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Advanced thyroid carcinoma
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Papillary and follicular thyroid carcinomas can be treated surgically and with radioiodine therapy, whereas therapeutic options for advanced stage IV medullary and for anaplastic tumours are limited. Recently, somatostatin receptors (SSTs) and the chemokine receptor CXCR4 have been evaluated for the treatment of thyroid carcinomas, however, with contradictory results.
17p
vikolindagrabar
27-07-2022
5
1
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Impact of lenvatinib on renal function: long-term analysis of differentiated thyroid cancer patients
Because lenvatinib is well known to induce proteinuria by blocking the vascular endothelial growth factor (VEGF) pathway, renal function is a concern with long-term administration of lenvatinib. The long-term effects of lenvatinib on renal function in patients with advanced differentiated thyroid carcinoma (DTC) were analyzed.
11p
vimahuateng
26-11-2021
9
1
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Thyroid carcinomas are known to harbor oncogenic driver mutations and advances in sequencing technology now allow the detection of these in fine needle aspiration biopsies (FNA). Recent work by The Cancer Genome Atlas (TCGA) Research Network has expanded the number of genetic alterations detected in papillary thyroid carcinomas (PTC).
10p
vioklahoma2711
19-11-2020
9
1
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Patients with advanced endocrine cancers, such as adrenocortical carcinoma and medullary thyroid carcinoma, have few well-validated therapeutic options. Pre-clinical studies have suggested potential activity of imatinib in these tumors. We therefore sought to establish a safe, novel treatment regimen combining imatinib with cytotoxic chemotherapy for future study in endocrine cancers.
6p
vilisa271
22-09-2020
18
1
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The gain-of-function mutation of the RET proto-oncogene, which encodes a receptor tyrosine kinase, is strongly associated with the development of several medullary thyroid carcinomas (MTCs). Thus, the RET protein has been explored as an excellent target for progressive and advanced MTC.
13p
viamsterdam
18-09-2020
19
1
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Advanced stage operable cancers of larynx are treated with total laryngectomy including thyroid resection in most of the cases, which may expose patient to hypothyroidism and hypoparathyroidism. The requirement of thyroidectomy during Total Laryngectomy is controversial.
6p
vidhaka2711
31-07-2020
17
1
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Intermediate-risk patients are those with any of the following criteria: microscopic tumour invasion into the perithyroidal tissues at initial surgery, cervical lymph node metastases or 131I uptake outside the thyroid bed on the initial post-treatment scan, or tumour with aggressive histology or vascular invasion. Finally, high-risk patients have macroscopic tumour invasion, incomplete tumour resection, distant metastases or elevated thyroglobulin out of proportion to what is seen on the post-treatment scan (Cooper et al., 2009).
398p
wqwqwqwqwq
20-07-2012
107
5
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