![](images/graphics/blank.gif)
DNA replication initiation
-
Ebook "DNA replication control in microbial cell factories" describes the current knowledge of biochemical mechanisms regulating initiation of DNA replication in Escherichia coli, which focuses on the control of activity of the DnaA protein. Examples of direct linkages between DNA replication and other cellular processes are provided. In addition, similarities of the mechanisms of regulation of DNA replication operating in prokaryotic and eukaryotic cells are identified, and implications for understanding more complex processes, like carcinogenesis are suggested.
56p
manmanthanhla0201
27-02-2024
4
1
Download
-
Ebook "DNA replication: From old principles to new discoveries" eviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field.
581p
lucchinguyen
28-12-2023
5
2
Download
-
POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.
16p
vihagrid
30-01-2023
5
3
Download
-
Early DNA replication occurs within actively transcribed chromatin compartments in mammalian cells, raising the immediate question of how early DNA replication coordinates with transcription to avoid collisions and DNA damage.
27p
viarchimedes
26-01-2022
7
0
Download
-
DNA replication in mammalian cells occurs in a defined temporal order during S phase, known as the replication timing (RT) programme. Replication timing is developmentally regulated and correlated with chromatin conformation and local transcriptional potential.
20p
viarchimedes
26-01-2022
5
0
Download
-
As major regulators of DNA replication in eukaryotes, minichromosome maintenance (MCM) proteins play an important role in the initiation and extension of DNA replication. MCMs and their related genes may be new markers of cell proliferation activity, which is of great significance for the diagnosis and prognosis of cervical cancer.
17p
vimahuateng
26-11-2021
8
1
Download
-
Senescence is a fundamental biological process implicated in various pathologies, including cancer. Regarding carcinogenesis, senescence signifies, at least in its initial phases, an anti-tumor response that needs to be circumvented for cancer to progress. Micro-RNAs, a subclass of regulatory, non-coding RNAs, participate in senescence regulation.
22p
vilarryellison
29-10-2021
8
0
Download
-
Human papillomavirus type 16 (HPV16) is a high-risk HPV type and a potent carcinogen. HPV E1 is one of the most highly conserved proteins and it plays a central role in initiating HPV DNA replication. In current study, we enrolled 161 HPV16-positive cervical cancer patients (case group) and 171 HPV16-positive asymptomatic individuals (control group) in a study to analyse the association between HPV16 E1 genetic mutations and cervical cancer.
8p
vinasaki2711
12-11-2019
16
0
Download
-
Chapter 21 - DNA Replication II: Detailed mechanism. We learned in chapter 20 that DNA replication is at least semidiscontinuous and requires the synthesis of primers before DNA synthesis can begin. We have also learned about some of the major proteins involved in DNA replication in E. coli. Thus, we know that DNA replication is complex and involves more than just a DNA polymerase. This chapter presents a close look at the mechanism of this process in E. coli and in eukaryotes. We will look at the three stages of replication-initiation, elongation, and termination-in a variety of systems.
31p
tangtuy05
30-03-2016
43
3
Download
-
We learned in chapter 20 that DNA replication is at least semidiscontinuous and requires the synthesis of primers before DNA synthesis can begin. We have also learned about some of the major proteins involved in DNA replication in E. coli. Thus, we know that DNA replication is complex and involves more than just a DNA polymerase. This chapter presents a close look at the mechanism of this process in E. coli and in eukaryotes. We will look at the three stages of replication-initiation, elongation, and termination-in a variety of systems.
24p
tangtuy02
08-03-2016
36
1
Download
-
It was shown previously [Riedinger, H. J., van Betteraey-Nikoleit, M & Probst, H. (2002)Eur. J. Biochem.269, 2383–2393] that initiation ofin vivo SV40 DNA replication is reversibly suppressed by hypoxia in a state where viral minichromosomes exhibit a nearly complete set of repli-cation proteins. Reoxygenation triggers fast completion and post-translational modifications.
11p
tumor12
20-04-2013
29
1
Download
-
Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase a-primase complex involved in the initiation of both viral and host DNA replication. Here we demonstrate that DNA repli-cation of the related human pathogenic polyomavirus JC virus (JCV) can be supportedin vitro by DNA polymerase a-primase of either human or murine origin indicating that the mechanism of its strict species specificity differs from that of SV40 and PyV.
8p
fptmusic
16-04-2013
39
3
Download
-
Ribonucleotide reductase is essential for the synthesis of all four dNTPs required for DNA replication. The enzyme is composed of two proteins, R1 and R2, which are both needed for activity. Expression of the R1 andR2mRNAs is restricted to the S-phase of the cell cycle, but the R1 andR2 promoters shownoobvious sequence homologies that could indicate coordination of transcription.
11p
fptmusic
16-04-2013
33
2
Download
-
DNA replication is a fundamental part of the life cycle of all organisms. Not surprisingly many aspects of this process display profound conservation across organisms in all domains of life. The chapters in this volume outline and review the current state of knowledge on several key aspects of the DNA replication process. This is a critical process in both normal growth and development and in relation to a broad variety of pathological conditions including cancer.
496p
japet75
25-02-2013
59
15
Download
-
Replicative helicases are major motor proteins essential for chromosomal DNA replication in prokaryotes. Usually hexameric in solution, their DNA binding property must have different roles at stages ranging from the load-ing onto a branched structure at initiation from the origin to the highly pro-cessive translocation during elongation.
17p
cosis54
08-12-2012
37
1
Download
-
DNA replication is fundamental to cellular life on earth, and replication initiation provides the primary point of control over this process. Replication initiation in all organisms involves the interaction of initiator proteins with one or more origins of replication in the DNA, with subsequent regulated assembly of two replisome complexes at each origin, melting of the DNA, and primed initiation of DNA synthesis on leading and lagging strands.
691p
bachduong1311
07-12-2012
53
4
Download
-
DNA replication, the process of copying one double stranded DNA molecule to produce two identical copies, is at the heart of cell proliferation. This book highlights new insights into the replication process in eukaryotes, from the assembly of pre-replication complex and features of DNA replication origins, through polymerization mechanisms, to propagation of epigenetic states. It also covers cell cycle control of replication initiation and includes the latest on mechanisms of replication in prokaryotes. The association between genome replication and transcription is also addressed.
318p
camchuong_1
04-12-2012
67
9
Download
-
Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Initiation of bacteriophage T4 DNA replication and replication fork dynamics: a review in the Virology Journal series on bacteriophage T4 and its relatives
16p
dauphong1
21-12-2011
51
4
Download
-
Functional cooperation between FACT and the MCM helicase complex constitutes an integral step during DNA replication initiation. However, mode of regulation that underlies the proper functional interaction of FACT and MCM is poorly understood. Methods & Results: Here we present evidence indicating that such interaction is coordinated with cell cycle progression and differential complex formation. We first demonstrate the existence of two distinct FACT-MCM subassemblies, FACT-MCM2/4/6/7 and FACT-MCM2/3/4/5. Both complexes possess DNA unwinding...
11p
toshiba23
18-11-2011
43
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)