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Comet assay
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This pilot investigation has indicated that sub-lethal waterborne Sb(III) exposure manifests in genotoxic effects in freshwater fish species, which may have consequences for resilience and survival. Further study is needed for deeper insight into the relationship between Sb(III) and genotoxicity and the multiple biomarker responses that need assessment to evidence effects.
10p
thebadguys
15-01-2022
8
0
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Individual susceptibility to endogenous and/or exogenous DNA damage depends on DNA repair efficiency and can be evaluated using the comet assay with bleomycin as genotoxic agent. The aim of the study was to evaluate baseline and bleomycin-induced DNA damage and DNA repair capacity in peripheral blood lymphocytes (PBLs) of endometrial cancer (EC) patients considering a family history of cancer.
6p
vilisa271
22-09-2020
15
0
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Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This study analyzed the DNA damage response following ionizing radiation (IR) in 10 GSC lines derived from patients.
13p
vimale2711
25-08-2020
10
2
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The RAD21 cohesin plays, besides its well-recognised role in chromatid cohesion, a role in DNA double strand break (dsb) repair. In Arabidopsis there are three RAD21 paralog genes (AtRAD21.1, AtRAD21.2 and AtRAD21.3), yet only AtRAD21.1 has been shown to be required for DNA dsb damage repair.
14p
viminato2711
22-05-2020
10
1
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The incidence of fungal infections has increased and it is necessary to seek new antifungals that also act against resistant strains. Palmatine is a protoberberine alkaloid noteworthy for its various pharmacological properties, including antifungal properties.
13p
kethamoi4
16-04-2020
12
1
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Oxidative stress is one potential mechanism that explain the direct effects of smoking on cardiac remodeling process. However, no study has compared different myocardial products of macromolecule oxidation after tobacco smoke exposure.
7p
vimax2711
30-03-2020
8
2
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To study the impact of radish oil on the possible genotoxic and hepatotoxic effects of hexavalent chromium, male rats were divided into 4 groups. Group 1 served as control, group 2 received radish oil at the recommended human therapeutic dose (0.07 mL/kg) by gavage, group 3 received sodium dichromate dihydrate (SDD) 520 mg/L in drinking water, and group 4 received both SDD and radish oil as previously mentioned in groups 2 and 3. All treatments were continued for six months.
9p
kequaidan1
16-11-2019
13
1
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The maintenance of plant genome integrity plays a critical function in the processes of DNA replication, transcription, and repair. Short-wave UV radiation (UVC) is among the most harmful agents known to affect genome stability and to induce DNA damage, including double-strand breaks (DSBs).
6p
vikimsa
22-02-2019
24
1
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Beta-carotene and silymarin have antioxidant properties against oxidative damage and are used as dietary supplements. Th e aim of this study was to assess the protective eff ects of β-carotene and silymarin on healthy human lymphocytes exposed to L-arginine-induced oxidative damage.
6p
vivant2711
01-02-2019
11
1
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Nanogenotoxicity is an emergent field, relevant for estimating the potential genotoxic risk of nanomaterials. In this study we investigated the genotoxic potential of zinc oxide (ZnO, ≤35 and 50 nm) and titanium dioxide nanoparticles (NPs) in the nuclei of Allium cepa root meristem cells by using a modified alkaline comet assay.
9p
sony2711
01-02-2019
22
1
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