Current chemotherapeutic
-
Intrahepatic cholangiocarcinoma (CCA) is amongst the most common primary liver tumors worldwide. CCA carries a bad prognosis prompting research to establish new treatment modalities other than surgery and the current chemotherapeutic regimens adopted.
11p vileonardodavinci 23-12-2023 4 2 Download
-
The failure of current chemotherapeutic agents for pancreatic cancer (PCa) makes it the most aggressive soft tissue tumor with a 5-year survival of slightly above 10% and is estimated to be the second leading cause of cancer death by 2030.
16p vileonardodavinci 23-12-2023 4 2 Download
-
Midostaurin combined with chemotherapy is currently used to treat newly diagnosed acute myeloid leukemia (AML) patients with FMS-like tyrosine kinase 3 (FLT3)-mutations. However, midostaurin acts as an antagonist to some chemotherapeutic agents in leukemia cell lines without FLT3 mutations.
14p vikolindagrabar 27-07-2022 4 2 Download
-
Hypopharyngeal cancer is a relatively rare malignancy with poor prognosis. Current chemotherapeutic algorithm is still far from personalized medicine, and the identification of the truly active therapeutic biomarkers and/ or targets is eagerly awaited.
16p vikolindagrabar 27-07-2022 1 1 Download
-
The aminoisoquinoline FX-9 shows pro-apoptotic and antimitotic effects against lymphoblastic leukemia cells and prostate adenocarcinoma cells. In contrast, decreased cytotoxic effects against non-neoplastic blood cells, chondrocytes, and fibroblasts were observed. However, the actual FX-9 molecular mode of action is currently not fully understood.
11p vimahuateng 26-11-2021 11 1 Download
-
Activation of autophagy flux contributed to resistance of breast cancer (BC) cells to current chemotherapeutic drugs, which seriously limited their therapeutic efficacy and facilitated BC recurrence in clinic. However, the detailed mechanisms are still not fully understood.
10p vianrose2711 27-04-2021 12 1 Download
-
Breast cancer is a major health problem that threatens the lives of millions of women worldwide each year. Most of the chemotherapeutic agents that are currently used to treat this complex disease are highly toxic with long-term side effects.
10p vijennie2711 25-09-2020 16 1 Download
-
Chk1 inhibitors are currently in clinical trials in combination with a range of cytotoxic agents and have the potential to potentiate the clinical activity of a large number of standard of care chemotherapeutic agents.
13p virose2711 22-09-2020 12 2 Download
-
Hepatocellular carcinoma (HCC) is a major cause of cancer deaths worldwide. However, current chemotherapeutic drugs for HCC are either poorly effective or expensive, and treatment with these drugs has not led to satisfactory outcomes.
13p vialabama2711 21-09-2020 10 1 Download
-
Pancreatic cancer, one of the most dreadful gastrointestinal tract malignancies, with the current chemotherapeutic drugs has posed a major impediment owing to poor prognosis and chemo-resistance thereby suggesting critical need for additional drugs as therapeutics in combating the situation.
15p viamsterdam 18-09-2020 10 1 Download
-
Although the efficacy of bevacizumab has been established in patients with metastatic colorectal cancer (mCRC), population-based studies are needed to gain insight into the actual implementation of bevacizumab in daily practice. Since these studies are lacking for patients with metachronous metastases, the aim of this study is to evaluate the current role of bevacizumab in the treatment of metachronous metastases of CRC.
9p vinaypyidaw2711 26-08-2020 9 1 Download
-
Gemcitabine is currently the standard chemotherapy for the adjuvant treatment of pancreatic cancer. This chemotherapeutic agent is generally well-tolerated, myelosuppression and gastrointestinal toxicity being common side effects. Nevertheless, gemcitabine-induced pulmonary toxicity has been rarely reported.
5p vimale2711 25-08-2020 9 1 Download
-
Colorectal cancer is the second most common cause of cancer deaths for both men and women, and the third most common cause of cancer in the U.S. Toxicity of current chemotherapeutic agents for colorectal cancer, and emergence of drug resistance underscore the need to develop new, potentially less toxic alternatives.
10p vimale2711 25-08-2020 7 1 Download
-
The currently approved therapies fail in a substantial number of colorectal cancer (CRC) patients due to the molecular heterogeneity of CRC, hence new efficient drug combinations are urgently needed. Emerging data indicate that 5-azanucleosides are able to sensitize cancer cells to the standard chemotherapeutic agents and contribute to overcoming intrinsic or acquired chemoresistance.
13p vimale2711 25-08-2020 9 2 Download
-
Eribulin mesylate is currently indicated as a sequential monotherapy to be administered after two chemotherapeutic regimens, including anthracycline and taxane treatments, for treatment of metastatic breast cancer.
7p vibaku2711 22-07-2020 8 2 Download
-
Glioblastoma multiforme (GBM) is the most malignant central nervous system tumor. Alkylating agent, temozolomide (TMZ), is currently the first-line chemotherapeutic agent for GBM. However, the sensitivity of GBM cells to TMZ is affected by many factors.
10p viputrajaya2711 22-06-2020 15 0 Download
-
Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and survival.
10p vikuala271 13-06-2020 9 1 Download
-
The current production of rubber is 2.87 million tonnes per year and export is 2.57 million tonnes per year. The remnants are domestically used. The important trading partners of Thailand are China, Japan, Malaysia and USA. The rubber price during 1999-2003 gradually decreased from 1998 until 2000. The government had to interfere in the mid-2000. However, the rubber price has been increasing since the end of 2000 due to the world demand and expansion of world economy. The rubber plantation industry is dominated by the small holding sector accounting for 95% in terms of area.
108p thieubaotrang 23-04-2013 57 5 Download
-
The share of infrastructure increased to 40 percent in 2011 from 31 percent in 2010 while the share of industry decreased to 32 percent––though given the substantial increase in BNDES lending, the absolute levels of credit for industry have increased. (see Figure 19). Looking further ahead, BNDES could gradually shift toward promoting the development of long-term capital markets, including by playing a role in standardization and market making (e.g., co-financing of infrastructure projects with the private sectors) in the long-term financing market. ...
21p hongphuocidol 04-04-2013 51 8 Download
-
The Government of India has highlighted the need for a holistic approach in dealing with the impact of extremism on communities, in line with the recommendations of an Expert Group on Development Challenges in Extremist Affected Areas submitted to the Planning Commission in 2008.
44p nhamnhiqa 01-03-2013 45 2 Download