Biological heterogeneity
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Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease, and gene expression profiling has identified several molecular subtypes with distinct biological and clinicopathological characteristics. While MIBC subtyping has primarily been based on messenger RNA (mRNA), long non-coding RNAs (lncRNAs) may provide additional resolution.
13p vibransone 28-03-2024 4 2 Download
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The human plasma proteome is important for many biological processes and targets for diagnostics and therapy. It is therefore of great interest to understand the interplay of genetic and environmental factors to determine the specific protein levels in individuals and to gain a deeper insight of the importance of genetic architecture related to the individual variability of plasma levels of proteins during adult life.
16p vibransone 28-03-2024 5 2 Download
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Left-sided lesions (LSLs) account for an important fraction of severe congenital cardiovascular malformations (CVMs). The genetic contributions to LSLs are complex, and the mutations that cause these malformations span several diverse biological signaling pathways: TGFB, NOTCH, SHH, and more.
10p vioraclene 31-03-2024 8 2 Download
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Advances in cancer biology are increasingly dependent on integration of heterogeneous datasets. Large-scale efforts have systematically mapped many aspects of cancer cell biology; however, it remains challenging for individual scientists to effectively integrate and understand this data.
12p vibransone 28-03-2024 5 2 Download
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Part 2 book "Numerical techniques for chemical and biological engineers using MATLAB - A simple bifurcation approach" includes content: Boundary value problems, heterogeneous and multistage systems, industrial problems.
330p muasambanhan09 16-03-2024 4 2 Download
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Ebook "Protein metabolism and homeostasis in aging (Advances in experimental medicine and biology, Volume 694)" provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data.
268p duongthandue0501 28-02-2024 1 1 Download
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Transcriptional classifcation has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent discrete, mutually exclusive entities or molecular/phenotypic states with potential overlap.
17p vicwell 29-02-2024 4 1 Download
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Recent studies using single-cell transcriptomic analysis have reported several distinct clusters of neo‑ plastic epithelial cells and cancer-associated fibroblasts in the pancreatic cancer tumor microenvironment. However, their molecular characteristics and biological significance have not been clearly elucidated due to intra- and intertumoral heterogeneity.
18p vicwell 29-02-2024 3 1 Download
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Ebook "Endemism in vascular plants (Plant and vegetation, Volume 9)" is the first comprehensive analysis of the macroecology and geobotany of endemic vascular plants with case-studies and analyses from different regions in the world. Endemism is a pre-extinction phenomenon. Endemics are threatened with extinction. Due to international nature conservation policies and due to the perception of the public the concept’s importance is increasing. Endemism can result from different biological and environmental processes.
354p manmanthanhla0201 26-02-2024 2 1 Download
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Ebook "Applications of EPR in radiation research" presented in eight themes: elementary radiation processes (in situ and low temperature radiolysis, quantum solids); solid state radiation chemistry (crystalline, amorphous and heterogeneous systems); biochemistry, biophysics and biology applications (radicals in biomaterials, spin trapping, free-radical-induced DNA damage); materials science (polymeric and electronic materials, materials for treatment of nuclear waste, irradiated food);...
766p nhanphanguyet 28-01-2024 5 2 Download
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Ebook "Aptamers selected by Cell-SELEX for theranostics" as the fundamental tool used to generate aptamer molecules for a wide range of applications in molecular medicine, bioanalysis and chemical biology. Easily integrated into the natural heterogeneous cell matrix, aptamers can be effectively used in theranostics, bioanalysis, environment detection and biomedical studies.
352p nhanphanguyet 28-01-2024 2 2 Download
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Ebook "Principles and methods in landscape ecology: Towards a science of the landscape" is a textbook useful to present the landscape in a multi-vision perspective for undergraduate and graduate students of biology, ecology, geography, forestry, agronomy, landscape architecture and planning. Sociology, economics, history, archaeology, anthropology, ecological psychology are some sciences that can benefit of the holistic vision offered by this textbook.
430p tachieuhoa 28-01-2024 4 2 Download
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Ebook "Cellular heterogeneity: Methods and protocols" is essential for anyone struggling with the cellular heterogeneity field, and it connects this new area with the latest advances in innovative techniques combined with practical advice from international experts. The chapters provide a comprehensive overview of cellular heterogeneity analysis techniques, exploring cytometry, imaging and spectroscopy methods, metabolic and molecular biological methods in tracking, as well as chromatin and cell cycle heterogeneity.
363p lucchinguyen 28-12-2023 8 3 Download
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Ebook "Cancer systems biology: Methods and protocols" comprises protocols describing systems biology methodologies and computational tools, offering a variety of ways to analyze different types of high-throughput cancer data. Chapters give an overview over data types available in large-scale data repositories and state-of-the-art methods used in the field of cancer systems biology.
397p lucchinguyen 28-12-2023 7 2 Download
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Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically over the past decades.
9p vileonardodavinci 23-12-2023 6 4 Download
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Pancreatic cancer (PC) is a highly malignant tumor featured with high intra-tumoral heterogeneity and poor prognosis. Cell-in-cell (CIC) structures have been reported in multiple cancers, and their presence is associated with disease progression. Nonetheless, the prognostic values and biological functions of CIC-related genes in PC remain poorly understood.
24p vialfrednobel 23-12-2023 7 5 Download
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Although the incidence of late-onset colorectal cancer (LOCRC) has decreased, the incidence of earlyonset colorectal cancer (EOCRC) is still rising dramatically. Heterogeneity in the genomic, biological, and clinicopathological characteristics between EOCRC and LOCRC has been revealed.
19p vioracle 29-09-2023 3 2 Download
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It is common that cancer patients have different molecular signatures even though they have similar clinical features, such as histology, due to the heterogeneity of tumors. To overcome this variability, we previously developed a new approach incorporating prior biological knowledge that identifies knowledge-driven genomic interactions associated with outcomes of interest.
11p visteverogers 24-06-2023 5 3 Download
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Unsupervised machine learning approaches hold promise for large-scale clinical data. However, the heterogeneity of clinical data raises new methodological challenges in feature selection, choosing a distance metric that captures biological meaning, and visualization.
9p vighostrider 25-05-2023 3 2 Download
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Advanced understanding of tumor biology has recently revealed the complexity of cancer genetics, intra/inter-tumor heterogeneity, and diverse mechanisms of resistance to cancer treatment. In turn, there has been a growing interest in cancer prevention and minimizing exposure to potential environmental carcinogens that sur‑ round us.
12p vigamora 23-05-2023 8 2 Download