Current reporting activity

1-Hydroxyphenazine (HP) is a heterocyclic nitrogenous compound which reported various potential bioactivities. The current work aimed to utilize soybean residue by-product (SRBP) as a C/N source for the biosynthesis of HP via fermentation and investigated its potent inhibition against some plant pathogen fungi.

7p viengfa 28-10-2024 3 1   Download

Alpinia vietnamica H.Ð. Tran, Luu & Skornick was identified as a new species in 2019, which is widely distributed in Thua Thien Hue, Quang Nam, and Kon Tum provinces, Vietnam. The current study wishes to report phytochemical investigation, and the biological activities (cytotoxic, antioxidative, and α-glucosidase inhibitory) of isolated compounds.

5p dianmotminh02 03-05-2024 12 2   Download

AR-42, a new orally bioavailable, potent, hydroxamate-tethered phenylbutyrate class I/IIB histone deacetylase inhibitor currently is under evaluation in phase 1 and 2 clinical trials and has demonstrated activity in both hematologic and solid tumor malignancies. This report focuses on the preclinical characterization of the pharmacokinetics of AR-42 in mice and rats.

9p caothientrangnguyen 09-05-2020 18 3   Download

Thesis with the task on the basis of studying the theoretical and practical issues of the quality of rapporteur activities, proposing directions and solutions to improve the quality of reporters' activities in the Mekong Delta. To grasp the details of the research content, please join the article.

29p lequangvinh1608 13-08-2019 24 3   Download

Laboratoire des Venins et Toxines, Institut Pasteur de Tunis, Tunisia; 2De´partement d’Inge´nierie et d’Etude des Prote´ines, CEA, Saclay, France; 3UMR 6560, Universite´ de la Me´diterrane´e, CNRS, Inge´nierie des Prote´ines, Laboratoire de Biochimie, IFR Jean-Roche, Faculte´ de Me´decine Nord, Marseille, France; 4Laboratoire de Neurophysiologie UPRES EA 2647, UFR Sciences, Angers, France BotXIV and LqhaIT are two structurally related long chain scorpion a-toxins that inhibit sodium current inactivation in excitable cells.

11p system191 01-06-2013 46 4   Download

Protein refolding is currently a fundamental problem in biophysics and molecular biology. We have studied the refolding process of frutalin, a tetrameric lectin that presents structural homology with jacalin but shows a more marked biological activity. The initial state in our refolding puzzle was that proteins were unfolded after thermal denaturation or denaturation induced by guanidine hydrochloride, and under both conditions, frutalin was refolded.

6p research12 01-06-2013 42 4   Download

The protein-modifying agent arsenite stimulates glucose uptake in 3T3-L1 adipocytes. In the current study we have analysed the signalling pathways that contribute to this response. By subcellular fractionation we observed that arsenite, like insulin, induces translocation of the GLUT1 and GLUT4 glucose transporters from the low-density membrane fraction to the plasma membrane. Arsenite did not activate early steps of the insulin receptor (IR)-signalling pathway and the response was insensitive to inhibition of phosphatidylinositol-3¢-kinase (PI-3¢)kinaseby wortman-nin. ...

13p tumor12 20-04-2013 36 3   Download

The currently accepted model of moult control in crusta-ceans relies entirely on the hypothesis that moult-inhibiting hormone (MIH) and crustacean hyperglycaemic hormone (CHH) repress ecdysteroid synthesis of the target tissue (Y-organ) only during intermoult, and that changes in syn-thesis and/or release of these neurohormones are central to moult control.

9p tumor12 20-04-2013 51 3   Download

Most of the examples of protein translocation across a membrane (such as the import of classical secretory proteins into the endoplasmic reticulum, import of proteins into mitochondria and peroxisomes, as well as protein import into and export from the nucleus), are understood in great detail.

11p fptmusic 16-04-2013 39 4   Download

HIV-1 protease is an important target for treatment of AIDS, and efficient drugs have been developed. However, the resistance and negative side effects of the current drugs has necessitated the development of new compounds with different binding patterns. In this study, nine C-terminally duplicated HIV-1 protease inhibitors were cocrystallised with the enzyme, the crystal structures analysed at 1.8–2.3 A˚ resolution, and the inhibitory activity of the compounds characterized inorder toevaluate the effects of the individual modifications. ...

13p fptmusic 16-04-2013 44 3   Download

The currently applied reaction structure in stoichiometric flux balance mod-els for the nonoxidative branch of the pentose phosphate pathway is not in accordance with the established ping-pong kinetic mechanism of the enzymes transketolase (EC 2.2.1.1) and transaldolase (EC 2.2.1.2). Based upon the ping-pong mechanism, the traditional reactions of the nonoxida-tive branch of the pentose phosphate pathway are replaced by metabolite specific, reversible, glycolaldehyde moiety (C2 ) and dihydroxyacetone moi-ety (C3) fragments producing and consuming half-reactions. ...

