Age at onset

Women from Asian and western countries have vastly different ages of onset of breast cancer, with the disease tending to occur at an older age in the West. Through an investigation of the patterns of old-onset breast cancer (OBC) in Korean women, we aimed to identify the characteristics of Korean OBC and evaluate whether these patterns are changing in relation to increasing westernization.

15p vileonardodavinci 23-12-2023 4 3   Download

Cox-regression-based methods have been commonly used for the analyses of survival outcomes, such as age-at-disease-onset. These methods generally assume the hazard functions are proportional among various risk groups. However, such an assumption may not be valid in genetic association studies, especially when complex interactions are involved. In addition, genetic association studies commonly adopt case-control designs.

11p vinarcissa 21-03-2023 5 1   Download

Cerebellar cortical degeneration (CCD) is an increasingly recognised neurodegenerative disease process affecting many dog breeds. Typical presentation consists of a progressive cerebellar ataxia, with a variable age at onset and rate of progression between different breeds.

8p vinarcissa 21-03-2023 1 1   Download

Clinical management of women carrying a germline pathogenic variant (PV) in the BRCA1/2 genes demands for accurate age-dependent estimators of breast cancer (BC) risks, which were found to be affected by a variety of intrinsic and extrinsic factors.

9p visusanwojcicki 28-06-2022 10 3   Download

Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, and has largely been explored by examining the contribution of genotype-by-sex interactions to variation in gene expression.

10p vialfrednobel 29-01-2022 3 0   Download

To reduce costs of rearing replacement heifers, researchers have focused on decreasing age at breeding and first calving. To increase returns upon initiation of lactation the focus has been on increasing mammary development prior to onset of first lactation.

23p viseulgi2711 31-08-2021 37 0   Download

Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population. Current Assessment of Spondyloarthritis International Society (ASAS) classification criteria of AxSpA rely either on sacroiliitis on imaging plus one SpA feature or positive HLAB27 antigen plus two SpA features, in a patient with chronic low back pain and age at onset of less than 45 years.

5p vitennessee2711 02-02-2021 9 2   Download

An early age at Breast Cancer (BC) onset may be a hallmark of inherited predisposition, but BRCA1/2 mutations are only found in a minority of younger BC patients. Among the others, a fraction may carry mutations in rarer BC genes, such as TP53, STK11, CDH1 and PTEN.

6p virose2711 25-09-2020 11 1   Download

To date, the contribution of BRCA1/2 mutations in Moroccan early onset breast cancer patients remains unknown. Here we assess these genetic alterations for the first time in a cohort from North of Morocco. Methods: Thirty-three patients diagnosed with breast cancer at the age of ≤40 years were recruited irrespective of breast and/or ovarian cancer family history.

8p viamsterdam 18-09-2020 9 1   Download

The Centers for Disease Control and Prevention (CDC) defines CAUTI for those patients who have an indwelling catheter in place for 48 h or more and symptoms such as fever or chills, new onset of burning pain, urgency or frequency if not catheterized at that point of time, change in urine character, flank or suprapubic pain or tenderness or change or decrease in mental or functional status in patients. CAUTI is usually presence of at least 10³ colony-forming units (cfu)/mL of 1 or 2 micro-organisms by urine culture.

8p kethamoi6 29-06-2020 16 2   Download

The aim of the present research was to evaluate the potential of blood progesterone (P4) analysis for determination of puberty onset in Bulgarian Murrah buffalo heifers. The experiment was conducted with 13 clinically healthy buffalo heifers from the Bulgarian Murrah breed, at 9 to 20 months of age. Blood samples were collected from all animals and progesterone concentrations were assayed through a commercial ELISA. The time course of blood progesterone was monitored in ascending age order and the correlation between both parameters was evaluated.

7p nguaconbaynhay6 23-06-2020 7 1   Download

The epidemic outbreak of Acute Encephalitis Syndrome (AES) was continuing specially from 2014 onwards and taking toll of pediatric age group distributed in different blocks of Gaya district of Bihar, India. In an extensive survey during outbreak (2016), a case of high fever history was diagnosed having Chandipura virus out of 24 acute fever cases admitted at Anugrah Narayan Memorial Magadh Medical College and Hospital (ANMMMCH) Gaya. Off which nine cases were from Gaya district. The age group of affected cases was 1-15 years. Male were affected more than females (M:F::55.5:44.4).

6p nguaconbaynhay6 23-06-2020 14 0   Download

The present study is undertaken to observe different stages of embryonic development of an Indian major carp, Labeo rohita of two different age groups (+2 and +3), kept under culture and hatchery conditions. The studies of embryonic and larval development provide the essential information regarding the early life history of the target species kept under experimentation. The main aim of this study is to provide information about the comparison of embryonic development of the same species with two different brooder age groups.

11p nguaconbaynhay6 23-06-2020 5 0   Download

Metachronous cancer in patients with head and neck cancer (HNC) is common and is associated with a poor prognosis. We aimed to evaluate the incidence of metachronous cancer at different sites according to age at diagnosis of index HNC.

6p viputrajaya2711 22-06-2020 9 0   Download

Heterozygous germline TP53 gene mutations result in Li-Fraumeni Syndrome (LFS). Breast cancer (BC) is the most frequent tumor in young women with LFS. An important issue related to BC in the Mexican population is the average age at diagnosis, which is approximately 11 years younger than that of patients in the United States (U.S.) and Europe.

10p viputrajaya2711 22-06-2020 8 0   Download

Gastric cancer (GC) is a leading cause of cancer death, occurs predominantly in older age, with increasing incidence in young patients. The Cancer Genome Atlas indicates four subtypes for GC among which Epstein-Barr virus (EBV) subtype is estimated at 8.7%.

7p vikuala271 13-06-2020 6 0   Download

Inherited pathogenic variants in BRCA1 and BRCA2 are the most common causes of hereditary breast and ovarian cancer (HBOC). The risk of developing breast cancer by age 80 in women carrying a BRCA1 pathogenic variant is 72%.

12p vikuala271 13-06-2020 7 0   Download

Invasive urothelial carcinoma (iUC) is highly similar between dogs and humans in terms of pathologic presentation, molecular subtypes, response to treatment and age at onset. Thus, the dog is an established and relevant model for testing and development of targeted drugs benefiting both canine and human patients.

12p vijakarta2711 09-06-2020 9 0   Download

The study was conducted to compare the production performance of Gramariya, Vanaraja, Haringhata Black and Rhode Island Red chickens in intensive condition. The study was undertaken in Murshidabad Krishi Vigyan Kendra of West Bengal state with respect to live body weight in different age, age at sexual maturity, average weight at first egg, average egg production up to 72 weeks of age and average egg weight at 40 weeks. The average body weight at onset of laying of Vanaraja birds was 1747.8 g which was highest than other breeds.

5p chauchaungayxua5 08-05-2020 13 0   Download

Hirschsprung’s disease (HSCR) is a congenital defect caused by impaired development of the enteric nervous system. Inflammatory bowel disease has an increased prevalence in patients with HSCR. We describe the clinical course of a patient with long-segment HSCR who, at the age of 12 months, developed diffuse intestinal inflammation most clinically consistent with very early onset inflammatory bowel disease.

3p covid19 11-05-2020 8 1   Download