Dynamical network biomarker
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A dynamic single cell-based framework for digital twins to prioritize disease genes and drug targets
Medical digital twins are computational disease models for drug discovery and treatment. Unresolved problems include how to organize and prioritize between disease-associated changes in digital twins, on cellulomeand genome-wide scales. We present a dynamic framework that can be used to model such changes and thereby prioritize upstream regulators (URs) for biomarker- and drug discovery.
21p viellison 28-03-2024 4 2 Download
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Elucidating the dynamic topological changes across different stages of breast cancer, called stage re-wiring, could lead to identifying key latent regulatory signatures involved in cancer progression.
15p vihagrid 30-01-2023 5 3 Download
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Developing effective strategies for signaling the pre-disease state of complex diseases, a state with high susceptibility before the disease onset or deterioration, is urgently needed because such state usually followed by a catastrophic transition into a worse stage of disease.
15p vijeeni2711 24-07-2021 12 0 Download
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Genes that regulate stem cell function are suspected to exert adverse effects on prognosis in malignancy. However, diverse cancer stem cell signatures are difficult for physicians to interpret and apply clinically. To connect the transcriptome and stem cell biology, with potential clinical applications, we propose a novel computational “gene-to-function, snapshot-to-dynamics, and biology-to-clinic” framework to uncover core functional gene-sets signatures.
21p vikentucky2711 24-11-2020 21 1 Download
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The flowering transition which is controlled by a complex and intricate gene regulatory network plays an important role in the reproduction for offspring of plants. It is a challenge to identify the critical transition state as well as the genes that control the transition of flower development.
18p viharuno2711 24-04-2020 11 0 Download
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Dermal health is the outcome of dynamic interactions between the microflora and immune networks to influence the health and overall wellbeing. Biophysical parameters reflect the functional integrity of skin. Biomarkers LL-37 and HBD 2, 3 have broad spectrum amino acid activity that plays role in epithelial defense system.The aim of the present work was to find out exiting correlation between the isolated genera, biophysical parameters and biomarkers of skin.
13p chauchaungayxua4 18-03-2020 12 1 Download
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For U.S. data, we limit our presentation to two return window specifications. The first specification, illustrated in Panel B of Appendix 1, compares mean daily returns occurring during one calendar week centered on the new moon date (new moon date +/- three calendar days) vs. the mean daily returns occurring during the calendar week centered on the full moon date (full moon date +/- three calendar days). Thus, since the lunar month has a length of about 29.5 days, the first specification uses only about half of all available daily returns.
0p bocapchetnguoi 06-12-2012 58 1 Download
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This books highlights the methods and mechanisms by which epigenetics with a focus on DNA methylation can be studied and its impacts on health. In the first part, the first chapter focuses on the modeling and feedback dynamics of DNA methylation, discussing mechanisms and controlling factors as well as DNA sequences pattern analyses and histone modifications and their association with disease initiation. Most methods for detecting methylated-CpG islands rely on chemical conversion of DNA by treatment with bisulfite....
258p yeutinh98 22-09-2012 57 5 Download