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Bidirectional promoters
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MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor
The Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor.
13p
visharma
20-10-2023
8
2
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In contrast to unidirectional promoters wherein antisense transcription results in short transcripts which are rapidly degraded, bidirectional promoters produce mature transcripts in both sense and antisense orientation. To understand the molecular mechanism of how productive bidirectional transcription is regulated, we focused on delineating the chromatin signature of bidirectional promoters.
20p
vibeauty
23-10-2021
5
1
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Heart development is a relatively fragile process in which many transcription factor genes show dosesensitive characteristics such as haploinsufficiency and lower penetrance. Despite efforts to unravel the genetic mechanism for overcoming the fragility under normal conditions, our understanding still remains in its infancy.
12p
viseulgi2711
31-08-2021
4
1
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Expression of caveolin-1 (Cav-1) is frequently altered in many human cancers and both tumor suppression and promotion functions of Cav-1 have been suggested based on its expression status.
14p
vimanama2711
30-07-2020
10
2
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In the presence of sufficient iron, the Escherichia coli protein Fur (Ferric Uptake Regulator) represses genes controlled by the Fur box, a consensus sequence near or within promoters of target genes. De-repression of Fur-controlled genes occurs upon iron deprivation.
11p
vihamax2711
21-04-2020
12
1
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