Combination of evidence

Multiple studies have indicated that patients with high body mass index (BMI) may have favourable survival outcomes following treatment with an immune checkpoint inhibitor (ICI). However, this evidence is limited by several factors, notably the minimal evidence from randomised controlled trials (RCTs), the use of categorised BMI with inconsistent cut point definitions, and minimal investigation of contemporary combination ICI therapy.

8p vishanshan 27-06-2024 1 1   Download

The study uses a hybrid model, namely C-TAM-TPB. The model combines the Technology Acceptance Model (TAM) and the Planned Behavior Theory (TPB) to investigate factors influencing the behavior of young people toward electric motorbikes.

13p viohoyo 25-04-2024 5 2   Download

The purpose of mergers and acquisitions is to increase the value of the combined company by increasing the synergy effect, as well as improving the competitiveness and efficiency of the company. Within the framework of the study, two hypotheses were put forward: 1) the effectiveness of a merger and acquisition transaction increases with an increase in the capitalization of the company-buyer, 2) the effectiveness of a merger and acquisition transaction increases with an increase in its amount.

6p longtimenosee09 08-04-2024 4 1   Download

The diagnostic rate of Mendelian disorders in sequencing studies continues to increase, along with the pace of novel disease gene discovery. However, variant interpretation in novel genes not currently associated with disease is particularly challenging and strategies combining gene functional evidence with approaches that evaluate the phenotypic similarities between patients and model organisms have proven successful.

20p viellison 28-03-2024 1 1   Download

Ebook "High-performance in-memory genome data analysis: How in-memory database technology accelerates personalized medicine" provide details on innovative approaches to enabling the processing, combination, and analysis of relevant data in real-time. The book bridges the gap between medical experts, such as physicians, clinicians, and biological researchers, and technology experts, such as software developers, database specialists, and statisticians.

239p manmanthanhla0201 26-02-2024 7 1   Download

This study systematically reviewed the RCTs of combined atezolizumab and nab-paclitaxel in the treatment of TNBC and synthesize the evidence-based results on its efectiveness and adverse effects of it.

13p vileonardodavinci 23-12-2023 4 4   Download

There is limited real-world evidence that describes patients with newly diagnosed multiple myeloma (NDMM) treated with the bortezomib, lenalidomide, and dexamethasone (VRd) triplet regimen. We evaluated patient characteristics and treatment outcomes among nontransplanted NDMM patients who received VRd as their first line of therapy (LOT) in US oncology practice settings.

9p vialfrednobel 23-12-2023 9 5   Download

Metastatic castration-resistant prostate cancer (mCRPC) remains a therapeutic challenge and evidence for late-line treatments in real-life is limited. The present study investigates the efficacy and safety of an oral metronomic chemo-hormonal regimen including cyclophosphamide, etoposide, estramustine, ketoconazole and prednisolone (KEES) administered in a consecutive biweekly schedule.

10p vischultz 20-10-2023 5 2   Download

Glioblastoma (GBM) is the most malignant primary tumor in the brain, with poor prognosis and limited effective therapies. Although Bevacizumab (BEV) has shown promise in extending progressionfree survival (PFS) treating GBM, there is no evidence for its ability to prolong overall survival (OS)

23p visharma 20-10-2023 5 2   Download

According to current evidence, the best treatment for fit patients with non-resectable pancreatic cancer (PC) is combination chemotherapy, whereas frail patients are recommended gemcitabine (Gem) monotherapy.

10p visharma 20-10-2023 8 2   Download

Many studies have explored the cost-effectiveness of immunotherapy versus chemotherapy alone. However, there is paucity of evidence on direct pharmacoeconomic studies related to immunotherapy combinations.

10p visharma 20-10-2023 7 2   Download

Although different combinations of nutrition interventions are employed, most are insufficient to reduce stunting significantly. This study aimed to draw current evidence to reduce stunting among under 5 years children from randomized controlled trials. Eligible randomized controlled trials met inclusion criteria were included.

11p viisac 23-09-2023 2 1   Download

The Dempster-Shafer (DS) theory of evidence is frequently used to combine multiple supervised machine learning models into a robust fusion-based model. However, using the DS theory to create a fusion model from multiple one-class classifications (OCCs) for network anomaly detection is a challenging task.

16p vimulcahy 18-09-2023 5 4   Download

The clinical presentations of each patient in this study are different from each other, demonstrating the intrafamilial phenotypic variability of this mutation. Early identification of the underlying genetic course of the disease by sequencing, combined with clinical findings provides solid evidence to diagnosis process, genetic counseling and management strategy.

9p vicaptainmarvel 21-04-2023 4 2   Download

The evaluation and interpretation of forensic DNA mixture evidence faces greater interpretational challenges due to increasingly complex mixture evidence. Such challenges include: casework involving low quantity or degraded evidence leading to allele and locus dropout; allele sharing of contributors leading to allele stacking; and differentiation of PCR stutter artifacts from true alleles.

15p vinarcissa 21-03-2023 5 1   Download

The thesis will attempt to address the following questions: 1. Does the BWS produce superior risk-adjusted returns? 2. Do extreme portfolio trading strategies work in the Australian options market? 3. Can options be combined with equity to generate positive alpha? 4. How can the characteristics of options be used to provide superior returns? 5. Does the rebalancing period matter in the options market? 6. Can equity strategies be extended to the options market?

338p runthenight04 02-02-2023 4 2   Download

In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need to be developed. In this respect, here we reanalyze three metaanalysis data of GWAS in T2D, using the methodology that we have developed to identify disease-associated pathways by combining nominally significant evidence of genetic association with the known biochemical pathways.

33p lyhuyenthu 31-01-2023 9 2   Download

Air pollution will increase the demand and utilisation of Chinese residents’ health services, thereby placing a greater economic burden on the government. This study reveals the spatial impact of socioeconomic, health, policy and population factors combined with environmental factors on government health expenditure.

15p viferrari 28-11-2022 7 3   Download

The study investigates the key factors included knowledge and experience, workload, time pressure and incentives that affect the professional skepticism of independent auditors in Vietnam. The authors have utilized quantitative and qualitative analyses in combination with a logistics regression model and other available analytical tools for conducting the research in SPSS software.

16p visherylsandberg 18-05-2022 8 1   Download

Almost half of the stroke patients admitted to geriatric rehabilitation has persisting problems after discharge. Currently, there is no evidence based geriatric rehabilitation programme available for older stroke patients, combining inpatient rehabilitation with adequate ambulatory aftercare in the community.

11p viisaacnewton 25-04-2022 17 5   Download