Breast tumour
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Cryopreservation of human cancers conserves tumour heterogeneity for singlecell multi-omics analysis
High throughput single-cell RNA sequencing (scRNA-Seq) has emerged as a powerful tool for exploring cellular heterogeneity among complex human cancers. scRNA-Seq studies using fresh human surgical tissue are logistically difficult, preclude histopathological triage of samples, and limit the ability to perform batch processing.
17p vibransone 28-03-2024 1 1 Download
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Homologous recombination is a robust, broadly error-free mechanism of double-strand break repair, and deficiencies lead to PARP inhibitor sensitivity. Patients displaying homologous recombination deficiency can be identified using ‘mutational signatures’
24p vicwell 29-02-2024 7 2 Download
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Ebook A history of surgery (third edition): Part 2 includes content: The surgery of warfare, breast tumours, cutting for the stone, thyroid and parathyroid, thoracic and vascular surgery, organ transplantation,…and other contents.
142p longtimenosee03 01-02-2024 1 0 Download
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Part 2 book "Mouse as a model organism" includes content: Experimental tumour models in mice; exploration of mmp function in mouse models of angiogenesis; tumor stroma interactions - focus on fibroblasts; experimental procedures to assay invasion associated activities of primary cultured fibroblasts; systemic instigation - a mouse model to study breast cancer as a systemic disease.
77p muasambanhan03 25-12-2023 5 1 Download
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The tumour–stroma ratio (TSR) is identified as a promising prognostic parameter for breast cancer, but the cutof TSR value is mostly assessed by visual assessment, which lacks objective measurement. The aims of this study were to optimize the cutof TSR value, and evaluate its prognosis value in patients with breast cancer both as continuous and categorical variables.
11p vileonardodavinci 23-12-2023 3 3 Download
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Breast cancer is a major health burden for women, worldwide. Lifestyle-related risk factors, such as obesity and being overweight, have reached epidemic proportions and contributes to the development of breast cancer.
15p vileonardodavinci 23-12-2023 5 3 Download
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Cancer patients have an increased risk of developing venous thromboembolism, with up to 30% dying within a month of their development. Some cancer cells are known to induce platelet aggregation, and this interaction is understood to contribute to thrombosis and haematogenous metastasis.
12p vialfrednobel 23-12-2023 7 4 Download
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Breast cancer has become the most common malignant tumour worldwide. Distant metastasis is one of the leading causes of breast cancer-related death. To verify the performance of clinicomics-guided distant metastasis risk prediction for breast cancer via artificial intelligence and to investigate the accuracy of the created prediction models for metachronous distant metastasis, bone metastasis and visceral metastasis.
16p vischultz 20-10-2023 7 1 Download
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Recurrence and metastases are still frequent outcomes after initial tumour control in women diagnosed with breast cancer. Although therapies are selected based on tumour characteristics measured at baseline, prognostic biomarkers can identify those at risk of poor outcomes.
9p vischultz 20-10-2023 4 1 Download
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Breast cancer is a malignant tumour that seriously threatens women’s life and health and exhibits high inter-individual heterogeneity, emphasising the need for more in-depth research on its pathogenesis. While internal 7-methylguanosine (m7G) modifications affect RNA processing and function and are believed to be involved in human diseases, little is currently known about the role of m7G modification in breast cancer.
21p visharma 20-10-2023 4 2 Download
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Prehabilitation with exercise interventions during neoadjuvant chemotherapy (NACT) is effective in reducing physical and psychosocial chemotherapy-related adverse events in patients with cancer. The aim of the study here described is to investigate if supervised exercise with high-intensity aerobic and resistance training during NACT can improve tumour reduction in patients with breast cancer.
17p vioracle 29-09-2023 6 2 Download
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The clinical symptoms of infected dogs are very complex, including fever, abortion, joint pain, breast tumours, short breathing, nasal haemorrhage, weakness, pale mucosa, skin inflammation, hair loss around the eyes, eye discharges, cloudy eyes, refuging to eat, diarrhoea, belly skin haemorrhage, anorexia, constipation, ascites, vomiting, depression, salivation, and metritis.
12p vistarlord 15-06-2023 5 1 Download
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Response guided treatment in breast cancer is highly desirable, but the effectiveness is only estab‑ lished based on residual cellularity from histopathological analysis after surgery. Tubule formation, a key component of grading score, is directly associated with cellularity, with significant implications on prognosis.
12p vikolindagrabar 27-07-2022 5 1 Download
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Greater early life adiposity has been reported to reduce postmenopausal breast cancer risk but it is unclear whether this association varies by tumour characteristics. We aimed to assess associations of early life body size with postmenopausal breast cancer and its subtypes, allowing for body size at other ages.
9p viangelamerkel 27-07-2022 8 1 Download
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The aim of this study was to investigate the response of two canine mammary tumour cell lines, CIPp from a primary tumour and CIPm, from its lymph node metastasis, to exposure to EC50(20h) DOX at 12, 24 and 48 h of treatment. We assessed the uptake and subcellular distribution of DOX, the expression and function of P-glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP), two important MDR mediators.
15p vidarwin 23-02-2022 11 1 Download
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Although breast cancer is the most common cancer among Sri Lankan women, there is little published data on patient characteristics and treatment in the local context. We aimed to describe disease characteristics and management in a large contemporary cohort of women with breast cancer at the National Cancer Institute of Sri Lanka (NCISL).
8p vimahuateng 26-11-2021 4 0 Download
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Ovarian cycle stage critically affects 21- gene recurrence scores in Mmtv-Pymt mouse mammary tumours
The Oncotype DX 21-gene Recurrence Score is predictive of adjuvant chemotherapy benefit for women with early-stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. In premenopausal women, fluctuations in estrogen and progesterone during the menstrual cycle impact gene expression in hormoneresponsive cancers.
12p vimahuateng 26-11-2021 10 1 Download
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Cancer-associated fibroblasts (CAFs) are some of the most abundant components of the tumour microenvironment. A recent study suggested that in some cancers, CAFs express programmed death ligand 1 (PD-L1), which can act as a prognostic marker.
10p vianrose2711 27-04-2021 13 1 Download
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Overall survival of HER2 positive metastatic breast cancer patients has been significantly improved with inclusion of trastuzumab to chemotherapy. Several studies have demonstrated discordant HER2 status in the primary and metastatic tumour. However, rates of discordance vary considerably in published reports.
7p vijisoo2711 30-09-2020 15 1 Download
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Human tumour xenografts in immune compromised mice are widely used as cancer models because they are easy to reproduce and simple to use in a variety of pre-clinical assessments. Developments in nanomedicine have led to the use of tumour xenografts in testing nanoscale delivery devices, such as nanoparticles and polymer-drug conjugates, for targeting and efficacy via the enhanced permeability and retention (EPR) effect.
10p vijisoo2711 30-09-2020 10 1 Download