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Downstream processing
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Transcriptional Co-Activator with PDZ-Binding Motif (TAZ, also known as WWTR1) is a downstream effector of the Hippo pathway, involved in the regulation of organ regeneration and cell differentiation in processes such as development and regeneration.
12p
vikoch
27-06-2024
1
1
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Considerable effort and time is allocated to introducing cell culture and fermentation technology to undergraduate students in academia, generally through a range of courses in industrial biotechnology and related disciplines. Similarly, a large number of textbooks are available to describe the appli-tions of these technologies in industry.
240p
vimeyers
29-05-2024
2
1
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Harvesting microalgae by centrifugation and filtration is very costly, affecting technical and economical feasibility of downstream processing of algal biomas to bioproducts. Flocculation is a potential technique for recovery of algae biomass. Particularly, flocculation using magnetic nanoparticles offers high separation efficiency due to their high surface area and magnetic properties. I
10p
dianmotminh02
03-05-2024
2
1
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Part 1 book "Principles of downstream techniques in biological and chemical processes" by arthor Mukesh Doble includes content: Downstream processing principles, economics and issues; importance of downstream in industrial processes – examples; size reduction, bacterial cell breakage and recovery of intracellular material; isolation of insolubles; product recovery.
139p
muasambanhan10
03-04-2024
4
1
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Part 2 book "Principles of downstream techniques in biological and chemical processes" by arthor Mukesh Doble includes content: Product enrichment, product polishing and finishing, utilities and auxiliary processes, future trends, fundamental concepts.
87p
muasambanhan10
03-04-2024
3
1
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Next-generation sequencing technologies have enabled a dramatic expansion of clinical genetic testing both for inherited conditions and diseases such as cancer. Accurate variant calling in NGS data is a critical step upon which virtually all downstream analysis and interpretation processes rely.
13p
vibransone
28-03-2024
4
2
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Ebook "Molecular farming in plants: Recent advances and future prospects" with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.
284p
coduathanh1122
27-03-2024
5
1
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Fatty acid synthase (FASN) expression is associated with a more aggressive breast cancer phenotype and is regulated downstream of receptor tyrosine kinase (RTK) signaling pathways. Recently, post transcriptional regulation of lipogenic transcripts have been demonstrated as being mediated downstream of serine-arginine rich protein kinase 2 (SRPK2), which acts to phosphorylate serine-arginine rich splicing factors (SRSFs), resulting in RNA binding and various RNA regulatory processes.
13p
vialfrednobel
23-12-2023
5
3
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Cancer stem cells form a rare cell population in tumors that contributes to metastasis, recurrence and chemoresistance in cancer patients. Circular RNAs (circRNAs) are post-transcriptional regulators of gene expres‑ sion that sponge targeted microRNA (miRNAs) to affect a multitude of downstream cellular processes.
15p
vialfrednobel
23-12-2023
3
2
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Nattokinase (NK) is a fibrinolytic enzyme with the potential for fighting cardiovascular diseases (CVD) thanks to its antithrombotic, antihypertensive, anticoagulant, anti-atherosclerotic, and neuroprotective effects. Nattokinase was first discovered and purified from soybean fermented food by Bacillus subtilis natto.
9p
vimulcahy
18-09-2023
9
3
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Microalgal harvesting has still been a challenge to investigators who take their investiment into microalgal production. The cost for microalgal downstream processing is as high as 20% of the total production of biodiesel. Among hundreds of curent methods of biomass harvesting, autoflocculation and bacteria-based aggregation are still being researched and applied in large-scale producuion.
7p
vimulcahy
18-09-2023
9
3
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Concept normalization, the task of linking phrases in text to concepts in an ontology, is useful for many downstream tasks including relation extraction, information retrieval, etc. We present a generate-andrank concept normalization system based on our participation in the 2019 National NLP Clinical Challenges Shared Task Track 3 Concept Normalization.
10p
vighostrider
25-05-2023
4
2
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Tài liệu "Tiếng Anh ngành Công nghệ hóa dầu" cung cấp cho bạn đọc, đặc biết là sinh viên chuyên ngành Hóa dầu một số vốn từ và thành ngữ tiếng Anh thường được sử dụng trong chuyên ngành Công nghệ lọc - hóa dầu. Phần 1 trình bày các nội dung chính sau: Crude oil; Downstream of production; Refining processes; Finising processes; Refinery products;... Mời các bạn cùng tham khảo để nắm nội dung chi tiết.
40p
viwmotors
13-12-2022
19
5
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Fourier-transform infrared spectroscopy (FTIR)is a well-established spectroscopic method in the analysis of small molecules and protein secondary structure. However, FTIR is not commonly applied for inline monitoring of protein chromatography.
8p
viginny
23-12-2022
9
2
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The repertoire of complex proteins produced by the host cell during monoclonal antibody (mAb) production has generated a bottleneck in downstream bioprocessing. Low ppm levels of host cell proteins (HCPs) must be achieved atthe downstream purification process stage to generate an end product suitable for use in humans.
11p
viginny
23-12-2022
4
3
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Pre-packed chromatography columns are routinely used in downstream process development and scaledown studies. In recent years they have also been widely adopted for large scale, cGMP manufacturing of biopharmaceuticals.
8p
viginny
23-12-2022
6
2
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An optimization study of an integrated periodic counter-current chromatography (PCC) process in a monoclonal antibody (mAb) downstream process at lab scale, is presented in this paper. The optimization was based on a mechanistic model of the breakthrough curve in the protein-A capture step.
13p
viginny
23-12-2022
4
2
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Downstream processing (DSP) of large bionanoparticles is still a challenge. The present study aims to systematically compare some of the most commonly used DSP strategies for capture and purification of enveloped viruses and virus-like particles (eVLPs) by using the same staring material and analytical tools.
11p
viginny
23-12-2022
9
3
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Plants are advantageous as biopharmaceutical manufacturing platforms because they allow the economical and scalable upstream production of proteins, including those requiring post-translational modifications, but do not support the replication of human viruses. However, downstream processing can be more labor-intensive compared to fermenter-based systems because the product is often mixed with abundant host cell proteins.
13p
viginny
23-12-2022
9
3
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Monoclonal antibodies (mAb) are used as therapeutics and for diagnostics of a variety of diseases, and novel antibodies are continuously being developed to find treatments for new diseases. Therefore, the manufacturing process must accommodate a range of mAb characteristics. Acid-sensitive mAbs can severely compromise product purity and yield in the purification process due to the potential formation of aggregates.
8p
viginny
23-12-2022
12
3
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