Drug development technologies

Clear cell renal cell carcinoma (ccRCC) is the dominant subtype of renal cancer. With currently available therapies, cure of advanced and metastatic ccRCC is achieved only in rare cases. Here, we developed a workflow integrating different -omics technologies to identify ccRCC-specific HLA-presented peptides as potential drug targets for ccRCC immunotherapy.

24p vibransone 28-03-2024 2 1   Download

Ebook "Drug discovery in Africa: Impacts of genomics, natural products, traditional medicines, insights into medicinal chemistry, and technology platforms in pursuit of new drugs" has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa.

453p coduathanh1122 27-03-2024 1 1   Download

Ebook "Standardization and quality assurance in fluorescence measurements II: Bioanalytical and biomedical applications" is still in its infancy as compared to other prominent analytical and bioanalytical methods. Appropriate quality assurance standards are however a prerequisite for applications in highly regulated fields such as medical diagnostics, drug development, or food analysis. This second of two volumes covers applications of fluorescence for bioanalysis and biomedical diagnostics.

566p manmanthanhla0201 27-02-2024 3 1   Download

Ebook "Biomedical and pharmaceutical applications of electrochemistry" eviews the latest developments in electrochemical science and technology related to biomedical and pharmaceutical applications. In particular, this book discusses electrochemical applications to medical devices, implants, antimicrobially active materials, and drug delivery systems.

470p lamquandat 28-12-2023 2 2   Download

Dealing with uncertainty is one of the critical topics in health technology assessment. The greater decision uncertainty in appraisals, the less clear the clinical- and cost-effectiveness of the health technology. Although the development of targeted cancer therapies (TCTs) has improved patient health care, additional complexity has been introduced in drug appraisals due to targeting more specific populations.

15p vileonardodavinci 23-12-2023 3 2   Download

Part 2 book How to overcome the antibiotic crisis - Facts, challenges, Technologies and future perspectives" includes content: History of antibiotics research, exploitation of fungal biodiversity for discovery of novel antibiotics; new structural templates for clinically validated and novel targets in antimicrobial drug research and development, synthesis of antibiotics, antibiotics clinical development and pipeline..... and other contents.

286p oursky06 17-10-2023 6 3   Download

The United States Office of the National Coordinator for Health Information Technology sponsored the development of a “high-priority” list of drug-drug interactions (DDIs) to be used for clinical decision support. We assessed current adoption of this list and current alerting practice for these DDIs with regard to alert implementation (presence or absence of an alert) and display (alert appearance as interruptive or passive).

8p visteverogers 24-06-2023 2 2   Download

As science and technology has developed, the manner by which drugs can be delivered has grown. Medicines may be taken orally, applied as topical pastes, creams or oils, patches or administered by direct injection to the body. This research explores an alternative method for the delivery of therapeutic compounds to the body. The basis of the study involves the application of traditional medicinal compounds used to cure minor neck and back pains through transdermal topical application, using a textile substrate as the carrier.

128p runthenight07 01-03-2023 8 2   Download

Despite effective strategies to prevent substance use and substance use disorders among college students, challenges remain. As young adults’ preference for and comfortability with web-based technology continues to increase, leveraging innovative approaches to rapidly evolving mHealth technology is critical for the success of lowering the risk for substance use and related consequences in college populations, and especially those at Hispanic Serving Institutions.

12p viferrari 28-11-2022 6 2   Download

The significant development in the construction of microscale cell culture platforms and the interest in bioanalytical analysis have recently resulted in the emergence of a new concept of ‘organ-on-a-chip’ systems. Organon-a-chip is a new three-dimensional (3D) in vitro microfabricated unit that contains a multichannel microfluidic cell culture. Even if many informative and useful data are obtained from animal models and in vitro assays, they are still limited for extrapolation to human systems during drug design and development.

24p tudichquannguyet 29-11-2021 6 1   Download

Hepatitis C is a major public health problem in the United States and worldwide. Outbreaks of hepatitis C virus (HCV) infections associated with unsafe injection practices, drug diversion, and other exposures to blood are difficult to detect and investigate. Effective HCV outbreak investigation requires comprehensive surveillance and robust case investigation. We previously developed and validated a methodology for the rapid and cost-effective identification of HCV transmission clusters.

12p vilarryellison 29-10-2021 13 1   Download

Large-scale genetic screening using CRISPR-Cas9 technology has emerged as a powerful approach to uncover and validate gene functions. The ability to control the timing of genetic perturbation during CRISPR screens will facilitate precise dissection of dynamic and complex biological processes.

15p visilicon2711 20-08-2021 4 1   Download

One of the key elements in the early stages of drug discovery is finding good hits to develop lead compounds. Although HTS has been used as a standardized technology for hit finding, it still bears some challenging drawbacks: expensive and low-quality data. Aiming at the same goal as HTS, virtual screening (VS) has been developed to reduce cost and increase efficiency. Recent studies show that VS can deliver numerous quality hits and a few of them even reach clinical trials.

9p nguaconbaynhay12 01-06-2021 16 1   Download

Understanding the binding mechanism between gold nanoparticles and biomolecules is a fundamental step for numerous applications in biosensors and targeted drug delivery. This study aims to clarify the adsorption behaviors of CYS and GSH on the gold surface using a small gold Au8 cluster as a model reactant.

9p larachdumlanat127 02-01-2021 11 2   Download

Mugwort (Artemisia vulgaris L.) is a familiar herbal medicine and also a daily vegetable. It is one of the ingredients in the famous remedy "Cao ích mẫu" specializing in menstrual disorders or the omelet with mugwort that helps save blood flow to the brain to treat headaches. In both traditional medicine and the new drugs, diseases are usually treated by mugwort as diabetes, epilepsy combination for psychoneurosis, depression, irritability, insomnia, anxiety, and stress. To demonstrate the medicinal uses, the chemical constituents of this herbal were continually studied.

4p larachdumlanat127 02-01-2021 21 2   Download

Biomarkers and target-specific phenotypes are important to targeted drug design and individualized medicine, thus constituting an important aspect of modern pharmaceutical research and development. More and more, the discovery of relevant biomarkers is aided by in silico techniques based on applying data mining and computational chemistry on large molecular databases.

17p viwyoming2711 16-12-2020 15 1   Download

Metabolomics is one of most recent omics technologies. It has been applied on fields such as food science, nutrition, drug discovery and systems biology. For this, gas chromatography-mass spectrometry (GC-MS) has been largely applied and many computational tools have been developed to support the analysis of metabolomics data. Among them, AMDIS is perhaps the most used tool for identifying and quantifying metabolites.

11p vikentucky2711 26-11-2020 22 0   Download

Predicting drug-disease interactions (DDIs) is time-consuming and expensive. Improving the accuracy of prediction results is necessary, and it is crucial to develop a novel computing technology to predict new DDIs.

10p vicoachella2711 27-10-2020 8 1   Download

Computational prediction of drug-target interactions (DTI) is vital for drug discovery. The experimental identification of interactions between drugs and target proteins is very onerous. Modern technologies have mitigated the problem, leveraging the development of new drugs. However, drug development remains extremely expensive and time consuming.

11p vicolorado2711 22-10-2020 15 0   Download

Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic cancer organoids has not yet been broadly implemented in research, and complex organotypic models using organoids in co-culture with stromal and immune cellular components of the tumor have yet to be established.

13p vibaku2711 22-07-2020 10 1   Download