Animal model

A large number of studies have demonstrated the wound-healing effects of LLLT in vitro, in animal models, and in clinical practice. However, there are also differences in the study results, which are dose and wavelength dependent of LLLT. Objective: Evaluation of the wound healing process in experimental animals treated with low- level laser therapy in clinical and histopathology.

8p viharuno 03-01-2025 5 2   Download

The purpose of this study was to create an animal model of a mandibular alveolar bone defect without compromising the animal’s well-being. Materials and methods: A total of 24 New Zealand white rabbits underwent surgery to create mandibular alveolar bone defects.

10p viharuno 03-01-2025 3 2   Download

In diabetic patients, the body does not produce enough insulin or not properly respond to insulin. Insulin is a hormone produced by -cells of the pancreas. It stimulates the cells to absorb the glucose from the blood and its hyposecretion may leads to the over accumulation of glucose in the blood and often leading to various complications.

82p spiritedaway36 26-11-2021 20 3   Download

The present research reviewed previously published studies with the objective to enhance the understandings of the effects of different drugs on bone healing. There is clear evidence that antibiotics, corticosteroids, nonsteroidal inflammatory drugs, and chemotherapeutic drugs all affect bone healing.

11p chauchaungayxua12 09-07-2021 12 2   Download

Research objectives: Use the blended learning model in teaching to improve teaching efficiency and improve the online self-study capacity of human and animal physiology for biology pedagogy students.

27p thebadguys 08-06-2021 24 4   Download

This research with two aims: Establishing an animal model of autism using Swiss white mice by prenatal exposure to sodium valproate. Evaluating the effects of enriched environment on behaviors in modelled white mice

27p petsematary 02-06-2021 17 4   Download

This article is devoted to the study of the attitude to organic food of residents of Southern Russia in connection with the development of a regional model of organic animal husbandry.

9p guineverehuynh 18-06-2020 11 2   Download

Hepcidin (H25) is a hormone peptide synthesized by the liver that binds to ferroportin and blocks iron export. In this study, H25 was inhibited by administration of single and multiple doses of an anti-H25 monoclonal antibody Ab 12B9m in cynomolgus monkeys. The objective of this analysis was to develop a pharmacodynamic model describing the role of H25 in regulating iron homeostasis and the impact of hepcidin inhibition by Ab 12B9m. Total serum H25 and Ab 12B9m were determined in each animal. Corresponding measurements of serum iron and hemoglobin (Hb) were obtained.

15p caothientrangnguyen 09-05-2020 13 1   Download

Quantifying the multiple processes which control and modulate the extent of oral bioavailability for drug candidates is critical to accurate projection of human pharmacokinetics (PK). Understanding how gut wall metabolism and hepatic elimination factor into first-pass clearance of drugs has improved enormously. Typically, the cytochrome P450s, uridine 5′- diphosphate-glucuronosyltransferases and sulfotransferases, are the main enzyme classes responsible for drug metabolism. Knowledge of the isoforms functionally expressed within organs of first-pass clearance, their anatomical topology (e.

16p caothientrangnguyen 09-05-2020 20 1   Download

Most (78%) mitochondrial genomes in the studied mutant strain of Drosophila subobscura have undergone a large-scale deletion (5 kb) in the coding region. This mutation is stable, and is transmitted intact to the offspring. This animal model of major rearrangements of mitochondrial genomes can be used to analyse the involvement of the nuclear genome in the production and maintenance of these rearrangements.

8p research12 01-06-2013 52 6   Download

ProLiV - Animated Process-modeler of Complex (Computational) Linguistic Methods and Theories - is a fully modular, flexible, XML-based stand-alone Java application, used for computer-assisted learning in Natural Language Processing (NLP) or Computational Linguistics (CL).

4p hongphan_1 15-04-2013 64 4   Download

Protein aggregation is central to most neurodegenerative diseases, as shown by familial case studies and by animal models. A modified ‘amyloid cas-cade’ hypothesis for Alzheimer’s disease states that prefibrillar oligomers, also called amyloid-b-derived diffusible ligands or globular oligomers, are the responsible toxic agent. It has been proposed that these oligomeric spe-cies, as shown for amyloid-b, b2 -microglobulin or prion fragments, exert toxicity by forming pores in membranes, initiating a cascade of detrimental events for the cell. ...

10p awards 06-04-2013 42 3   Download

The herpes simplex virus thymidine kinase⁄ganciclovir (HSV-tk⁄GCV) sys-tem that selectively depletes cells expressing HSV-tk upon treatment with GCV has provided a valuable tool for developing a new animal model expressing the desired tissue damage. In this paper, an HSV-tk vector with an albumin promoter⁄enhancer was constructed. Based on the favourable killing effect on Hep-G2 cells by the recombinant construct, the HSV-tk transgenic mouse strains were developed.

9p awards 06-04-2013 54 3   Download

Propionate is used to protect bread and animal feed from moulds. The mode of action of this short-chain fatty acid was studied usingAspergillus nidulansas a model organism. The filamentous fungus is able to grow slowly on propio-nate, which is oxidized to acetyl-CoA via propionyl-CoA, methylcitrate and pyruvate. Propionate inhibits growth of A. nidulanson glucose but not on acetate; the latter was shown to inhibit propionate oxidation.

15p awards 05-04-2013 46 3   Download

Some 40-odd genes in mammals encode phosphotyrosine-specific, ‘classical’ protein tyrosine phosphatases. The generation of animal model systems and the study of various human disease states have begun to elucidate the important and diverse roles of protein tyrosine phosphatases in cellular sig-nalling pathways, development and disease.

15p media19 05-03-2013 33 2   Download

Different inhibitors of the Ca 2+ ⁄calmodulin-stimulated phosphodiester-ase 1 family have been described and used for the examination of phospho-diesterase 1 in cellular, organ or animal models. However, the inhibitors described differ in potency and selectivity for the different phosphodiester-ase family enzymes, and in part exhibit additional pharmacodynamic actions.

13p media19 04-03-2013 20 1   Download

Hypoxia and hypoxia-related genes are important factors in articular chon-drocytes during cartilage homeostasis and osteoarthritis. We have investi-gated the various apoptotic factors that show significance in synovial fluid obtained from normal and experimental osteoarthritic animal models and have evaluated the effect of hypoxia on articular chondrocyte apoptosis induced by these apoptotic factors.

11p vinaphone15 28-02-2013 37 2   Download

In an attempt to identify potential therapeutic targets for the correction of muscle wasting, the gene expression of several pivotal proteins involved in protein metabolism was investigated in experimental atrophy induced by transient or definitive denervation, as well as in four animal models of muscular dystrophies (deficient for calpain 3, dysferlin,a-sarcoglycan and dystrophin, respectively).

16p vinaphone15 27-02-2013 44 2   Download

Activation of peroxisome proliferator-activated receptor (PPAR)-c sup-presses proliferation of rat pulmonary artery smooth muscle cells (PASMCs), and therefore ameliorates the development of pulmonary hypertension in animal models. However, the molecular mechanisms under-lying this effect remain largely unknown.

8p mobifone23 18-01-2013 40 2   Download

A decade ago, a disintegrin and metalloproteinase 10 (ADAM10) was iden-tified as ana-secretase and as a key proteinase in the processing of the amy-loid precursor protein. Accordingly, the important role that it plays in Alzheimer’s disease was manifested. Animal models with an overexpression of ADAM10 revealed a beneficial profile of the metalloproteinase with respect to learning and memory, plaque load and synaptogenesis.

12p mobifone23 18-01-2013 30 3   Download