Biological age estimation

DNA methylation changes with age. Chronological age predictors built from DNA methylation are termed ‘epigenetic clocks’. The deviation of predicted age from the actual age (‘age acceleration residual’, AAR) has been reported to be associated with death. However, it is currently unclear how a better prediction of chronological age affects such association.

11p vibransone 28-03-2024 6 2   Download

Epigenetic clocks can track both chronological age (cAge) and biological age (bAge). The latter is typically defined by physiological biomarkers and risk of adverse health outcomes, including all-cause mortality. As cohort sample sizes increase, estimates of cAge and bAge become more precise. Here, we aim to develop accurate epigenetic predictors of cAge and bAge, whilst improving our understanding of their epigenomic architecture.

15p vicwell 29-02-2024 7 1   Download

Part 2 book "Introduction to horse biology" includes content: The respiratory system, the nervous system, the endocrine system, reproduction, disease causing organisms, genetics and heredity, teeth and estimating age.

110p oursky08 04-11-2023 7 3   Download

Gestational age is often used as a proxy for developmental maturity by clinicians and researchers alike. DNA methylation has previously been shown to be associated with age and has been used to accurately estimate chronological age in children and adults.

11p viaristotle 29-01-2022 8 0   Download

The health index measures a person’s overall health status which provides useful information for people to manage their health, so developing a precise and relevant health index is urgent.

16p guernsey 28-12-2021 14 0   Download

Risk of hospitalized infections under biologics among patients suffering from chronic inflammatory autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriatic arthritis (PSA), or psoriasis was investigated using administrative data. The hospital discharge records database, the medical prescription database, and the database of exemptions from medical charges were linked at the individual patient level.

7p trinhthamhodang1 14-11-2019 16 0   Download

Multiple sclerosis (MS) is not a new disease. Its effects on the brain were described in the 1830s, and it was identified as a distinct clinical entity in the 1860s. In fact, writings from the Middle Ages appear to describe individuals with this condition. MS is the most common neurological disorder of young adults; there are approximately 350,000 people with MS in the United States and an estimated 2 million patients worldwide. Research on the disorder has been energetic over recent decades. In 1996, the U.S. National Institutes of Health (NIH) spent almost $83 million on MS research.

457p haiduong_1 27-02-2013 56 4   Download

All family members need to take time to plan their retirement. To include Social Security in that retirement plan you can go to the Social Security Administration’s website at www.ssa.gov. This site contains graphs, charts and forms to help you determine how much to contribute and when to retire. Retirement age graphs are provided so you can see the difference in the amount of your payments when you retire at the earliest possible date or wait until you are five to eight years older. The site also contains a retirement estimator, benefit calculators and instructions...

58p bi_ve_sau 05-02-2013 46 3   Download

Survival rates vary with the biological characteristics of the tumour and the stage of development at which it is detected. About 50% of patients have early disease at the time of initial diagnosis (stage I, T1, N0 – tumour confined to breast)5 , for which the prognosis is excellent; fewer than 5% of patients have metastatic disease (stage IV) at this point, although the likelihood of an initial diagnosis of advanced breast cancer tends to increase with age.

47p taisaokhongthedung 07-01-2013 53 3   Download

There is a growing body of evidence which demonstrates that following a diet that complies with the Dietary Guidelines may reduce the risk of chronic disease. Recently, it was reported that dietary patterns consistent with recommended dietary guidance were associated with a lower risk of mortality among individuals age 45 years and older in the United States.4 The authors of the study estimated that about 16 percent and 9 percent of mortality from any cause in men and women, respectively, could be eliminated by the adoption of desirable dietary behaviors.

48p ut_hai_can 26-12-2012 74 4   Download

The most commonly used measures of current fertility are the total fertility rate (TFR) and its component age-specific fertility rates (ASFRs). The TFR is an estimate of the average number of births a woman would have at the end of her reproductive years if she bears children at the prevailing age-specific fertility rates throughout her childbearing years (age 15-49). The ASFRs are defined in terms of the number of live births among women in a particular age group divided by the number of woman-years in that age group during the specific period. Figure 4.

33p thankinhphanliet 21-12-2012 39 3   Download

Few members of the general public are fully aware of the extent to which the atomic age affects their everyday lives. For many, bombs and power plants are their only associations with the term. The uses and benefits of radioactive isotopes in medicine, agriculture, industry, and science are widespread, however, allowing us to perform many tasks more accurately, more simply, less expensively, and more quickly than would otherwise be possible. In many cases, biological tracers for example, there is no alternative.

145p echbuon 02-11-2012 71 5   Download

Although substantial economic development and improvement of health services have occurred, Asia is a heterogeneous and resource-constrained continent. Over half of the 50 million people with epilepsy worldwide are estimated to live in Asia (Mac et al., 2007). There are some biological differences in epilepsy between Asia and the West, mainly related to the young average age and smaller physique among Asians. This probably partly explains the smaller doses of antiepileptic drugs found effective in some trials involving Asians (Yang et al., 2007).

340p ti_du_hoang 15-08-2012 74 5   Download