Controlling lipid oxidation

Specific lipids of the purple membrane ofHalobacteriaare required for normal bacteriorhodopsin structure, function, and photocycle kinetics [Hendler, R.W. & Dracheva, S. (2001) Biochemistry (Moscow)66, 1623–1627]. The decay of the M-fast intermediate through a path including the O intermediate requires the presence of a hydrophobic envi-ronment near four charged aspartic acid residues within the cytoplasmic loop region of the protein (R. W. Hendler & S. Bose, unpublished results).

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The role of oxidative stress in pilocarpine-induced status epilepticus was investigated by measuring lipid peroxidation level, nitrite content, GSH con-centration, and superoxide dismutase and catalase activities in the hippo-campus of Wistar rats. The control group was subcutaneously injected with 0.9% saline. The experimental group received pilocarpine (400 mgÆkg )1 , subcutaneous). Both groups were killed 24 h after treatment.

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Lipid accumulation alters macrophage biology and contributes to lipid retention within the vessel wall. In this study, we investigated the role of adipophilin on triglyceride accumulation and lipid-droplet formation in THP-1-derived macrophages (THP-1 macrophages). In the presence of acetylated low-density lipoprotein, macrophages infected with an adeno-virus expressing human adipophilin showed a 31% increase in triglyceride content and a greater number of lipid droplets compared with control cells....

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