DNA region sequences
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Cancer mutations accumulate through replication errors and DNA damage coupled with incomplete repair. Individual mutational processes often show nucleotide sequence and functional region preferences. As a result, some sequence contexts mutate at much higher rates than others, with additional variation found between functional regions.
19p vicwell 29-02-2024 2 1 Download
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The fine-scale cell-free DNA fragmentation patterns in early-stage cancers are poorly understood. We developed a de novo approach to characterize the cell-free DNA fragmentation hotspots from plasma whole-genome sequencing.
15p vicwell 29-02-2024 2 1 Download
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Ebook "Species diversity and community structure: Novel patterns and processes in plants, insects, and fungi" introduces recent progress in the study of species diversity and community structures in terrestrial organisms conducted by three groups at Kyoto University. First, it explains species diversity and the functioning of fungi in Asian regions as outlined by metagenomic approaches using next-generation sequencing technology. The advances in high-throughput sequencing technologies accelerate the speed of species inventorying, especially for microorganisms.
70p manmanthanhla0201 26-02-2024 2 1 Download
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Tumour mutation burden (TMB), defined as the number of somatic mutations per megabase within the sequenced region in the tumour sample, has been used as a biomarker for predicting response to immune therapy.
9p vileonardodavinci 23-12-2023 5 4 Download
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The study using molecular data from three DNA regions (matK, rbcL, and trnH-psbA) supported the monophyly of Melodinus. The M. cochinchinensis from Vietnam and China are closely related. There are some genetic variations in the sequences of Melodinus cochinchinensis from Belgium versus Asiatic M. cochinchinensis, as well as the phylogenetic position of the species, suggesting the possibility of misidentification of M. cochinchinensis from Belgium.
7p giangnhanly 02-10-2023 8 3 Download
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The use of DNA barcodes is a molecular method commonly used for the identification of specimens that are difficult to pinpoint accurately by traditional morphological methods. DNA barcoding uses standard short genomic regions that are universally present in target lineages and has sufficient sequence variation to identify species in the genus.
9p vicaptainmarvel 21-04-2023 4 2 Download
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In this study, we sequenced the chloroplast gene region (matK) to identify the genetic characteristics of T. chantrieri and their phylogenetic inference in the genus Tacca in Ba Vi National Park (Ba Vi NP). This study contributes to developing a DNA barcode database as a foundation for conservation, evolution, and biological systems.
11p viblackwidow 07-04-2023 11 3 Download
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Chloroplast DNA is a primary source of molecular variations for phylogenetic analysis of photosynthetic eukaryotes. However, the sequencing and analysis of multiple chloroplastic regions is difficult to apply to large collections or large samples of natural populations.
14p vinarcissa 21-03-2023 4 1 Download
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Cytoplasmic male sterility (CMS) is a maternally inherited inability to produce functional pollen found in numerous flowering plant species. CMS is associated with mitochondrial DNA mutation, novel chimeric open reading frames (ORFs), and rearrangement of coding and noncoding regions of the mitochondrial genome.
10p vinarcissa 21-03-2023 2 1 Download
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The domestic turkey (Meleagris gallopavo) is an important agricultural species that is largely used as a meat-type bird. Characterizing genetic variation in populations of domesticated species and associating these variation patterns with the evolution, domestication, and selective breeding is critical for understanding the dynamics of genomic change in these species.
10p vinarcissa 21-03-2023 1 1 Download
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Microsatellites or simple sequence repeats (SSRs) are DNA sequences consisting of 1–6 bp tandem repeat motifs present in the genome. SSRs are considered to be one of the most powerful tools in genetic studies.
9p vinarcissa 21-03-2023 2 1 Download
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Cellobiohydrolase (EC 3.2.1.91) is one of the important enzymes involved in cellulose hydrolysis. In this study, the gene sequences encoding cellobiohydrolase were extracted from the metagenome DNA data of microorganisms surrounding white-rot fungi in Cuc Phuong National Park based on the KEGG database. 73 ORFs encoding cellobiohydrolase were obtained, of which 15 ORFs contained complete genes, 6 ORFs with functional regions.
8p vineville 08-02-2023 5 1 Download
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Production and consumption of pomegranate have been increasing in the world in recent years due to its health benefits to humans. Sunburn is an important physiological disorder caused by high temperature, light, and radiation. With the changes in climatic conditions that have occurred in recent years, the effect of sunburn is increasing and limiting the production and quality of pomegranate.
14p lyhuyenthu 31-01-2023 10 2 Download
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The whole repeat unit of 5S rDNA and the internal transcribed spacer (ITS) of four European Donax species were analysed. After amplifying, cloning and sequencing several 5S and ITS units, their basic features and their variation were described.
13p vihagrid 30-01-2023 11 3 Download
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POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.
16p vihagrid 30-01-2023 5 3 Download
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The transcription factor reservoir and chromatin landscape in activated plasmacytoid dendritic cells
Transcription factors (TFs) control gene expression by direct binding to regulatory regions of target genes but also by impacting chromatin landscapes and modulating DNA accessibility for other TFs. In recent years several TFs have been defined that control cell fate decisions and effector functions in the immune system.
20p vihagrid 30-01-2023 6 3 Download
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DNA barcoding is a short DNA fragment, is used to distinguish between species, especially morphologically similar species and processed specimens that are difficult to distinguish species. For plants, the regions of DNA used as barcodes in identification or taxonomy are usually sequences of the chloroplast genome and the nuclear genome, including the coding regions and the non-coding regions.
9p vilamborghini 12-10-2022 8 4 Download
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In this study, we have sequences nuclear gene region (ITS-rDNA) from 9 individuals of Tacca chantrieri André belonging to three natural populations (Song Hinh Nature Reserve, Phu Yen Province; Cuc Phuong National Park, Ninh Binh province and Ba Vi National Park, Ha Noi city) to investigate genetic character and their phylogenetic inference in the genus Tacca. DNA was extracted from the tissue of leaves.
8p vilamborghini 12-10-2022 7 4 Download
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Recent sequencing technologies enable joint quantification of promoters and their enhancer regions, allowing inference of enhancer–promoter links. We show that current enhancer–promoter inference methods produce a high rate of false positive links. We introduce FOCS, a new inference method, and by benchmarking against ChIAPET, HiChIP, and eQTL data show that it results in lower false discovery rates and at the same time higher inference power.
14p vimichaelfaraday 25-03-2022 13 1 Download
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We describe a highly sensitive, quantitative, and inexpensive technique for targeted sequencing of transcript cohorts or genomic regions from thousands of bulk samples or single cells in parallel. Multiplexing is based on a simple method that produces extensive matrices of diverse DNA barcodes attached to invariant primer sets, which are all pre-selected and optimized in silico.
16p vielonmusk 30-01-2022 21 0 Download