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Chronic myeloid leukemia
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In low-income countries there is insufficient evidence on hematological, clinical, cytogenetic and molecular profiles among new CML patients. Therefore, we performed this study among newly confirmed CML patients at Tikur Anbesa Specialized Hospital (TASH), Ethiopia.
10p
vishanshan
27-06-2024
1
1
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In the era of targeted therapies, the influence of aging on cancer management varies from one patient to another. Assessing individual frailty using geriatric tools has its limitations, and is not appropriate for all patients especially the youngest one.
8p
vikoch
27-06-2024
1
1
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Sleep-related painful erections are characterized by deep penile pain that occurs during erections in the rapid eye movement stage of sleep. We considered that the occurrence of sleep-related painful erections was related to chronic myeloid leukemia and the case might be secondary sleep-related painful erections.
5p
vitiki
30-01-2024
2
2
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A multicenter real-world evidence study in the Swiss treatment landscape of chronic myeloid leukemia
The real-world experience of Swiss chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKIs) is largely unknown, in particular with regard to achievement of response per European Leukemia Net (ELN) criteria and adherence to ELN recommendations.
13p
vileonardodavinci
23-12-2023
5
2
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The integrated stress response (ISR) facilitates cellular adaptation to unfavorable conditions by reprogramming the cellular response. ISR activation was reported in neurological disorders and solid tumors; however, the function of ISR and its role as a possible therapeutic target in hematological malignancies still remain largely unexplored.
17p
vileonardodavinci
23-12-2023
4
3
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Chronic myeloid leukemia (CML) is effectively treated with tyrosine kinase inhibitors (TKIs), targeting the BCR::ABL1 oncoprotein. Still, resistance to therapy, relapse after treatment discontinuation, and side effects remain significant issues of long-term TKI treatment. Preliminary studies have shown that targeting oxidative phosphorylation (oxPhos) and the unfolded protein response (UPR) are promising therapeutic approaches to complement CML treatment.
12p
vileonardodavinci
23-12-2023
2
2
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Myelodysplastic syndromes (MDS) are clonal hematopoietic diseases of the elderly characterized by chronic cytopenias, ineffective and dysplastic haematopoiesis, recurrent genetic abnormalities and increased risk of progression to acute myeloid leukemia.
10p
vialfrednobel
23-12-2023
4
3
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Telomere dysfunction results in aneuploidy, and ongoing chromosomal abnormalities. The threedimensional (3D) nuclear organization of telomeres allows for a distinction between normal and tumor cells. On the other hand, aurora kinase genes (AURKA and AURKB) play an important role regulating the cell cycle.
11p
vialfrednobel
23-12-2023
5
3
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Part 2 book "Veterinary comparative hematopathology" includes content: T-Cell and NK-Cell neoplasms, acute myeloid leukemias, chronic myeloproliferative diseases, myeloproliferative/Myelodysplastic diseases, myelodysplastic syndromes, hodgkin’s lymphoma, histiocytoses.
284p
oursky07
24-10-2023
7
4
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Part 2 book "Quantitative real-time PCR - Methods and protocols" includes content: Real-Time PCR detection of mycoplasma pneumoniae in the diagnosis of community acquired pneumonia, a sensible technique to detect mollicutes impurities in human cells cultured in GMP condition, real time quantification assay to monitor BCR ABl1 transcripts in chronic myeloid leukemia, a reliable assay for rapidly defining transplacental metastasis using quantitative PCR,... and other contents.
129p
oursky05
20-09-2023
5
1
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Abelson (ABL) tyrosine kinase inhibitors (TKIs) are effective against chronic myeloid leukemia (CML); however, many patients develop resistance during ABL TKI therapy. Vitamin K2 (VK2) is a crucial fat-soluble vitamin used to activate hepatic coagulation factors and treat osteoporosis.
11p
vioracle
29-09-2023
4
2
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Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by a reciprocal translocation between the long arms of chromosomes 9 and 22 that results in expression of the oncoprotein BCR-ABL1.
6p
viintuit
26-09-2023
3
0
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Chronic myeloid leukemia (CML) is a myeloproliferative disorder with clonal proliferation of all myeloid cell lines. The disease typically manifests in three phases: chronic course followed by an accelerated phase and finally a terminal blast crisis.
4p
viintuit
26-09-2023
3
0
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Chronic myeloid leukemia (CML) is a chronic myeloproliferative neoplasm characterized by excess granulocytes at different stages of maturation and the presence of BCR-ABL1 fusion gene or Philadelphia chromosome. Absolute eosinophilia, basophilia, and monocytosis are not uncommon in CML.
5p
viintuit
26-09-2023
1
0
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Myeloid leukemia (ML) is a cancer of the blood that begins when cells of the myeloid lineage uncontrollably change and grow. Acute myeloid leukemia (AML) is a disorder of rapid, uncontrolled growth of immature myeloid cells in the blood and bone marrow. Chronic myeloid leukemia (CML) is characterized by the aberrant proliferation of myeloid cells and driven by the translocation of regions of the BCR and ABL genes to form the Philadelphia (Ph) chromosome.
8p
vimulcahy
18-09-2023
6
3
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Lơ xê mi kinh dòng bạch cầu hạt (Chronic Myeloid Leukemia - CML) là bệnh ác tính hệ tạo máu, đặc trưng bởi sự tăng sinh quá mức dòng bạch cầu hạt đã biệt hoá, hậu quả là số lượng bạch cầu hạt tăng cao ở máu ngoại vi với đủ các lứa tuổi dòng bạch cầu hạt. Bài viết phân tích một số yếu tố liên quan đến tuân thủ điều trị của người bệnh lơ xê mi kinh dòng bạch cầu hạt điều trị ngoại trú tại Viện Huyết học-Truyền máu Trung ương, năm 2022.
5p
videadpool
05-05-2023
3
3
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Genome variability of host genome and cancer cells play critical role in diversity of response to existing therapies and overall success in treating oncological diseases. In chronic myeloid leukemia targeted therapy with tyrosine kinase inhibitors demonstrates high efficacy in most of the patients.
6p
vinarcissa
21-03-2023
4
1
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Cytochrome P450 (CYP) and glutathione S transferases (GSTs) are important biotransforming enzymes responsible for detoxifcation of anticancer drugs and carcinogens. Polymorphisms in these enzymes may greatly influence the susceptibility to CML and overall efficacy of tyrosine kinase inhibitors.
11p
viangelamerkel
27-07-2022
4
2
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Imatinib is the gold standard for the treatment of all phases of Philadelphia positive Chronic Myeloid Leukemia (CML). During treatment, patients may develop cytopenia. We aimed to study the baseline characteristics and factors associated with cytopenia at a Nairobi Hospital.
7p
vipriyankagandhi
27-07-2022
5
1
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This report summarizes three phase I studies evaluating volasertib, a polo-like kinase inhibitor, plus azacitidine in adults with myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia.
9p
visusanwojcicki
28-06-2022
12
2
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