Chemotherapy for childhood

A select number of relatively rare metastatic malignancies comprising trophoblast tumours, the rare childhood cancers, germ cells tumours, leukemias and lymphomas have been routinely curable with chemotherapy for more than 30 years. However for the more common metastatic malignancies chemotherapy treatment frequently brings clinical benefits but cure is not expected.

25p vialabama2711 21-09-2020 10 1   Download

The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse effects of chemotherapy

14p vibaku2711 22-07-2020 5 1   Download

There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the goal is to conduct a phase I study of olaparib, a poly(ADP-ribose) polymerase inhibitor.

7p vidublin2711 13-01-2020 8 0   Download

Tham khảo tài liệu 'user’s guide posters (ink-jet color plotter for a2 to a0 formats)', công nghệ thông tin, đồ họa - thiết kế - flash phục vụ nhu cầu học tập, nghiên cứu và làm việc hiệu quả

10p seketnoi 29-04-2013 45 3   Download

The studies confirmed the glucose-lowering benefits of metformin in combination with all other available glucose-lowering medications. The widespread use of the previous recommendations in regard of levels of serum creatinine for reduction and discontinuing therapy was acknowledged. The complete substitution of estimated glomerular filtration rate (eGFR) for serum creatinine is not possible because of uncertainty surrounding methods of eGFR calculation in many people with Type 2 diabetes.

25p dacotaikhoan 26-04-2013 37 1   Download

In spring 2010, the kitchen table room at Tru was transformed into Michigan Avenue’s newest burger joint called M Burger. Guests could walk up to this affordable burger counter and enjoy single and double burgers along with the signature “M Burger” topped with bbq sauce, bacon and secret sauce. In Las Vegas, things were heating up with the opening of El Segundo Sol serving up their signature tacos and margaritas. As the summer of 2010 came to a close, a second M Burger opened at 5 W. Ontario Street. Like the first, it was carved out of an existing LEYE...

32p loginnhanh 25-04-2013 53 6   Download

In real life, we can tell where objects are by measuring distance between them. As for placing them, moving them, and keeping track of where they are nature has developed a pretty good system. On the computer though, we have to somehow keep track of objects in a 3D scene. Mathematicians have developed the coordinate system. You have probably learned in geometry about the X and the Y axis. Well, these two axis define a coordinate plane, that is, a two dimentional world. However, to work in three dimentions, we need one more axis, the Z axis....

0p hoangphiyeah1tv 24-04-2013 44 2   Download

Certain mechanisms have been identified by which remittances might not have beneficial effects on development or might even become counterproductive. First, remittances can lead to higher levels of imbalance in countries that are already suffering from an unequal distribution of income. This happens when migratory movements are highly concentrated in areas and socio-economic groups that, furthermore, are not the most vulnerable in the country. As it is the migrants’ families that receive the remittances, this concentration phenomenon becomes more intense.

42p hoangphiyeah1tv 18-04-2013 42 4   Download

A within-subjects analysis was used to reduce any variability that may have been attributed to differences between subjects: thus, each subject’s performance on one layout was compared with his or her own performance on an alternative layout. The practice diagrams and the randomisation of the order of presentation of the experimental diagrams for each subject helped counter the learning effect (whereby subjects’ performance on the task may improve over time, as they become more competent in the task).

22p giamdocamnhac 06-04-2013 55 2   Download

Hollywood submitted to the rigorous oversight of the PCA because the alternatives to “censorship at the source” were far worse. After all, censorship had been a fact of creative and commercial life for motion picture producers from the very birth of the medium, when even the modest osculations of the middle-aged lovebirds in Thomas Edison’s The Kiss (1896) scandalized cadres of (literally) Victorian ministers, matrons, and other variants of a sour-faced species known as the “bluenose.

78p hongphuocidol 03-04-2013 82 7   Download

The decision-making process outlined in this handbook assume that you will seek com- petitive bids or award a sole-source contract. These two methods are highly recommended for works of art because potential contractors will be judged on the quality of their work and appropriateness of their background. Soliciting competitive bids is preferable if you are just beginning to work with conserva- tors, if the project is large or long-term, or if you are required to solicit bids.

