Clonal multiplication
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There are multiple existing and emerging therapeutic avenues for metastatic prostate cancer, with a common denominator, which is the need for predictive biomarkers. Circulating tumor DNA (ctDNA) has the potential to cost-efficiently accelerate precision medicine trials to improve clinical efficacy and diminish costs and toxicity. However, comprehensive ctDNA profiling in metastatic prostate cancer to date has been limited.
13p vibransone 28-03-2024 3 2 Download
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Small intestinal neuroendocrine tumors (SI-NETs) are the most common neoplasms of the small bowel. The majority of tumors are located in the distal ileum with a high incidence of multiple synchronous primary tumors. Even though up to 50% of SI-NET patients are diagnosed with multifocal disease, the mechanisms underlying multiple synchronous lesions remain elusive.
12p viellison 28-03-2024 1 1 Download
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Mutations in the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), encoded by the PIK3CA gene, cause dysregulation of the PI3K pathway in 35–40% of patients with HR+/HER2– breast cancer.
14p vicwell 29-02-2024 7 1 Download
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Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sampled populations, diluting the signals of clone-specific aberrations, and complicating estimation of clone-specific genotypes.
14p vialfrednobel 29-01-2022 12 0 Download
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Immune checkpoint blockade (ICB) therapy has improved patient survival in a variety of cancers, but only a minority of cancer patients respond. Multiple studies have sought to identify general biomarkers of ICB response, but elucidating the molecular and cellular drivers of resistance for individual tumors remains challenging.
28p viarchimedes 26-01-2022 10 0 Download
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Increased reports of Neisseria meningitidis urethritis in multiple U.S. cities during 2015 have been attributed to the emergence of a novel clade of nongroupable N. meningitidis within the ST-11 clonal complex, the “U.S. NmNG urethritis clade”. Genetic recombination with N. gonorrhoeae has been proposed to enable efficient sexual transmission by this clade. To understand the evolutionary origin and diversification of the U.S. NmNG urethritis clade, whole-genome phylogenetic analysis was performed to identify its members among the N.
15p vibeauty 23-10-2021 9 0 Download
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The parthenogenetic Caucasian rock lizard Darevskia armeniaca, like most other parthenogenetic vertebrate species, originated through interspecific hybridization between the closely related sexual Darevskia mixta and Darevskia valentini.
12p viseulgi2711 31-08-2021 8 1 Download
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The synovial membrane adjacent to the articular cartilage is home to synovial mesenchymal progenitor cell (sMPC) populations that have the ability to undergo chondrogenesis. While it has been hypothesized that multiple subtypes of stem and progenitor cells exist in vivo, there is little evidence supporting this hypothesis in human tissues.
12p vivermont2711 28-01-2021 13 2 Download
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A study was carried out to establish efficient and reliable in vitro propagation protocol for Gisela 5 (Prunus cerasus x Prunus canescens) - clonal cherry rootstock. Axillary and terminal buds of ‘Gisela 5’ were collected in the spring and cultured on MS medium. After the in vitro cultures were sufficiently established, experiments were conducted to assess the influence of different levels of benzyladenine (BA), kinetin (Kin), thidiazuron (TDZ), gibrellic acid (GA3) and indole-3-butyric acid (IBA) on in vitro shoot multiplication.
8p angicungduoc8 07-11-2020 9 3 Download
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Deep sequencing of lymphocyte receptor repertoires has made it possible to comprehensively profile the clonal composition of lymphocyte populations. This opens the door for novel approaches to diagnose and prognosticate diseases with a driving immune component by identifying repertoire sequence patterns associated with clinical phenotypes.
10p viflorida2711 30-10-2020 9 2 Download
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The present investigation was emphasized on development of an efficient in vitro micropropagation protocol for high frequency mass multiplication of true-to-type plants and to detect the genetic uniformity of micropropagated plants of Stevia using molecular markers.
13p nguathienthan8 20-10-2020 12 2 Download
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Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses.
7p vimoscow2711 29-08-2020 9 2 Download
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Pointed gourd (Trichosanthes dioica Roxb.) is one of the important nutritive cucurbit perennial vegetables in India and other tropical countries. In the present investigation, an efficient and reproducible protocol for clonal multiplication through in vitro culture of Pointed gourd (Trichosanthes dioica Roxb.) is standardized.
9p kethamoi7 26-08-2020 11 2 Download
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The treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL) patients who harbor the T315I BCR-ABL1 mutation or who have two or more mutations in the same BCR-ABL1 molecule is particularly challenging since first and second-generation Tyrosine Kinase Inhibitors (TKIs) are ineffective.
6p vidhaka2711 31-07-2020 6 1 Download
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The genetic fidelity of in vitro raised gerbera plants multiplied through micropropagation upto fifteen in vitro subcultures was assessed by using intersimple sequence repeat (ISSR) markers. 40 ISSR primers screened, 20 ISSR primers produced a total of 54 ISSRs clear, distinct and reproducible amplicons, which were monomorphic across all micropropagated plants (15) studied. Thus, a total 1094 bands were generated which exhibited homogeneous banding patterns with ISSR markers. All banding profiles from micropropagated plants were monomorphic and similar to those of the mother plant.
7p quenchua6 15-06-2020 18 2 Download
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Effect of plant growth regulators on rooting behavior of stem cuttings of terminalia chebula (Retz.)
The effect of IBA and IAA (Auxins) concentrations were examined to mass multiply plus trees of Terminalia chebula (Retz.) through vegetative propagation via rooting of stem cuttings. The experiment was conducted in a completely randomized design (CRD) with three replications, One year old leafless branch cuttings were taken from selected superior phenotypes from the surrounding environs of SHUATS, Allahabad.
8p cothumenhmong5 17-05-2020 12 1 Download
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Acute myeloid leukemia (AML) is a clonal disorder of hematopoietic progenitor cells and the most common malignant myeloid disorder in adults. Several gene mutations such as in NPM1 (nucleophosmin 1) are involved in the pathogenesis and progression of AML. The aim of this study was to identify genes whose expression is associated with driver mutations and survival outcome. Genotype data (somatic mutations) and gene expression data including RNA-seq, microarray, and qPCR data were used for the analysis. Multiple datasets were utilized as training sets (GSE6891, TCGA, and GSE1159).
12p trinhthamhodang1 14-11-2019 14 0 Download
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Prunus cerasus L. ‘Oblačinska’ sour cherry germplasm was established in vitro directly from in situ plants on different explant collection dates, enabling quick clonal multiplication and introduction to a rootstock breeding program. Rosette initiation of four investigated genotypes was possible from November to April on the medium containing Schenk and Hildebrandt (SH) macroelements, Murashige and Skoog (MS).
7p vikimsa 22-02-2019 18 1 Download
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This report deals with the successful clonal propagation of endangered T. turcica using rhizome cuttings and epicotyl explants. Rhizome cuttings were treated with α-naphthaleneacetic acid (NAA) or indole-3-butyric acid (IBA) before planting for vegetative multiplication.
7p vivant2711 15-02-2019 12 1 Download
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Cancer Cell Biology The treatment of most human cancers with conventional cytoreductive agents has been unsuccessful due to the Gompertzian-like growth kinetics of solid tumors (i.e., tumor growth is exponential in small tumors, with increasing doubling times as tumors expand; since conventional chemotherapeutic agents target proliferating cells, noncycling cells in large tumors are relatively resistant). Genetic instability is inherent in most cancer cells and predisposes to the development of intrinsic and acquired drug resistance. Thus, although tumors arise from a single cell (i.e.
5p konheokonmummim 03-12-2010 90 4 Download