Allelic diversity
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Although mosaic variation has been known to cause disease for decades, high-throughput sequencing technologies with the analytical sensitivity to consistently detect variants at reduced allelic fractions have only recently emerged as routine clinical diagnostic tests. To date, few systematic analyses of mosaic variants detected by diagnostic exome sequencing for diverse clinical indications have been performed.
11p vibransone 28-03-2024 2 2 Download
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High sequence identity between segmental duplications (SDs) can facilitate copy number variants (CNVs) via non-allelic homologous recombination (NAHR). These CNVs are one of the fundamental causes of genomic disorders such as the 3q29 deletion syndrome (del3q29S).
17p vicwell 29-02-2024 2 1 Download
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Assessment of genetic diversity of Vigna unguiculata (L.) Walp (cowpea) accessions using informative molecular markers is imperative for their genetic improvement and conservation. The reproducible bands were scored for analyses of dendrograms, principal component analysis, genetic diversity, allele frequency, polymorphic information content, and population structure.
13p vinarcissa 21-03-2023 4 1 Download
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Genetic diversity provides the capacity for plants to meet changing environments. It is fundamentally important in crop improvement. Fifty-nine local maize lines developed at INERA and 41 exotic (temperate and tropical) inbred lines were characterized using 1057 SNP markers to (1) analyse the genetic diversity in a diverse set of maize inbred lines; (2) determine the level of genetic diversity in INERA inbred lines and patterns of relationships of these inbred lines developed from two sources; and (3) examine the genetic differences between local and exotic germplasms.
14p vinarcissa 21-03-2023 6 1 Download
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Root is the prime organ that sucks water and nutrients from deep layer of soil. Wild barley diversity exhibits remarkable variation in root system architecture that seems crucial in its adaptation to abiotic stresses like drought. In the present study, we performed quantitative trait locus (QTL) mapping of root and related shoot traits under control and drought conditions using a population of wild barley introgression lines (ILs).
12p vinarcissa 21-03-2023 4 1 Download
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Sesame is an important and ancient oil crop in tropical and subtropical areas. China is one of the most important sesame producing countries with many germplasm accessions and excellent cultivars.
15p vinarcissa 21-03-2023 4 1 Download
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Indian agriculture is an economic symbiosis of crop and livestock production with cattle as the foundation. Sadly, the population of indigenous cattle (Bos indicus) is declining (8.94 % in last decade) and needs immediate scientific management. Genetic characterization is the first step in the development of proper management strategies for preserving genetic diversity and preventing undesirable loss of alleles.
12p vinarcissa 21-03-2023 4 1 Download
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Improving the gelatinization temperature (GT), gel consistency (GC) and amylose content (AC) for parental grain eating and cooking qualities (ECQs) are key factors for enhancing average grain ECQs for hybrid japonica rice.
18p vihagrid 30-01-2023 8 3 Download
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The Wright’s fixation index (Fst) and the principal component analysis (PCA) are widely used methods in animal genetics studies. In paper we compared the power of these methods, their complementing each other and which of them is the most powerful.
15p vihagrid 30-01-2023 6 3 Download
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Multi-parent populations (MPPs) are important resources for studying plant genetic architecture and detecting quantitative trait loci (QTLs). In MPPs, the QTL effects can show various levels of allelic diversity, which can be an important factor influencing the detection of QTLs.
12p vihagrid 30-01-2023 11 3 Download
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The study aims to evaluate the genomic diversity of some local melientha suavis Pierre SSR technique. By using 10 primer pairs to analyze 20 melientha suavis Pierre lines shows that the number of Alleles were from 2 to 4 alleles and the polymorphic information contents ranged from 0.05 to 0.15. Forty-one alleles were identified with avarage of 0.15 alleles.
8p viharry 15-12-2022 19 3 Download
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Despite the tremendous growth of the DNA sequencing data in the last decade, our understanding of the human genome is still in its infancy. To understand the implications of genetic variants in the light of population genetics and molecular evolution.
16p vielonmusk 30-01-2022 13 0 Download
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A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines. RNA editing has emerged as a widespread mechanism for generating transcriptome diversity. However, there remain significant knowledge gaps about the variation and function of RNA editing.
15p vialfrednobel 29-01-2022 11 0 Download
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In contrast to positive selection, which reduces genetic variation by fixing beneficial alleles, balancing selection maintains genetic variation within a population or species and plays crucial roles in adaptation in diverse organisms. However, which genes, genome-wide, are under balancing selection and the extent to which these genes are involved in adaptation are largely unknown.
15p vialfrednobel 29-01-2022 9 0 Download
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Allele-specific measurements of transcription factor binding from ChIP-seq data are key to dissecting the allelic effects of non-coding variants and their contribution to phenotypic diversity. However, most methods of detecting an allelic imbalance assume diploid genomes.
17p vialfrednobel 29-01-2022 10 0 Download
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The current bovine genomic reference sequence was assembled from a Hereford cow. The resulting linear assembly lacks diversity because it does not contain allelic variation, a drawback of linear references that causes reference allele bias.
27p viarchimedes 26-01-2022 6 0 Download
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Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expanded, studying lncRNA function has been a challenge due to their diverse biological roles and because lncRNA loci can contain multiple molecular modes that may exert function.
35p viarchimedes 26-01-2022 9 0 Download
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The genus Adonis L. is a member of Ranunculaceae and consists of perennial and annual herbaceous plants included in the tribe Adonideae under the subfamily Ranunculoideae. Botanically, Ranunculaceae comprises vital medicinal plants. Molecular markers are one of the most effective tools for exploring genetic variation that can enhance breeding efficiency. To identify the genetic diversity of 62 Adonis ecotypes collected from different regions in Turkey, the interprimer binding site (iPBS) retrotransposon system was used.
12p tudichquannguyet 29-11-2021 11 1 Download
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Medicago ciliaris (L.) Krock and Medicago intertexta (L.) Mill are most often found in saline regions and are considered as potential resources for genes related to salinity resistance. To explore the genetic diversity of these two species by mean of nrSSR (simplesequence repeats) markers, 11 accessions originated from different regions in north of Africa and Middle East were chosen. Ten among 14 markers turned out to be polymorphic and gave 72 alleles. Eight markers were very informative with PIC values > 0.5, and three of them were found to be nonneutral.
12p tudichquannguyet 29-11-2021 7 1 Download
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Orobanche cumana is a parasitic plant that can lead to advanced losses in yield of agricultural lands cultivating sunflower, depending on the sunflower varieties and the level of contamination. In our study, genetic diversity of six O. cumana populations from the Thrace region of Turkey was determined with the help of eight SSR (microsatellite) loci. All SSR loci were polymorphic. A total of 23 alleles were determined for the analyzed 120 samples. Allele number of each SSR locus ranged from two to six. Mean number of alleles (Na = 2.271), effective allele number (Ne = 1.
10p tudichquannguyet 29-11-2021 9 1 Download