Bioinformatic studies

Numerous studies have indicated that cancer-associated fibroblasts (CAFs) play a crucial role in the progression of colorectal cancer (CRC). However, there are still many unknowns regarding the exact role of CAF subtypes in CRC.

20p vishanshan 27-06-2024 1 1   Download

This study aimed to systematically analyze the effect of a serine/threonine kinase (STK11) mutation (STK11mut) on therapeutic efficacy and prognosis in patients with non-small cell lung cancer (NSCLC).

12p vishanshan 27-06-2024 2 1   Download

Proprotein convertase subtilisin/kexin type 9 (PCSK9), the last member of the proprotein convertase family, functions as a classic regulator of low-density lipoprotein (LDL) by interacting with low-density lipoprotein receptor (LDLR). Recent studies have shown that PCSK9 can affect the occurrence and development of tumors and can be used as a novel therapeutic target. However, a comprehensive pan-cancer analysis of PCSK9 has yet to be conducted.

13p vishanshan 27-06-2024 1 1   Download

Tumor immune infiltration leads to poor prognosis of gastric cancer patients and seriously affects the life quality of gastric cancer patients. This study was based on bioinformatics to screen prognostic biomarkers in patients with high degree of immune invasion of gastric cancer.

14p vikoch 27-06-2024 2 1   Download

This study aims to identify functionally relevant lncRNAs impacting OS proliferation and lipid metabolism and seeks to shed light on the upstream regulatory mechanisms governing lipogenic enzyme activity. Based on comprehensive bioinformatic analysis and the establishment of a risk model, we identified seven lncRNAs signifcantly associated with clinical characteristics and lipid metabolism-related genes in patients with OS.

15p vikoch 27-06-2024 1 1   Download

Ebook "A systems biology approach to study metabolic syndrome" is to provide the target audience, specifically students of Medicine, Biology, Systems Biology and Bioinformatics, as well as experienced researchers in research fields relevant to metabolic syndrome (MetS) with an overview of the challenges and opportunities in systems biology and how it can be used to tackle MetS.

393p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "Immunoformatics: Bioinformatic strategies for better understanding of immune function" is the first to feature thorough coverage of this new field. Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data.

271p tracanhphuonghoa1007 22-04-2024 2 1   Download

Single-cell RNA sequencing (scRNA-Seq) is an increasingly popular platform to study heterogeneity at the single-cell level. Computational methods to process scRNA-Seq data are not very accessible to bench scientists as they require a significant amount of bioinformatic skills.

12p vioraclene 31-03-2024 3 2   Download

Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classic pharmacokinetic genes is rather well understood, the role of genetic variation in drug targets is typically less studied.

15p vioraclene 31-03-2024 5 1   Download

Twin studies are powerful models to elucidate epigenetic modifications resulting from gene–environment interactions. Yet, commonly a limited number of clinical twin samples are available, leading to an underpowered situation afflicted with false positives and hampered by low sensitivity.

15p vioraclene 31-03-2024 6 2   Download

This study aims to identify microbiomic differences in paired tumor and non-tumor tissue samples in a large group of 121 patients with head and neck squamous cell carcinomas and correlate these differences with clinical-pathologic features.

10p vioraclene 31-03-2024 5 2   Download

Whole genome sequencing is increasingly being used for the diagnosis of patients with rare diseases. However, the diagnostic yields of many studies, particularly those conducted in a healthcare setting, are often disap‑ pointingly low, at 25–30%. This is in part because although entire genomes are sequenced, analysis is often confined to in silico gene panels or coding regions of the genome.

25p vicwell 29-02-2024 3 1   Download

Ebook "Bioinformatics: Applications in life and environmental sciences" is aiming to provide information on bioinformatics at various levels. The chapters included in this book cover introductory to advanced aspects, including applications of various documented research work and specific case studies related to bioinformatics.

254p tachieuhoa 28-01-2024 5 2   Download

Ebook "Genomics of tree crops" cover a wide area of concepts and methods; written by a panel of renowned experts in the field; an indispensable guide for scientists, advanced students, and teachers studying tree genomics. Genomics of Tree Crops is an earnest attempt towards compiling genomics of tree crops.

377p tachieuhoa 28-01-2024 7 2   Download

Ebook "AMPK: Methods and protocols" explores the latest methods used to study AMPK by computational, biochemical, biophysical, cellular, and ex vivo and in vivo approaches. The chapters in this book cover specific topics, such as methods to measure change in cellular energy metabolism and analyze metabolic pathways regulated by AMPK; bioinformatics tools to identify AMPK targets; knockdown of AMPK by CRISPR-Cas9;...

617p lucchinguyen 28-12-2023 4 2   Download

Ebook "Bacterial protein secretion systems: Methods and protocols" details protocols that cover the broad arsenal of techniques used to study a secretion system from A to Z. Chapters focus on identifying and localizing the different subunits, defining interactions within subunits, monitoring conformational changes, purifying and imaging of large complexes, defining the assembly pathway by fluorescence microscopy and the role of energy during assembly and/or secretion, identifying secreted effectors as well as reporters to follow effector transport.

521p lucchinguyen 28-12-2023 4 2   Download

Ebook "mRNA decay: Methods and protocols" explores the latest methods that can be used to probe mRNA decay pathways and identify mRNA-binding protein targets as well as miRNA targets. Subjects include metabolic labelling and RNAseq methods for determining RNA decay rates, approaches for discovering RNA-binding protein targets, bioinformatics, miRNA targets and novel components of the miRNA-directed decay pathway, and recently developed approaches for studying nonsense-mediated mRNA decay, among other areas.

231p lucchinguyen 28-12-2023 7 2   Download

Part 1 book "Farm animal proteomics 2013" includes content: Mining deeper into the proteome - pros and cons of pre-fractionation and depletion; detection and annotation of common posttranslational modifications in mass spectrometry data, applied bioinformatics in the structural, postgenomic era, PTMomics – a potpourri of experimental approaches; gel-free quantitative proteomics approaches, current status; new proteomics strategies applied to clinical studies,... and other contents.

168p muasambanhan02 18-12-2023 0 0   Download

Bladder cancer (BLCA) is the ninth most common cancer globally, as well as the fourth most common cancer in men, with an incidence of 7%. However, few effective prognostic biomarkers or models of BLCA are available at present.

19p vileonardodavinci 23-12-2023 5 2   Download

Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response.

16p vileonardodavinci 23-12-2023 3 2   Download