Cancer drug discovery

Molecular targeted therapy using a drug that suppresses the growth and spread of cancer cells via inhibition of a spe‑ cifc protein is a foundation of precision medicine and treatment. High expression of the proto-oncogene Bcl-3 promotes the proliferation and metastasis of cancer cells originating from tissues such as the colon, prostate, breast, and skin.

12p vishanshan 27-06-2024 1 1   Download

This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also includes discussion of new areas such as biotechnology and nanoparticles.

117p vimeyers 29-05-2024 3 2   Download

Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.

323p ladongphongthanh1008 22-04-2024 3 3   Download

Ebook "Targeted therapies in cancer: Myth or Reality?" contributes to improve our approach to cancer drug discovery and, ultimately, to find new, more efficacious and better tolerated drugs for cancer patients. It provides an overview of diverse approaches ranging from drug discovery to cellular therapy. Although this change in paradigm has been useful, its entry into the clinical arena was associates with unforeseen problems including the emergence of resistance, unexpected side effects and failures.

200p ladongphongthanh1008 22-04-2024 7 1   Download

Ebook "Handbook of anticancer drugs from marine origin" also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

801p tudohanhtau1006 29-03-2024 3 1   Download

Ebook "Disruption of protein–protein interfaces: In search of new inhibitors" reviews the latest developments and future perspectives in drug discovery at protein-protein interfaces. The authors detail experimental and computational tools to tackle the subject and highlight the contribution of the Italian research community to the field. Evidence shows that blocking or modulating protein-protein interactions might lead to the development of useful new drugs.

166p coduathanh1122 27-03-2024 1 1   Download

Ebook "Autophagy in health and disease: Potential therapeutic approaches" cover autophagy and its potential applications on diseases ranging from obesity, osteoarthritis, pulmonary fibrosis, and inflammation, through ALS, Parkinson's, retinal degeneration, breast cancer, alcoholic liver disease and more. The final chapters round out the book with a discussion of autophagy in drug discovery and 'bench to bedside'.

182p lamquandat 28-12-2023 3 2   Download

Non-gestational choriocarcinoma (NGC) is a rare subtype of malignant germ cell tumour and there is no consensus on its treatment. The lack of suitable preclinical models for NGC is a challenge in drug discovery research.

12p vileonardodavinci 23-12-2023 4 2   Download

Part 2 book "Biomarkers in medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer, biomarkers of HIV, biomarkers of in vitro drug induced mitochondrial dysfunction, immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research, nanoscale techniques for biomarker quantification, immunodiagnostics with a focus on lateral flow point of care devices,.... and other contents.

312p oursky09 12-11-2023 3 2   Download

Part 2 book "Biomarkers - In medicine, drug discovery, and environmental health" includes content: Biomarkers of immunotoxicity; biomarkers in obstetric medicine; biomarkers in cancer; biomarkers of HIV; biomarkers of in vitro drug induced mitochondrial dysfunction; immunoassay based technologies for the measurement of biological materials used for biomarkers discovery and translational research; nanoscale techniques for biomarker quantification; immunodiagnostics with a focus on lateral flow point of care devices,... and other contents.

312p oursky07 23-10-2023 7 1   Download

High-throughput screening (HTS) of small molecule drug libraries has greatly facilitated the discovery of new cancer drugs. However, most phenotypic screening platforms used in the field of oncology are based solely on cancer cell populations and do not allow for the identification of immunomodulatory agents.

10p vischultz 20-10-2023 3 1   Download

The discovery of new anti-melanoma drugs with low side effect is urgently required in the clinic. Recent studies showed that morusin, a flavonoid compound isolated from the root bark of Morus Alba, has the potential to treat multiple types of cancers, including breast cancer, gastric cancer, and prostate cancer. However, the anti-cancer effect of morusin on melanoma cells has not been investigated.

16p vioracle 29-09-2023 4 2   Download

Cancer is one of the leading cause of death worldwide that cause a burden for the health system and economic of both developed and developing countries. Tubulin is a wellknown biochemical target in the field of cancer drug discovery. The inhibition of tubulinmicrotubule dynamics would result in the mitosis during cell division, thus, killing the cancerous cells.

10p viannee 02-08-2023 5 3   Download

Using electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including disease-specific gene expression and drug-protein interactions, provide mechanistic understanding.

12p visteverogers 24-06-2023 3 2   Download

Pancreatic cancer is one of the most lethal tumors. The aim of this study is to provide an effective therapeutic discovery platform for pancreatic cancer by establishing and characterizing patient-derived organoids (PDOs).

12p vikolindagrabar 27-07-2022 2 1   Download

Hypopharyngeal cancer is a relatively rare malignancy with poor prognosis. Current chemotherapeutic algorithm is still far from personalized medicine, and the identification of the truly active therapeutic biomarkers and/ or targets is eagerly awaited.

16p vikolindagrabar 27-07-2022 1 1   Download

We show that variability in general levels of drug sensitivity in pre-clinical cancer models confounds biomarker discovery. However, using a very large panel of cell lines, each treated with many drugs, we could estimate a general level of sensitivity to all drugs in each cell line. By conditioning on this variable, biomarkers were identified that were more likely to be effective in clinical trials than those identified using a conventional uncorrected approach.

11p viaristotle 29-01-2022 8 0   Download

Massive genome sequencing data have inspired new challenges in personalized treatments and facilitated oncological drug discovery. We present a comprehensive database, My Personal Mutanome (MPM), for accelerating the development of precision cancer medicine protocols.

18p viarchimedes 26-01-2022 8 1   Download

Systematic in vitro loss-of-function screens provide valuable resources that can facilitate the discovery of drugs targeting cancer vulnerabilities. Results: We develop a deep learning-based method to predict tumor-specific vulnerabilities in patient samples by leveraging a wealth of in vitro screening data. Acquired dependencies of tumors are inferred in cases in which one allele is disrupted by inactivating mutations or in association with oncogenic mutations.

24p viarchimedes 26-01-2022 8 1   Download

Traditional cancer treatments have centered on cytotoxic drugs and general purpose chemotherapy that may not be tailored to treat specific cancers. Identification of molecular markers that are related to different types of cancers might lead to discovery of drugs that are patient and disease specific.

12p vikentucky2711 24-11-2020 12 2   Download