Complicated malaria

Ebook "Artemisia annua - Pharmacology and biotechnology" is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs.

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Hematological changes are among the most common complications encountered in malaria. This study analyzes and statistically evaluates the hematological changes occur in complicated malaria as compared to uncomplicated malaria. The present study was conducted from January to December 2012 in SCB Medical College, Cutack of Odisha. A total of 120 severe/ complicated malaria patients and 80 uncomplicated malaria patients were investigated.

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Thalassemia is an autosomal recessive disease causing haemolytic anaemia. The ideal treatment of these patients involves regular, 2-4 weekly blood transfusions. The major complications by this treatment are the transmission of transfusion acquired infections such as Hepatitis B virus infection, Hepatitis C virus infection, Human immunodeficiency virus infection, Syphilis, Malaria and transfusion acquired iron overload.

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NTDs contribute to anemia, vomiting, diarrhea, malnutrition and organ damage. Growth and cognitive development are also affected in children, who are highest risk for infection. Contributing to maternal and neonatal mortality, NTDs can complicate pregnancy by causing severe anemia. Recent research indicates that chronic parasitic infections can impair protective immune responses against many unrelated infections (including malaria, TB, and HIV) and can cause impaired responses to vaccines.

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