Clinical phenotypes

Phenotypic approach in the treatment of COPD is lacking in general medical facilities, despite the importance of this data. Objectives: The study aimed to identify divergences in features, pharmacologic regimens of COPD by clinical phenotypes in the real-life context of care units in Can Tho City that manage outpatients with chronic respiratory diseases.

8p viakimichi 17-01-2025 3 2   Download

Two novel rare mutations, MCAD
842GfiC (R256T) and MCAD
1166AfiG (K364R), have been investigated to assess how far the bio-chemical properties of the mutant proteins correlate with the clinical phenotype of medium chain acyl-CoA dehydrogenase (MCAD) deficiency. When the gene for K364R was overexpressed inEscherichia coli, the syn-thesized mutant protein only exhibited activity when the gene for chapero-nin GroELS was co-overexpressed.

9p fptmusic 12-04-2013 45 2   Download

The high water permeability of certain biological membranes is due to the presence of aquaporin water channel proteins. AQP1 was discovered in human red cells. AQP1 has been thoroughly characterized biophysically, and the atomic structure of AQP1 has been elucidated. Ten homologs have been identified in humans. These are selectively permeated by water (aquaporins) or water plus glycerol (aquaglyceroporins). The sites of expres-sion predict the clinical phenotypes in humans. Individuals lack-ing Colton blood group antigens have mutations in the AQP1 gene. ...

81p fptmusic 11-04-2013 43 4   Download

Despite the unique phenotypic properties and clinical importance ofPeni-cillium marneffei, the polyketide synthase genes in its genome have never been characterized. Twenty-three putative polyketide synthase genes and two putative polyketide synthase nonribosomal peptide-synthase hybrid genes were identified in theP.

9p viettel02 19-02-2013 39 5   Download

HIV-1 V3 envelope deep sequencing for clinical plasma specimens failing in phenotypic tropism assays

6p toshiba23 18-11-2011 37 2   Download

Opioid analgesics such as morphine and meperidine have been used to control moderate to severe pain for many years. However, these opioids have many side effects, including the development of tolerance and dependence after long-term use, which has limited their clinical use. We previously reported that mutations in the muopioid receptors (MOR) S196L and S196A rendered them responsive to the opioid antagonist naloxone without altering the agonist phenotype. In MORS196A knock-in mice, naloxone and naltrexone were antinociceptive but did not cause tolerance or physical dependence.

6p toshiba23 18-11-2011 53 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Novel autoantibodies and clinical phenotypes in adult and juvenile myositis...

7p thulanh15 21-10-2011 36 4   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency...

8p toshiba12 21-10-2011 71 6   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Exhaled nitric oxide and clinical phenotypes of childhood asthma...

8p toshiba11 20-10-2011 57 4   Download