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Double-strand DNA breaks
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Recombination is a process by which pieces of DNA are broken and recombined to produce new combinations of alleles. In 1964, Robin Holliday proposed a model for understanding molecular basis of recombination that accounted for heteroduplex formation and gene conversion during recombination. A new modified major model for recombination was given by Jack Szostak and colleagues in 1983, it is called the doublestrand-break model. The initial steps in finding enzymes that carry out recombination were genetic screens for mutants of E. coli that are defective in recombination.
15p
trinhthamhodang6
09-07-2020
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