Breast epithelial cells
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In this study, we present the result of co-culture between adipose tissue mesenchymal stem cells (ADMSCs) and breast cancer cells (MCF-7 cell line) and determine the expression levels of transcription factorsinvolved in EMT, including Twist and Snail.
9p vinatis 02-08-2024 0 0 Download
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Breast cancer is a complex disease exhibiting a great degree of heterogeneity due to different molecular subtypes. Notch signaling regulates the differentiation of breast epithelial cells during normal development and plays a crucial role in breast cancer progression through the abnormal expression of the Notch up-and down-stream effectors.
21p vileonardodavinci 23-12-2023 4 2 Download
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CD147, a transmembrane glycoprotein, has been implicated in various cancer-related processes but its role in breast cancer remains poorly understood. Herein, we investigated the expression of CD147 in different breast cancer cell lines and explored its functional roles, including migration, invasion, drug resistance and modulation of key proteins associated with cancer progression.
11p vileonardodavinci 23-12-2023 3 2 Download
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Cells in every epithelium can be roughly divided in three compartments: stem cell (SC) compartment, transient amplifying cell (TA) compartment and terminally differentiated (TD) compartment. Maturation of stem cells is characterized by epithelial stromal interaction and sequential maturational movement of stem cell’s progeny through those compartments.
16p vischultz 20-10-2023 5 1 Download
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Transcription factor-dependent cellular reprogramming is integral to normal development and is central to production of induced pluripotent stem cells. This process typically requires pioneer transcription factors (TFs) to induce de novo formation of enhancers at previously closed chromatin. Mechanistic information on this process is currently sparse.
16p viaristotle 29-01-2022 16 1 Download
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To define alterations in epigenetic landscapes in breast cancers, we profiled the distributions of 8 key histone modifications by ChIP-Seq, as well as primary (GRO-seq) and steady state (RNA-Seq) transcriptomes, across 13 distinct cell lines that represent 5 molecular subtypes of breast cancer and immortalized human mammary epithelial cells.
11p vibeauty 23-10-2021 13 0 Download
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P63, a member of the p53 gene family, is an important regulator for epithelial tissue growth and development. ΔNp63α is the main isoform of p63 and highly expressed in Non-melanoma skin cancer (NMSC).
12p vianrose2711 27-04-2021 9 1 Download
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Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vascular remodeling and obstruction of the epithelial-mesenchymal transition (EMT).
10p vichaeng2711 29-04-2021 9 1 Download
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Chemical investigation of the lichen Parmotrema praesorediosum (Nyl.) Hale led to isolate six phenolic compounds including praesorediosic (1), orcinol (2), orselinic acid (3), lecanorin (4), isolecanoric acid (5) and virensic acid (6). Among them, compound 1 appeared to be found for the first time in the nature. The structure of these compounds was elucidated by spectroscopic analyses of HRESIMS and NMR as well as the comparison of their NMR data with those in the literature.
5p nguaconbaynhay11 16-04-2021 20 1 Download
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Their structures were established by means of physical data (ESI MS, 1D and 2D NMR) and evaluated for the cytotoxic activities against liver hepatocellular carcinoma (HepG2), human lung cancer (NCI-H460), human epithelial carcinoma (HeLa) and human breast cancer (MCF-7) cell lines. This is the first report on phytochemical studies of this plant.
5p nguaconbaynhay11 16-04-2021 20 2 Download
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In the present study the ethanol extracts of Capparis sepiaria, Euphorbia heterophylla and Tamilnadia uliginosa leaf were tested for cytotoxic activity against three different human cancer cell lines such as HeLa cervical cancer cell line, MCF-7 human breast adenocarcinoma cell line and A-549 Human lung adenocarcinoma epithelial cell line, and compared with vero normal cell line.
7p angicungduoc8 07-11-2020 6 1 Download
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Cancer stem cells (CSC) are believed to play a crucial role in cancer recurrence due to their resistance to conventional chemotherapy and capacity for self-renewal. Recent studies have reported that salinomycin, a livestock antibiotic, selectively targets breast cancer stem cells 100-fold more effectively than paclitaxel. In our study we sought to determine the effects of salinomycin on head and neck squamous cell carcinoma (HNSCC) stem cells.
14p vijisoo2711 30-09-2020 12 1 Download
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Mesenchymal stromal cells (MSCs) represent heterogeneous cell population suitable for cell therapies in regenerative medicine. MSCs can also substantially affect tumor biology due to their ability to be recruited to the tumor stroma and interact with malignant cells via direct contacts and paracrine signaling.
13p vijennie2711 29-09-2020 11 1 Download
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We are using ACI and BN rats, which differ markedly in their susceptibility to 17β-estradiol (E2)-induced mammary cancer, to identify genetic variants and environmental factors that determine mammary cancer susceptibility.
15p vijennie2711 29-09-2020 8 2 Download
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Heregulin (HRG; also known as neuregulin) is a ligand for ErbB3. One of its isotypes, HRG-β1, binds to ErbB3 and forms heterodimers with other ErbB family members, thereby enhancing the proliferation and tumorigenesis of breast cancer cells.
10p vijennie2711 29-09-2020 10 0 Download
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The Odontogenic Ameloblast-associated Protein (ODAM) is expressed in a wide range of normal epithelial, and neoplastic tissues, and we have posited that ODAM serves as a novel prognostic biomarker for breast cancer and melanoma. Transfection of ODAM into breast cancer cells yields suppression of cellular growth, motility, and in vivo tumorigenicity.
11p vijennie2711 29-09-2020 11 1 Download
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The X-linked ribosomal protein S4 (RPS4X), which is involved in cellular translation and proliferation, has previously been identified as a partner of the overexpressed multifunctional protein YB-1 in several breast cancer cells. Depletion of RPS4X results in consistent resistance to cisplatin in such cell lines.
12p vijennie2711 29-09-2020 11 0 Download
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While glucocorticoids and the liganded glucocorticoid receptor (GR) have a well-established role in the maintenance of differentiation and suppression of apoptosis in breast tissue, the involvement of unliganded GR in cellular processes is less clear.
19p virose2711 24-09-2020 14 1 Download
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Mammary microcalcifications have a crucial role in breast cancer detection, but the processes that induce their formation are unknown. Moreover, recent studies have described the occurrence of the epithelial–mesenchymal transition (EMT) in breast cancer, but its role is not defined.
10p virose2711 24-09-2020 8 0 Download
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Triple negative breast cancer (TNBC) has higher rates of recurrence and distant metastasis, and poorer outcome as compared to non-TNBC. Aberrant activation of WNT signaling has been detected in TNBC, which might be important for triggering oncogenic conversion of breast epithelial cell.
13p virose2711 25-09-2020 13 1 Download