Cox proportional hazard regression

Part 2 of ebook "Regression modeling strategies: With applications to linear models, logistic and ordinal regression, and survival analysis (Second edition)" provides readers with contents including: Chapter 15 - Regression models for continuous Y and case study in ordinal regression; Chapter 16 - Transform-both-sides regression; Chapter 17 - Introduction to survival analysis; Chapter 18 - Parametric survival models; Chapter 19 - Case study in parametric survival modeling and model approximation; Chapter 20 - Cox proportional hazards regression model; Chapter 21 - Case study in cox regressi...

301p daonhiennhien 03-07-2024 2 1   Download

No previous prospective research has explored the association of the TyG (fasting triglyceride-glucose) index and TG/HDL-C ratio as insulin resistance markers with the risk of colorectal cancer (CRC) incidence in the Northern Chinese population.

11p vialfrednobel 23-12-2023 5 4   Download

The TROIKA trial established that HD201 and trastuzumab were equivalent in terms of primary end-points (total pathological complete response) following neoadjuvant treatment. The objective of the present analysis was to compare survival outcomes and final safety.

9p vischultz 20-10-2023 1 1   Download

Recurrence and metastases are still frequent outcomes after initial tumour control in women diagnosed with breast cancer. Although therapies are selected based on tumour characteristics measured at baseline, prognostic biomarkers can identify those at risk of poor outcomes.

9p vischultz 20-10-2023 4 1   Download

Visceral adiposity index (VAI) and a body shape index (ABSI) were newly developed indices for visceral fat mass. Whether they are superior to conventional obesity indices in predicting colorectal cancer (CRC) remains unclear.

10p vischultz 20-10-2023 2 1   Download

Cox-regression-based methods have been commonly used for the analyses of survival outcomes, such as age-at-disease-onset. These methods generally assume the hazard functions are proportional among various risk groups. However, such an assumption may not be valid in genetic association studies, especially when complex interactions are involved. In addition, genetic association studies commonly adopt case-control designs.

11p vinarcissa 21-03-2023 5 1   Download

We collected information on patients with rectal adenocarcinoma in the United States from the Surveillance, Epidemiology, and EndResults (SEER) database. We used this information to establish a model that combined deep learning with a multilayer neural network (the DeepSurv model) for predicting the survival rate of patients with rectal adenocarcinoma.

14p vipriyankagandhi 27-07-2022 7 2   Download

Although pancreatic ductal adenocarcinoma (PDAC) rarely metastasizes to the skeleton, disseminated tumor cells have been detected in bone marrow samples from patients with this disease. The prognostic value of such findings is currently unclear. Thus, the current study aimed to clarify the prognostic information associated with disseminated tumor cell detection in samples from patients with PDAC.

11p visusanwojcicki 28-06-2022 8 2   Download

The role of elevated pre-diagnostic C-reactive protein (CRP) concentrations on mortality in individuals with colorectal cancer (CRC) remains unclear. Methods: We investigated the association between pre-diagnostic high-sensitivity CRP concentrations and CRP genetic variation associated with circulating CRP and CRC-specific and all-cause mortality based on data from 1,235 individuals with CRC within the European Prospective Investigation into Cancer and Nutrition cohort using multivariable-adjusted Cox proportional hazards regression.

13p visusanwojcicki 28-06-2022 8 2   Download

Diabetes mellitus (DM) is a well-known risk factor for tuberculosis (TB). Metformin, which is an essential anti-diabetic drug, has been shown to exhibit anti-TB efects in patients with DM. Its effect on preventing the development of TB among patients who are newly diagnosed with DM remains unclear.

11p vimackenziebezos 29-11-2021 5 1   Download

There is evidence that long non-coding RNA (lncRNA) is related to genetic stability. However, the complex biological functions of these lncRNAs are unclear. Multivariate Cox proportional hazard regression analysis was applied to conduct lncRNA prognosis model.

13p vimahuateng 26-11-2021 3 0   Download

The evidence base to inform the decision making process in patients with early stage oral cancer and a clinical and radiological N0 neck remains insufficient to answer the question when it is safe to “watch and wait” and when to proceed with a selective neck dissection.

6p virose2711 24-09-2020 16 0   Download

This study aimed to develop a nomogram that predicts the overall survival (OS) of rectal neuroendocrine tumours (NETs). Methods: We retrospectively analysed 310 patients with rectal neuroendocrine tumours in 5 hospitals in southern China. All of the patients were assigned to the training set.

7p viamsterdam 18-09-2020 11 0   Download

Kallikreins have clinical value as prognostic markers in a subset of malignancies examined to date, including kallikrein 3 (prostate specific antigen) in prostate cancer. We previously demonstrated that kallikrein 6 is expressed at higher levels in grade IV compared to grade III astrocytoma and is associated with reduced survival of GBM patients.

9p viamsterdam 18-09-2020 12 0   Download

The main aim of this study was to investigate pre- and post-diagnostic physical activity (PA) levels, as well as changes in pre- and post-diagnostic PA levels, and their association with all-cause and breast cancer-specific mortality in women with breast cancer.

10p vimoscow2711 29-08-2020 12 0   Download

Prognosis is poor for patients with malignant progression such as distant metastasis of oral squamous cell carcinoma (OSCC). Evidence indicates that miR-448 promotes the proliferation and inhibits apoptosis of OSCC cells. Therefore, we aimed to investigate the function of miR-448 to predict tumor progression and prognosis of OSCC.

6p vimale2711 21-08-2020 11 2   Download

Colorectal cancer (CRC) is a major killer. Host immunity is important in tumorigenesis. Direct comparison among IL-36α, IL-36β and IL-36γ in the prognosis of CRC is unclear.

12p vikuala271 13-06-2020 15 2   Download

Globally, epidemiological evidence suggests cancer incidence and outcomes among Indigenous peoples are a growing concern. Although historically cancer among First Nations (FN) peoples in Canada was relatively unknown, recent epidemiological evidence reveals a widening of cancer related disparities.

10p vikuala271 13-06-2020 8 1   Download