Conditional deletion
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Disruption of the Neurobeachin gene is a rare genetic mutation that has been implicated in the development of autism and enhanced long-term potentiation of the hippocampal CA1 region, causing a heightened conditioned fear response and impaired fear extinction.
4p vilazada 31-01-2024 4 2 Download
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Accumulation of DNA damage, mutations, and chromosomal abnormalities is associated with aging in many organisms. How directly various forms of genomic instability contribute to lifespan in different aging contexts is still under active investigation.
15p vinarcissa 21-03-2023 5 1 Download
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Copy number variation (CNV) has been implicated in the genetics of multiple human diseases. Spinal muscular atrophy (SMA) and 22q11.2 deletion syndrome (22q11.2DS) are two of the most common diseases which are caused by DNA copy number variations. Genetic diagnostics for these conditions would be enhanced by more accurate and efficient methods to detect the relevant CNVs.
7p vibeauty 23-10-2021 16 0 Download
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Subchondral bone (SCB) thickening is one of the earliest detectable changes in osteoarthritic joints and is considered a potential trigger for subsequent articular cartilage degeneration. In this manuscript, we examine whether disruption to the SCB osteocyte network contributes to the initiation and pathogenesis of osteoarthritis.
11p vivermont2711 28-01-2021 19 2 Download
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Conditional deletion of the tumour suppressor gene Apc within the murine intestine results in acute Wnt signalling activation. The associated over-expression of a myriad of Wnt signalling target genes yields phenotypic alterations that encompass many of the hallmarks of neoplasia.
9p vialabama2711 21-09-2020 6 0 Download
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The X-linked condition “Aarskog-Scott syndrome (AAS)” causes a characteristic combination of short stature, facial, genital and skeletal anomalies. Studies elucidated a causative link between AAS and mutations in the FGD1 gene, which encodes a Rho/Rac guanine exchange factor.
6p videshiki2711 19-02-2020 9 1 Download
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Cold environmental conditions influence the growth and development of plants, causing crop reduction or even plant death. Under stress conditions, cold-inducible promoters regulate cold-related gene expression as a molecular switch.
11p nutifooddau 27-01-2019 18 2 Download
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Natural language parsing is conceived to be a procedure of disambiguation, which successively reduces an initially totally ambiguous structural representation towards a single interpretation. Graded constraints are used as means to express wellformedness conditions of different strength and to decide which partial structures are locally least preferred and, hence, can be deleted. This approach facilitates a higher degree of robustness of the analysis, allows to introduce resource adaptivity into the parsing procedure, and exhibits a high potential for parallelization of the computation. ...
5p bunrieu_1 18-04-2013 47 3 Download
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Protein family databases obtain sequences fromone of the large protein sequence databases,most commonly SWISS- PROT with TrEMBL (Bairoch and Apweiler, 2000) but also PIR (Barker et al., 2000). They then apply an algorithm, either manual or automatic, to group the sequences into families. Each family is represented in one or more ways to facilitate both inspection by humans and comparison by computer programs. The most common representation is a multiple alignment of the family’s sequences, either with insertion and deletion (gap) characters or without.
12p yasuyidol 02-04-2013 46 6 Download
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The preparation of human karyotype for the first time in 1959 led to the identification of numerical aberrations in the following years associated with Down’s, Turner and Klinefelter syndromes which implied the need for routine screening for chromosomal anomalies in certain clinical conditions.
512p conquynho32 15-09-2012 62 8 Download
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In summary, the DLEU2/miR-15a/16-1 tumor suppressor locus plays a role in regulating the expansion of the mature B-cell pool, by preventing the entry into G0/G1-S transition. The impairment of this cell cycle control in MDR-deleted cells may allow them to proliferate after BCR stimulation by foreign or self antigens. In these conditions, a model for the pathogenesis of CLL with 13q14 deletion based on the presumptive cellular origin of the tumor cell precursor can be proposed.
412p wawawawawa 26-07-2012 46 5 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A simplified in vitro ligation approach to clone an E1B55k-deleted double-targeted conditionally-replicative adenovirus Yosef S Haviv
9p dauphong5 25-12-2011 46 2 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Model-driven analysis of experimentally determined growth phenotypes for 465 yeast gene deletion mutants under 16 different conditions...
0p thulanh20 12-11-2011 34 1 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Conditional deletion of epithelial IKKbeta impairs alveolar formation through apoptosis and decreased VEGF expression during early mouse lung morphogenesis...
43p toshiba11 20-10-2011 48 4 Download
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The terms of this Addendum apply to the Licensee’s license of Oracle Corporation products (“Oracle Programs”) under the Agreement. All terms and conditions of the Agreement that are not expressly modified, supplemented, or deleted herein shall remain in force, and shall apply to all matters contained herein. Any defined terms in the Agreement shall have the same meanings when used herein, unless expressly modified herein.
2p bichhuyen 19-06-2009 109 5 Download