Anti-neoplastic propertie
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5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent.
10p vidarwin 23-02-2022 15 1 Download
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Schiff base derivatives with anthracene- and pyrene-based units, A1-A6 and P1-P6 were synthesized (89%–99% yields). Schiff base derivatives were designed to possess an heterocyclic moiety on one side to enhance the coordination ability towards metals. To investigate the biological assay of the newly synthesized compounds, their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, metal chelating, reducing power, antibacterial and DNA binding activities were tested. A6 (63.1%) showed the maximum free radical scavenging activity among all.
16p tudichquannguyet 29-11-2021 7 2 Download
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Activation of cyclooxygenase (COX)/prostaglandin and nuclear factor κB (NFκB) pathways can promote breast tumor initiation, growth, and progression to drug resistance and metastasis. Thus, anti-inflammatory drugs have been widely explored as chemopreventive and antineoplastic agents.
12p vimoscow2711 29-08-2020 12 0 Download
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Proanthocyanidin (PAC) is a promising compound that has displayed its potent antineoplastic properties with a specific intrinsic pathway. This precise us to explore the phyto-preventive effect of PAC against colon cancer (HT-29).
14p vijiraiya2711 27-05-2020 19 1 Download
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Cardiomyocyte under hypoxia cause cell death or damage is associated with heart failure. Gap junction, such as connexin 43 play a role in regulation of heart function under hypoxia. Caffeic acid phenethyl ester (CAPE) has been reported as an active component of propolis, has antioxidative, anti-inflammatory antiproliferative and antineoplastic biological properties.
5p viwashington2711 04-12-2019 12 1 Download
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A subset M E(G) of the edge set E(G) of a graph G is called a matching provided that no two edges in M have a vertex in common. A perfect matching M is a matching with the property that each vertex of G is incident with an edge in M. For k a positive integer, a graph G is k-extendable provided that G has a matching of size k and every matching in G of size at most k can be extended to a perfect matching in G.
15p thulanh6 14-09-2011 56 4 Download