Breast tumour biology
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Stage shift is widely considered a major determinant of the survival benefit conferred by breast cancer screening. However, factors and mechanisms underlying such a prognostic advantage need further clarification. We sought to compare the molecular characteristics of screen detected vs. symptomatic breast cancers and assess whether differences in tumour biology might translate into survival benefit.
11p vijisoo2711 29-09-2020 10 1 Download
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Our retrospective, international study aimed at evaluating the activity and safety of eribulin mesylate (EM) in pretreated metastatic breast cancer (MBC) in a routine clinical setting. Patients treated with EM for a locally advanced or MBC between March 2011 and January 2014 were included in the study.
9p viamsterdam 18-09-2020 7 0 Download
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The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this retrospective multicentre study was to evaluate if and how different variables such as primary tumour stage, biological and histological subtype, age at primary diagnosis, tumour size, the number of affected lymph nodes as well as grading influence the development of bone-only metastases.
13p vinaypyidaw2711 26-08-2020 20 2 Download
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The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in human cancer cells.
12p vidhaka2711 31-07-2020 8 1 Download
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Male breast cancer (MBC) represents a poorly characterised group of tumours, the management of which is largely based on practices established for female breast cancer. However, recent studies demonstrate biological and molecular differences likely to impact on tumour behaviour and therefore patient outcome.
11p vimanama2711 30-07-2020 8 2 Download
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Tumour-infiltrating lymphocytes (TILs) have been demonstrated to significantly influence prognosis and response to therapy of invasive breast cancer (IBC). Thus, it has been suggested that TIL density or/and immunophenotype could serve as biomarkers for selection of IBC patients for immunotherapy.
10p vibaku2711 22-07-2020 9 1 Download
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Human epidermal growth factor receptor HER3 (ErbB3), especially in association with its relative HER2 (ErbB2), is known as a key oncogene in breast tumour biology. Nonetheless, the prognostic relevance of HER3 remains controversial. NEDD4–1 and NRDP1 are signalling molecules closely related to the degradation of HER3 via ubiquitination.
19p vimanila2711 25-06-2020 9 1 Download
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The BCL-2 homology domain 3 (BH3)-only protein, B-cell lymphoma 2 interacting mediator of cell death (BIM) is a potent pro-apoptotic protein belonging to the B-cell lymphoma 2 protein family. In recent years, advances in basic biology have provided a clearer picture of how BIM kills cells and how BIM expression and activity are repressed by growth factor signalling pathways, especially the extracellular signal-regulated kinase 1⁄2 and protein kinase B pathways.
13p viettel02 20-02-2013 39 1 Download
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Survival rates vary with the biological characteristics of the tumour and the stage of development at which it is detected. About 50% of patients have early disease at the time of initial diagnosis (stage I, T1, N0 – tumour confined to breast)5 , for which the prognosis is excellent; fewer than 5% of patients have metastatic disease (stage IV) at this point, although the likelihood of an initial diagnosis of advanced breast cancer tends to increase with age.
47p taisaokhongthedung 07-01-2013 53 3 Download
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Fibroblast activation protein-a(FAP) is a cell surface-expressed and solu-ble enzyme of the prolyl oligopeptidase family, which includes dipeptidyl peptidase 4 (DPP4). FAP is not generally expressed in normal adult tissues, but is found at high levels in activated myofibroblasts and hepatic stellate cells in fibrosis and in stromal fibroblasts of epithelial tumours.
17p cosis54 05-01-2013 45 4 Download