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Deubiquitinating enzymes
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Lymphoma represents a heterogeneous group of cancers affecting the lymphatic system, encompassing nonHodgkin lymphoma (NHL) and Hodgkin lymphoma (HL). The majority of NHL cases originate from B cells. HL is characterized by the presence of rare Hodgkin and Reed-Sternberg cells. Within the context of the inflammatory response, two SH2 domain-containing protein tyrosine phosphatases (SHPs), namely SHP-1 and SHP-2, serve as negative regulators.
6p
viellison
28-03-2024
2
2
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The deubiquitinating (DUB) enzyme ubiquitin-specific protease 18 (USP18), also known as UBP43, is an ubiquitin-specific protease linked to several human malignancies. However, USP18’s underlying function in human cervical cancer remains unclear.
9p
vimale2711
21-08-2020
9
0
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P53 pathway inactivation plays an important role in the process of breast cancer tumorigenesis. Posttranslational protein modification abnormalities have been confirmed to be an important mechanism underlying inactivation of p53.
14p
vimanila2711
25-06-2020
8
0
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Microbial pathogens exploit the ubiquitin system to facilitate infection and manipulate the immune responses of the host. In this study, susceptibility to Yersinia enterocolitica and Yersinia pseudotuberculosis invasion was found to be increased upon overexpression of the deubiquitinating enzyme otubain 1 (OTUB1), a member of the ovarian tumour domain-containing protein family.
16p
mobifone23
21-01-2013
41
3
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Ubiquitin carboxy-terminal hydrolase L5 (UCHL5) is a proteasome-associ-ated deubiquitinating enzyme, which, along with RPN11 and USP14, is known to carry out deubiquitination on proteasome. As a member of the ubiquitin carboxy-terminal hydrolase (UCH) family, UCHL5 is unusual because, unlike UCHL1 and UCHL3, it can process polyubiquitin chain.
10p
cosis54
08-12-2012
34
2
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Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer...
10p
thulanh8
06-10-2011
45
2
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