Cancer therapy

Evaluate the initial treatment results of non-small cell lung cancer with EGFR and ALK concurrent mutations. Subjects and methods: A prospective study, non-controlled description, and longitudinal follow-up of 6 patients with stage IIIB-IV non-small cell lung cancer, with EGFR and ALK concurrent mutations, at the National Lung Hospital, from January 2022 to July 2023.

5p vipanly 28-10-2024 0 0   Download

The aim of the present study was to investigate the anti-colorectal cancer effect of the DNA-PK inhibitor NU7441, which inhibits DNA-DSB repair by blocking the NHEJ pathway, in the HCT116 cell line.

7p viengfa 29-09-2024 2 2   Download

The main reason is the persistence of cancer cells after treatment. Detecting minimal residual disease is considered as “gold standard” in evaluating treatment efficiency, selecting alternative therapies, and predicting relapse in leukemic management.

5p vifaye 20-09-2024 2 1   Download

Evaluate the effectiveness of pain relief due to bone metastasis using external beam radiation therapy technique. Subjects and Methods: Retrospective and prospective study describing 178 patients with stage IV cancer, bone metastases, treated for pain relief with external radiotherapy, at the Institute of Oncology and Nuclear Medicine, Hospital Military Medicine 175, from May 2021 to April 2022.

9p viavatis 29-08-2024 3 1   Download

To evaluate the effectiveness of radiotherapy on overall survival (OS) and identify factors affecting survival outcomes in patients with stage III non-small cell lung cancer (NSCLC) where surgery is not feasible.

11p viavatis 29-08-2024 4 1   Download

To describe the characteristics of patients with HER2-positive breast cancer and to identify the proportion of patients using anti-HER2 therapy, and treatment-making related factors. An analytical cross-sectional study was conducted on 79 patients with BC and HER2-positive diagnosed by immunohistochemistry (IHC) or with FISH at the Oncology Department of Hue University of Medicine and Pharmacy Hospital and Oncology Center of Hue Central Hospital from 1/2021 to 12/2022.

8p vinatisu 29-08-2024 2 0   Download

Secondary upper limb lymphedema is a common complication after breast cancer treatment. Among the treatment methods, conservative treatment with complex decongestive therapy brings positive results to patients and it is non - invasive.

6p vinatisu 29-08-2024 1 1   Download

Sleep disorders and insomnia are frequent concerns among cancer survivors, presenting a notable challenge. Herbal footbaths are a complementary and alternative medicine that provides good results in managing insomnia, with few adverse effects and low costs. This study aims to assess the effectiveness and safety of herbal footbaths therapy for insomnia treatment in cancer patients.

6p vinatisu 29-08-2024 4 1   Download

Brain metastasis is common in patients with non-small cell lung cancer (NSCLC) and it is associated with poorer prognosis. Several options to control the secondary brain tumors in the context include chemotherapy, whole-brain radiation, stereotactic surgery, surgery. However, chemotherapy is ineffective to those patients because of poor penetration through the blood-brain barrier. Whole-brain radiation therapy used to be a standard option for brain metastases.

5p vinatisu 29-08-2024 5 2   Download

This study presents the development of a software support system aimed at improving targeted treatment outcomes in non-small cell lung cancer (NSCLC) by utilizing genetic mutation analysis data. PubMed BERT model were generated to identify tumor gene mutated features associated with gene-drug responses.

14p vinatisu 23-08-2024 4 1   Download

Human epidermal growth factor receptor 2 (HER2) has been identified as a molecular target for breast cancer therapy, such as Trastuzumab (Herceptin®). This has been shown to improve patient survival substantially.

10p vibego 02-02-2024 7 0   Download

Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic options for ovarian cancer are far from satisfactory, leading to high diagnosis rates at late stages and disease relapses. New avenues of therapy are needed that target key processes in ovarian cancer progression.

20p vimichaelfaraday 25-03-2022 16 1   Download

The aim of this prospective phase II study was to evaluate the efficacy and safety of biweekly docetaxel plus androgen-deprivation therapy (ADT) in patients with metastatic castration-naïve prostate cancer (mCNPC).

7p vielonmusk 21-01-2022 9 1   Download

Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies.

13p vielonmusk 21-01-2022 11 0   Download

The clinical outcome of Philadelphia chromosome-negative B cell acute lymphoblastic leukemia (Phneg B-ALL) varies considerably from one person to another after clinical treatment due to lack of targeted therapies and leukemia’s heterogeneity.

16p vielonmusk 21-01-2022 9 0   Download

Neoadjuvant therapy followed by surgery is recommended for locally advanced esophageal cancer. With the inaccuracies of clinical staging particularly for cT1N+ and cT2Nany tumors, some have proposed consideration of surgery followed by adjuvant treatment.

9p vielonmusk 21-01-2022 16 0   Download

The ESR1 gene encodes Estrogen Receptor alpha (ERα), which plays a role in the tumourigenesis of breast cancer. A single nucleotide polymorphism (SNP) in intron 1 of this gene called ESR1 PvuII (rs2234693) has been reported to increase the risk of breast cancer. This study aimed to investigate the ESR1 PvuII polymorphism as a prognostic and predictive factor guiding the choice of therapy for advanced breast cancer.

7p vielonmusk 21-01-2022 39 1   Download

The aim of this study was to analyze the level of CD33 expression in patients with newly diagnosed AML and determine its correlation with clinical characteristics. Methods: Samples were collected for analysis from AML patients at diagnosis. We evaluated the level of CD33 expression by flow cytometry analysis of bone marrow.

7p vielonmusk 21-01-2022 16 2   Download

We sought to understand the clinical course and molecular phenotype of patients who showed disease progression after programmed cell death ligand 1 (PD-L1) inhibitor treatment but subsequently responded to PD-1 inhibitor treatment. We also explored the response to PD-1-axis targeted therapy of classical Hodgkin lymphoma (cHL) according to genetically driven PD-L1 and programmed cell death ligand 2 (PD-L2) expression.

8p vielonmusk 21-01-2022 15 1   Download

The mixed-lineage leukemia (MLL) gene is located on chromosome 11q23. The MLL gene can be rear‑ ranged to generate partial tandem duplications (MLL-PTD), which occurs in about 5-10% of acute myeloid leukemia (AML) with a normal karyotype and in 5-6% of myelodysplastic syndrome (MDS) patients. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently one of the curative therapies available for AML and MDS with excess blasts (MDS-EB).

11p vielonmusk 21-01-2022 11 1   Download