Circular RNA

Circular RNAs (circRNAs) are more stable than linear RNA molecules, which makes them promising diagnostic biomarkers for diseases. By circRNA-sequencing analysis, we previously found that circN4BP2L2 was significantly decreased in epithelial ovarian cancer (EOC) tissues, and was predictive of disease progression.

15p vielonmusk 21-01-2022 25 0   Download

DiGIR2 is the group I splicing-ribozyme of themobile twin-ribozyme intron Dir.S956-1,present in Didymiumnuclear ribosomal DNA. DiGIR2 is responsible for intron excision, exon ligation,3¢-splice site hydrolysis,and full-length intron RNA circle formation. We recently reported that DiGIR2 splicing (intron excision and exon ligation) competes with hydrolysis and subsequent full-length intron circularization. Herewe present experimental evidence that hydrolysis at the 3¢-splice site in DiGIR2 is dependent on structural elements within the P9 subdomain not involved in splicing....

10p dell39 03-04-2013 40 4   Download