6p yasuyidol 01-04-2013 40 4   Download

In classification, we wish to construct a model from a set of historical data. The model should describe a predetermined set of data classes. For example, in traditional direct marketing there are usually two predetermined classes, namely the “responder” class and the “non-responder” class. An observation or sample is a record representing an entity, e.g. a customer. Each observation is associated with a certain number of characteristic attributes and belongs to exactly one of the predetermined classes.

36p lenh_hoi_xung 21-02-2013 43 4   Download

Even in work that lies so near the fortuities of animate nature as dairying, stock−breeding, and the improvement of crop plants, a determinate, reasoned routine replaces the rule of thumb. By mechanical control of his materials the dairyman, e.g., selectively determines the rate and kind of the biological processes that change his raw material into finished product.

64p bi_ve_sau 05-02-2013 42 5   Download

An economy’s trade patterns create one channel for the cross-border transmission of shocks. While the average economy in our data had a current account very close to zero in 2007, the range is quite large. Trade openness, measured by the ratio of the sum of exports plus imports to GDP, captures the importance of trade. The average in our data is 98% of GDP, but the standard deviation of 66 percentage points implies a wide distribution. Finally, a country’s natural endowment may play a role in its macroeconomic performance.

21p doipassword 01-02-2013 56 2   Download

What a difference a few years can make! The financial crisis that engulfed mature economies in the late 2000s has prompted much soul searching. Economists are now trying hard to incorporate financial factors into standard macroeconomic models. However, the prevailing, in fact almost exclusive, strategy is a conservative one. It is to graft additional so-called financial “frictions” on otherwise fully well behaved equilibrium macroeconomic models, built on real-business-cycle foundations and augmented with nominal rigidities.

848p mebachano 01-02-2013 39 2   Download

In 2001, energy production in São Paulo, Brazil was highly constrained as a result of both severe drought and government energy tariff policies that favored the development of hydroelectric systems over thermal plants. In order to prevent blackouts, the government imposed quotas aimed at reducing energy consumption by 10-35 percent, based on the added value of particular industries and the number of jobs affected.

50p saimatkhauroi 01-02-2013 37 2   Download

Enter the amount of terminal loss relief you are claiming against your 2011–12 profits at box 73 on page SEF 4 or box 15 on the Partnership pages as a loss brought forward and used this year . This is in addition to any other losses you are bringing forward from earlier years, but make sure you do not count the same loss twice. Enter the total amount of terminal loss relief for 2010–11, 2009–10 or 2008–09 in box 78 on page SEF 4 or box 21 on the Partnership pages and give details of the amount carried back to each year in the ‘Any other information’...

12p taisaovanchuavo 26-01-2013 64 3   Download

The greatest triumph of microfinance is the demonstration that poor households can be reliable bank customers. The received wisdom at the start of the 1970s held that substantial subsidies were required to run financial institutions serving poor households in low-income countries. Government banks often shouldered the task of serving the poor, usually with a focus on farmers. However, most state-run banks were driven by political imperatives, and so they charged interest rates well below market rates and even then collected loan repayments only half- heartedly.

39p taisaovanchuavo 23-01-2013 58 6   Download

Banks worldwide are facing a crisis of confidence. According to a nationally representative survey in the US, less than half the customers had confidence in the financial security of banks – not a faith-inspiring number when you consider the fact that this survey was conducted a week before the Lehman Brothers filed for bankruptcy. The sub-prime fiasco, Madoff scandal and subsequent market downslide have destroyed customer faith and trust in financial institutions.

22p machuavo 19-01-2013 48 3   Download

The objective of this Work Area has been to undertake a detailed and itemised analysis based on population and sample analyses of the loan portfolios of the 14 banking groups included in the scope of the independent evaluation. This work has been undertaken by the four largest audit firms in Spain (Deloitte, PwC, Ernst & Young and KPMG). The 14 banking groups included in the exercise were assigned to each audit firm, and none of the audit firms reviewed banks audited by them in the last two financial years, in order to guarantee their independence. The assignment of...

14p machuavo 19-01-2013 35 2   Download