13p fptmusic 12-04-2013 41 3   Download

In humans, thromboxane (TX) A2 signals through two receptor isoforms, thromboxane receptor (TP)aand TPb, which are transcriptionally regula-ted by distinct promoters, Prm1 and Prm3, respectively, within the single TP gene. The aim of the current study was to investigate the ability of the endogenous peroxisome proliferator-activated receptor (PPAR)c ligand 15-deoxy-D 12,14 -prostaglandin J2 (15d-PGJ2) to regulate expression of the human TP gene and to ascertain its potential effects on the individual TPa and TPbisoforms....

20p fptmusic 12-04-2013 37 3   Download

The budding yeastSaccharomyces cerevisiaepossesses a very flexible and complex programme of gene expression when exposed to a plethora of environmental insults. Therefore, yeast cell homeostasis control is achieved through a highly coordinated mechanism of transcription regulation invol-ving several factors, each performing specific functions. Here, we present our current knowledge of the function of the yeast activator protein family, formed by eight basic-leucine zipper trans-activators, which have been shown to play an important role in stress response....

0p awards 06-04-2013 51 2   Download

High-resolution X-ray diffraction structures of integral membrane proteins have revealed various binding modes of lipids, but current spectroscopic studies still use uniform macroscopic binding constants to describe lipid binding. The Adair approach employing microscopic lipid-binding con-stants has previously been taken to explain the enhancement of agonist binding to the nicotinic acetylcholine receptor by general anaesthetics in terms of the competitive displacement of essential lipid activator molecules [Walcher S, Altschuh J & Sandermann H (2001) J. Biol. Chem. 276, 42191–42195]....

8p awards 06-04-2013 56 2   Download

The TPaand TPbisoforms of the human thromboxane A2 receptor (TP) arise by differential splicing but are under the transcriptional control of two distinct promoters, termed Prm1 and Prm3, respectively (Coyle et al. 2002Eur J Biochem269, 4058–4073). The aim of the current study was to determine the key factors regulating TPbexpression by functionally charac-terizing Prm3, identifying the core promoter and the cis-acting elements regulating basal Prm3 activity.

18p awards 05-04-2013 40 3   Download

The biological ion channel gramicidin A (gA) was modified by synthetic means to obtain the tail-to-tail linked asymmetric gA-derived dimer com-pound3. Single-channel current measurements for 3in planar lipid bilayers exhibit an Eisenman I ion selectivity for alkali cations. The structural asymmetry does not lead to an observable functional asymmetry. The structure of 3in solution without and with Cs cations was investigated by 1 H-NMR spectroscopy. In CDCl3 ⁄CD3OH (1 : 1, v⁄v),3forms a mixture of double-strandedb-helices....

12p awards 05-04-2013 31 3   Download

HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such,HIV-1proteasehasbecomean important target for the treatment ofAIDS, and efficient drugs have beendeveloped. However, negative side effects and fast emerging resistance to the current drugs have necessitated the development of novel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....

9p awards 05-04-2013 32 2   Download

Protein disulfide oxidoreductases are ubiquitous redox enzymes that catalyse dithiol–disulfide exchange reactions with a CXXC sequence motif at their active site. Adisulfide oxidoreductase, a highly thermostable protein, was isolated from Pyrococcus furiosus(PfPDO), which is characterized by two redox sites (CXXC) and an unusual molecularmass. Its 3D structure at high resolution suggests that it may be related to the multidomain protein disulfide-isomerase (PDI), which is currently known only in eukaryotes....

12p dell39 03-04-2013 35 3   Download

Group I intron ribozymes require cations for folding and catalysis, and the current literature indicates that a number of cations can promote folding, but only Mg 2+ and Mn 2+ support both processes. However, some group I introns are active only with Mg 2+ , e.g. three of the five group I introns in Chlamydomonas reinhardtii. We have investigated one of these ribozymes, an intron from the 23S LSU rRNA gene of Chlamydomonas reinhardtii (Cr.LSU), by determining if the inhibition by Mn 2+ involves catalysis, folding, or both....

14p inspiron33 26-03-2013 46 3   Download

In the first half of the talk, the current state of our ongoing structure-function analysis of the mRNA transcription cycle will be dis-cussed. The crystallographic structures of the complete 12-subunit RNA polymerase II in free form and with bound DNA and RNA have been determined as atomic models. The structure of the complete Pol II elongation complex bound by the transcript cleavage factor TFIIS explained how Pol II uses a single tunable active site for both RNA synthesis and RNA cleavage.

12p galaxyss3 19-03-2013 43 4   Download