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Blood vessel hyperpermeability and pathophysiology in human tumour xenograft models of breast cancer: A comparison of ectopic and orthotopic tumours
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Human tumour xenografts in immune compromised mice are widely used as cancer models because they are easy to reproduce and simple to use in a variety of pre-clinical assessments. Developments in nanomedicine have led to the use of tumour xenografts in testing nanoscale delivery devices, such as nanoparticles and polymer-drug conjugates, for targeting and efficacy via the enhanced permeability and retention (EPR) effect.
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