Central nervous system injury

Although there are over 400,000 people each year in the United States alone who suffer from traumatic injury to the central nervous system (CNS), no phar­ macological treatment is currently available. Considering the enormity of the problem in terms of human tragedy as well as the economic burden to families and societies alike, it is surprising that so little effort is being made to develop treatments for these disorders.

399p vimeyers 29-05-2024 3 2   Download

The human personality is inextricably bound up with, among other things, the function of the central nervous system. Diseases and malfunctions of the brain, head injuries and neurosurgical operations can all result in permanently altered behaviour patterns. This interrelation between brain and behaviour is most clearly demonstrated in cases involving functional neurosurgery and severe traumatic lesions.

179p vimeyers 29-05-2024 4 2   Download

Ebook "Endogenous stem cell-based brain remodeling in mammals" highlights the endogenous regenerative potential of the central nervous system in neonates and juveniles and discusses possible ways it might be manipulated for medical purposes. The first section provides a descriptive summary of the salient steps of human brain development with a discussion of comparisons with other mammalian brains. It also provides a historical perspective on our understanding of ongoing brain development throughout the lifespan and serve to introduce the concept of brain plasticity following injury.

234p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "Regenerative medicine and cell therapy" discusses cutting-edge science in the field of regenerative biomedicine and its therapeutic applications to various medical disorders. The chapters are written by renowned scientists in the specific fields. This will be a useful book for basic and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research.

322p ladongphongthanh1008 22-04-2024 3 1   Download

Part 2 book "Fetal and neonatal brain injury" includes content: Neurogenetic disorders of the brain, hemorrhagic lesions of the central nervous system, neonatal stroke, hypoglycemia in the neonate, hyperbilirubinemia and kernicterus, hydrops fetalis, bacterial sepsis in the neonate, neonatal bacterial meningitis, neurological sequelae of congenital perinatal infection, perinatal human immunodeficiency virus infection, inborn errors of metabolism with features of hypoxic–ischemic encephalopathy,... and other contents.

352p muasambanhan10 03-04-2024 4 2   Download

Part 2 book "Veterinary surgery - Small animal" includes content: Neurologic examination and neuroanatomic diagnosis, imaging of the neurologic system, pathogenesis and physiology of central nervous system disease and injury, medical conditions of the vertebral column and spinal cord,cervical vertebral column and spinal cord, thoracolumbar vertebral column, degenerative lumbosacral stenosis, vertebral fractures, luxations and subluxations, cranial surgery,... and other contents.

314p muasambanhan05 16-01-2024 6 0   Download

Part 3 book "The laboratory rat" includes content: General experimental techniques, integrating biology with rat genomic tools, gnotobiotics and the microbiome, toxicology, embryology and teratology, rat immunology, cardiovascular research, rat models of alcohol use disorder, rat models of obesity, metabolic syndrome, and diabetes, the rat in neuroscience research, rat models of central nervous system injury, use of the rat as a model in regenerative medicine, rat models of infectious disease.

393p oursky09 08-11-2023 4 2   Download

Sodium nitroprusside (SNP) is a potent vasodilator that has been used to induce deliberate hypotension in children during surgery involving significant blood loss, including craniofacial and spinal fusion procedures. SNP metabolism liberates cyanide, which may cause interference with cellular energy metabolism, leading to metabolic acidosis and central nervous system injury.

8p viisaacnewton 26-04-2022 15 1   Download

Nerve injury-induced neuropathic pain is a major health problem worldwide. Notch signaling is a highly conserved pathway in evolution, which has an important role in synaptic plasticity and inflammation in central nervous system. The present study was designed to investigate the potential role of notch signaling in the development of neuropathic pain.

7p viisaacnewton 26-04-2022 10 1   Download

Emerging evidence indicates that long noncoding RNAs (lncRNAs) are important regulators of various biological processes, and their expression can be altered following certain pathological conditions, including central nervous system injury. Retinal ganglion cells (RGCs), whose axons form the optic nerve, are a heterogeneous population of neurons with more than 40 molecularly distinct subtypes in mouse.

16p vilarryellison 29-10-2021 7 1   Download

The regenerative ability of severed axons in the central nervous system is limited in mammals. However, after central nervous system injury, neural function is partially recovered by the formation of a compensatory neural circuit. In a mouse pyramidotomy model, axonal sprouting of the intact side of the corticospinal tract is observed in the spinal cord, and the axons make new synapses with the denervated side of propriospinal neurons.

17p visilicon2711 20-08-2021 8 1   Download

The South African claw-toed frog, Xenopus laevis, is uniquely suited for studying differences between regenerative and non-regenerative responses to CNS injury within the same organism, because some CNS neurons (e.g., retinal ganglion cells after optic nerve crush (ONC)) regenerate axons throughout life, whereas others (e.g., hindbrain neurons after spinal cord injury (SCI)) lose this capacity as tadpoles metamorphose into frogs.

27p vijeeni2711 30-06-2021 10 1   Download

Planarians reliably regenerate all body parts after injury, including a fully functional head and central nervous system. But until now, the expression dynamics and functional role of miRNAs and other small RNAs during the process of head regeneration are not well understood.

11p vilichoo2711 25-06-2021 8 1   Download

Unlike mammals, zebrafish have a remarkable capacity to regenerate a variety of tissues, including central nervous system tissue. The function of macrophages in tissue regeneration is of great interest, as macrophages respond and participate in the landscape of events that occur following tissue injury in all vertebrate species examined.

17p vilichoo2711 25-06-2021 8 1   Download

Neurogenic Myositis Ossificans (NMO) is a rare disabling pathology characterized by peri-articular heterotopic ossifications following severe peripheral or central nervous system injuries. It results in ankylosis and vessels or nerves compressions.

8p vitennessee2711 02-02-2021 11 2   Download

Adult echinoderms can completely regenerate major parts of their central nervous system even after severe injuries. Even though this capacity has long been known, the molecular mechanisms that drive fast and complete regeneration in these animals have remained uninvestigated.

9p viwyoming2711 16-12-2020 4 1   Download

Technological advances provide an opportunity to refine tools that assess central nervous system performance. This study aimed to assess the test-retest reliability and convergent and ecological validity of a newly developed, virtual-reality.

10p vigeorgia2711 30-11-2020 14 1   Download

Unilateral weakness of an upper extremity is most frequently caused by traumatic nerve injury or compression neuropathy. In rare cases, lesion of the central nervous system may result in syndromes suggesting peripheral nerve damage by the initial examination.

5p vimanila2711 25-06-2020 7 1   Download

Spinal cord injury (SCI) remains a huge medical problem nowadays as there is no hospital providing the versatile strategies for repairing central nervous system and restoring function. Herein, we focused on PC-12 cells as an important research tool and studied the potential role of resveratrol (RSV) in inflammation induced by LPS.

9p vihamax2711 21-04-2020 12 0   Download

Astrocytes are responsible for numerous aspects of metabolic support, nutrition, control of the ion and neurotransmitter environment in central nervous system (CNS). Failure by astrocytes to support essential neuronal metabolic requirements plays a fundamental role in the pathogenesis of brain injury and the ensuing neuronal death.

10p vienzym2711 03-04-2020 9 1   Download