Advances in the treatment of biliary tract cancer have been made possible through gains in genomic and epigenetic tumor understanding. The use of fibroblast growth factor receptor inhibitor has enabled significant clinical improvement in a specific group of patients with intrahepatic cholangiocarcinoma, some of whom with very durable responses.
7p
vitiki
30-01-2024
7
2
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Malignant tumors of the biliary system are characterized by a high degree of malignancy and strong invasiveness, and they are usually diagnosed at late stages with poor prognosis. This study aimed to comprehensively evaluate the safety and effectiveness of various chemotherapy schemes for the treatment of advanced biliary tract cancer in published systematic reviews and meta-analyses (SRoMAs).
26p
vischultz
20-10-2023
5
1
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The prognosis of patients with advanced biliary tract cancer (BTC) who have progressed on gemcit‑abine plus cisplatin is dismal. Trifluridine/tipiracil (FTD/TPI) and irinotecan have proven efficacy in different gastroin‑ testinal malignancies. We therefore hypothesized that this combination might improve the therapeutic outcome in patients with BTC after failure of first-line treatment.
12p
visharma
20-10-2023
3
2
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Biliary tract cancer (BTC) is a relatively rare but highly aggressive malignancy. However, there is currently no satisfactory second-line regimen for patients without specific genetic mutations. Nanoparticle albumin–bound paclitaxel, also known as nab-paclitaxel (Abraxane, Bristol Myers Squibb), has shown activity in patients with BTC.
7p
vioracle
29-09-2023
12
2
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The objective of this study is to evaluate the cost-effectiveness of adding pembrolizumab to the standard first-line therapy of advanced biliary tract cancer (BTC) with gemcitabine and cisplatin from the perspective of the Chinese healthcare system.
9p
vioracle
29-09-2023
6
3
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The present study aims to evaluate the efficacy and safety of apatinib monotherapy or combination therapy for patients with advanced or recurrent biliary tract cancer (BTC). Apatinib monotherapy or combination therapy can improve PFS in patients with advanced or recurrent BTC who progressed after prior systemic therapies, and adverse reactions can be well tolerated.
7p
vianrose2711
27-04-2021
6
2
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The aim of this study was to determine whether early tumor shrinkage (ETS) at 6 weeks after treatment correlates with progression-free survival (PFS) and overall survival (OS) in advanced biliary tract cancer (BTC) patients receiving gemcitabine plus oxaliplatin (GEMOX), with or without erlotinib.
8p
viamsterdam
18-09-2020
18
1
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Gallbladder cancer is a rare malignancy of the biliary tract with a poor prognosis, frequently presenting at an advanced stage. While rare in the United States overall, gallbladder cancer has an elevated incidence in geographically distinct locations of the globe including Chile, North India, Korea, Japan and the state of New Mexico in the United States.
14p
vibaku2711
22-07-2020
9
2
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Several intervention studies have demonstrated that exercise training has beneficial effects among cancer patients. However, older cancer patients are underrepresented in clinical trials, and only few exercise-based studies have focused specifically on older patients with cancer.
11p
vimanila2711
25-06-2020
14
1
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To date, the cornerstone of treatment in patients with advanced or metastatic cholangiocarcinoma (CCA) is systemic chemotherapy based on a combination of gemcitabine and a platinum derivative.
10p
viputrajaya2711
22-06-2020
8
0
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Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there is still no established targeted therapeutic approach available. Non-surgical therapeutic agents are urgently needed, as most patients are non-eligible to surgical resection.
10p
viputrajaya2711
22-06-2020
10
0
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FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic cancer have been treated similarly with gemcitabine alone or combined with a platinum compound.
8p
vikuala271
13-06-2020
8
2
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Biliary tract cancer (BTC) has a high mortality. Primary diagnosis is frequently delayed due to mostly unspecific symptoms, resulting in a high number of advanced cases at the time of diagnosis. Advanced BTCs are in principle chemotherapy sensitive as determined by improved disease control, survival and quality of life (QoL).
7p
vikuala271
13-06-2020
11
1
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Chemotherapy with gemcitabine and cisplatin has been the standard of care in first-line chemotherapy for advanced biliary tract cancer (BTC) since the trial ABC-02 was published in 2010. We aimed to investigate the prognostic and predictive factors of this regimen in a cohort of Taiwanese patients with advanced BTC.
12p
viorochimaru2711
30-05-2020
9
0
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The field of general surgery has changed dramatically over the last ten years with the acceptance of laparoscopy as an extension of the scalpel. Once ridiculed by most academic centers, laparoscopy has revolutionized the management of biliary tract disease and has led to a critical reassessment of how patients with other general surgical problems are managed. The rapid advancement and acceptance of laparoscopy as a part of general surgery is apparent today since most academic centers have laparoscopic sections and many offer laparoscopic fellowships....
257p
tom_123
15-11-2012
60
7
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