Bioactive heterocyclic compounds

Ebook "Total synthesis of bioactive natural products by palladium-catalyzed domino cyclization of allenes and related compounds" total synthesis of the bioactive natural products, pachastrissamine, lysergic acid, lysergol and isolysergol, by palladium-catalyzed domino cyclization of allenes and related compounds is investigated. Gives an insight to the development of efficient synthetic approaches for biologically active compounds.

115p nhanphanguyet 28-01-2024 5 2   Download

The antimicrobial activity of the products was evaluated and the results revealed that compounds 8f and 15f showed strong activity against gram-positive bacteria while compound 15d showed the highest activity against gramnegative bacteria. Moreover, compounds 15b, 8d, 8e, 8c, 8l, and 8j exhibited significant antifungal activity. In addition, the antitumoral activity of the synthesized products against different cancer cell lines was determined and the results revealed that compound 12c was the most active against MCF-7, HepG-2, HCT-116, and HeLa with IC50 values of 0.51, 0.72, 0.95, and 0.

22p langthannam 29-12-2021 14 0   Download

The aim of this study is to obtain new unsaturated piperazine compounds by the reactions of piperazine (1a) and piperazine derivatives (1b–1d) with acylation reactive groups (2a–2j). Methacryloyl piperazine (1b) was synthesized from the reaction of methacrylic anhydride with piperazine (1a).

55p tudichquannguyet 29-11-2021 8 1   Download

Benzimidazole is a heterocyclic moiety whose derivatives are present in many of the bioactive compounds and posses diverse biological and clinical applications. Benzimidazole agents are the vital pharmacophore and privileged sub-structures in chemistry of medicine.

27p vijiraiya2711 27-05-2020 10 1   Download

Chalcones are intent in the daily diet as a favorable chemotherapeutic compound; on the other hand thiophene moiety is present in a large number of bioactive molecules having diverse biological effciency.

8p vijiraiya2711 27-05-2020 9 1   Download

Coumarin and its derivatives are heterocyclic compounds which gives toxic effects when it is used in higher quantity. In lower amount it is also toxic to marine plants and animals like fish, phytoplanktons, zooplanktons etc. According to various data it is confirmed that coumarin can be harmful for human being also though it is used in cosmetics, pharmaceutical industries and various medicines like anti-cancer and anti-coagulant.

5p quenchua2 15-12-2019 7 0   Download

Coscinium fenestratum (Gaertn.) Colebr, commonly called as daruharidra which belongs to Menispermaceae family is rich with bioactive secondary metabolites that might signify valuable leads in the production of new pharmaceutical agents. The metabolite accumulation in the plants varies with the environmental factors, expression level of enzymes, climatic conditions etc. To evaluate the difference of metabolite in the cultivated vine, the sample was analysed by High performance Liquid Chromatography-Mass Spectrometry (HPLC-MS).

8p nguaconbaynhay1 04-12-2019 19 1   Download