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Differential targeting
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Breast cancer remains a significant health challenge worldwide, necessitating the identification of reliable biomarkers for early detection, accurate prognosis, and targeted therapy.
13p
vikoch
27-06-2024
1
1
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Immunotherapy targeting PD-1/PD-L1 has revolutionized the treatment of extensive-stage small cell lung cancer (ES-SCLC). However, clinical trials suggest differential efficacy of anti-PD-1 agents and anti-PD-L1 agents in first-line treatment of ES-SCLC. This retrospective multicenter study aimed to compare the efficacy and safety of anti-PD-1 agents versus anti-PD-L1 agents in first-line treatment of ES-SCLC in real-world practice.
12p
vikoch
27-06-2024
1
1
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Strategic positioning is the assertion of an organizations personality on decisions of how and where to compete, it determines competitive position in the market place and differentiates the offering to the market. Operational positioning is an exercise in communication that concentrates on perception and image that complements the role of strategic positioning. This book offers an alternative to the traditional process of segmentation, targeting and positioning, highlighting some important implications for management and marketing practitioners as well as academics.
285p
vimeyers
29-05-2024
3
2
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Based on the selected target segment, positioning was carried out based on three points of differentiation: the result for everyone, the simplicity and uniqueness of the methodology and the learning speed. Final positioning concept is formulated in the paper.
9p
longtimenosee10
26-04-2024
3
1
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The current research examines the relationship of the Entrepreneurial supply chain dimensions (proactive approach, innovation, risk management and customer focus) with the supply chain strategies (undifferentiated marketing strategy, concentrated marketing strategy and differentiated marketing strategy). The focus of this investigation is to explore the role of adoption of entrepreneurial supply chains in the identification and selection of the appropriate strategy for the target market in the context of general company foe batteries manufacturing.
11p
longtimenosee09
08-04-2024
5
0
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Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermethylation in HPV(+) oropharyngeal cancers, but only few consistent target genes have been so far described, and the evidence of a functional impact on gene expression is still limited.
12p
vioraclene
31-03-2024
3
1
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Part 1 book "Veterinary bacteriology" includes content: Clinical mastitis in ewes - bacteriology, epidemiology and clinical features; brucellosis in mammals of costa rica - an epidemiological survey; bacterial species associated with interdigital phlegmon outbreaks in finnish dairy herds; direct detection and differentiation of pathogenic leptospira species using a multi gene targeted real time pcr approach; prevalence of bacterial genotypes and outcome of bovine clinical mastitis due to streptococcus dysgalactiae and streptococcus uberis;... and other contents.
218p
muasambanhan03
02-01-2024
3
2
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KRAS-mutated non-small cell lung cancer (NSCLC) accounts for 23–35% and 13–20% of all NSCLCs in white patients and East Asians, respectively, and is therefore regarded as a major therapeutic target. However, its epidemiology and clinical characteristics have not been fully elucidated because of its wide variety of mutational subtypes.
9p
vileonardodavinci
23-12-2023
5
2
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The incidence of primary liver tumors, hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma (ICC), and combined HCC/ICC (cHCC/CC) is increasing. For ICC, targeted therapy exists only for a small subpopulation of patients, while for HCC, Sorafenib and Lenvatinib are in use.
11p
vileonardodavinci
23-12-2023
5
2
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To review our long-term clinical experience, analyze the failure patterns, and give suggestions for target volume delineation of carcinoma showing thymus-like differentiation (CASTLE) treated with intensity-modulated radiotherapy (IMRT).
8p
vileonardodavinci
23-12-2023
5
3
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Programmed Cell Death-1/ Programmed Death-ligand 1 (PD-1 / PD-L1) inhibitor therapies targeting immunocytes induce persistent tumor remission in various cancers. However, the appropriate biomarkers for the therapeutic efficacy of PD-L1 and PD-1 blockade remain elusive.
13p
vischultz
20-10-2023
3
1
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Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC development and progression is not well understood. Methods We sought to establish a dynamic Chinese hamster OSCC animal model, construct miRNA differential expression profiles of its occurrence and development, predict its targets, and perform functional analysis and validation in vitro.
19p
vischultz
20-10-2023
6
2
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Hepatocellular carcinoma (HCC) is common worldwide, and novel therapeutic targets and biomarkers are needed to improve outcomes. In this study, bioinformatics analyses combined with in vitro and in vivo assays were used to identify the potential therapeutic targets. Differentially expressed genes (DEG) in HCC were identified by the intersection between The Cancer Genome Atlas and International Cancer Genome Consortium data.
15p
vioracle
29-09-2023
7
2
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Continued part 1, part 2 of ebook "Building great customer experiences" provides readers with contents including: people a key differentiator; the massive impact of leadership and culture on the customer experience; the customer experience is the embodiment of the brand; managing your customer experience, the Customer Experience Pyramid™; measuring your customer experience; targeting driving behaviours that impact your customer experience;...
126p
lytamnguyet
04-08-2023
8
6
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Researchers have been exploring the molecular mechanisms underlying the control of periodontal ligament stem cell (PDLSC) osteogenic differentiation. Recently, long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) were shown to function as competitive endogenous RNAs (ceRNAs) to regulate the effect of microRNAs (miRNAs) on their target genes during cell differentiation.
13p
vinarcissa
21-03-2023
2
1
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Genomic prediction of agronomic traits as targets for selection in plant breeding programmes is increasingly common. The methods employed can also be applied to predict traits from other sources of covariates, such as metabolomics.
7p
vinarcissa
21-03-2023
1
1
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Genome-wide scans for regions that demonstrate deviating patterns of genetic variation have become common approaches for finding genes targeted by selection. Several genomic patterns have been utilized for this purpose, including deviations in haplotype homozygosity, frequency spectra and genetic differentiation between populations.
14p
vinarcissa
21-03-2023
3
1
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This study aims to compare microRNA expression levels in wt and Bag-1 knockout (KO) MCF-7 breast cancer cells. hsa-miR-429 was selected as a potential miRNA in BAG-1KO MCF-7 cells because of the downregulation both in bioinformatics and validation qRT-PCR assay. According to predicted mRNA targets and functional enrichment analysis the ten hub proteins that are phosphatidylinositol4,5-biphosphate 3-kinase catalytic subunit alpha (PIK3CA), kinase insert domain receptor (KDR), GRB2 associated binding protein 1 (GAB1).
30p
lyhuyenthu
31-01-2023
2
2
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Apogamy is a unique asexual reproduction in the ferns, in which somatic cells of gametophytes go through dedifferentiation and then differentiate into haploid sporophytes bypassing fertilization. Restricted to the lack of genomic information, molecular mechanisms of apogamy have remained unclear.
14p
vihagrid
30-01-2023
8
3
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Lecture Introduction to Business: Lesson 24. The main topics covered in this lesson include: marketing mix, market segmentation, market targeting, marketing communication, geographic basis, demographic basis, psychographic basis, product differentiation,...
6p
alucardhellsing
30-04-2022
20
1
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