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Early stage colon cancer
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Prior studies reported survival benefits from early initiation of adjuvant chemotherapy for stage III colon cancer, but this evidence was derived from studies that may be sensitive to time-related biases.
8p
visusanwojcicki
28-06-2022
14
2
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Ovarian cancer constitutes one of the most lethal gynecologic malignancies for females. Currently, early detection strategies and therapeutic options for ovarian cancer are far from satisfactory, leading to high diagnosis rates at late stages and disease relapses. New avenues of therapy are needed that target key processes in ovarian cancer progression.
20p
vimichaelfaraday
25-03-2022
14
1
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Nuclear alterations are a well-known manifestation of cancer. However, little is known about the early, microscopically-undetectable stages of malignant transformation. Based on the phenomenon of field cancerization, the tissue in the field of a tumor can be used to identify and study the initiating events of carcinogenesis.
10p
virose2711
25-09-2020
12
0
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The aim of this study was to evaluate clinico-pathologic specific predictors of recurrence for stage II/III disease. Improving recurrence prediction for resected stage II/III colon cancer patients could alter surveillance strategies, providing opportunities for more informed use of chemotherapy for high risk individuals.
7p
virose2711
24-09-2020
8
0
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Post-translational modification of histone tails by methylation plays an important role in tumorigenesis. In this study, we investigated the nuclear expression of H3K4me3, H3K9me3 and H4K20me3 in early-stage colon cancer in relation to clinical outcome.
9p
vilisa271
22-09-2020
13
1
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Carbonic anhydrases (CAs) have been implicated in the pathogenesis of human cancers. Carbonic anhydrase VII (CA7), a member of the CA gene family, was recently demonstrated to be expressed in several human tissues including colon. Nevertheless, the expression and clinical relevance of CA7 in colorectal carcinoma (CRC) has not been investigated.
11p
vialabama2711
21-09-2020
10
2
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We sought to assess physician interest in molecular prognosic testing for patients with early stage colon cancer, and identify factors associated with the likelihood of test adoption.
10p
vimale2711
25-08-2020
12
1
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Stage is a key predictor of cancer survival. Complete cancer staging is vital for understanding outcomes at population level and monitoring the efficacy of early diagnosis initiatives.
10p
vibaku2711
22-07-2020
18
2
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MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and bacteria small RNAs in normal and tumor tissue from early stage colon cancer and correlate the expression with clinical parameters.
12p
viputrajaya2711
22-06-2020
7
0
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Approximately 20–30% of patients with pT4 colon cancer develop metachronous peritoneal metastases (PM). Due to restricted accuracy of imaging modalities and absence of early symptoms, PM are often detected at a stage in which only a quarter of patients are eligible for curative intent treatment.
12p
viputrajaya2711
22-06-2020
10
2
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The risk of lymph node positivity in early-stage colon cancer is a parameter that impacts therapeutic recommendations. However, little is known about the effect of age on lymph node positivity in colon cancer with mucosal invasion.
9p
vikuala271
13-06-2020
12
0
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If some forms of independent production have worked closely in unison with Hollywood, others have operated in areas in which Hollywood has chosen not to tread, sometimes teaching valuable lessons to the dominant institution. Necessity has often driven independent operators to be the pioneers of American cinema, exploring new avenues in their search for territories not already colonized by the major studios. The early independents took cinema to parts of rural America, including the gold camps of Alaska, that were not served by the big companies.
63p
khanhchilam
01-04-2013
48
9
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Colorectal cancer (CRC) represents a major public health problem worldwide. Fortunately most CRCs originate from a precursor lesion, the adenoma, which is accessible and removable. This is the rationale for CRC screening programs, which are aimed to diagnose CRC at an early stage or even better to detect and resect the advanced adenoma before CRC has developed. In this background colonoscopy emerges as the main tool to achieve these goals with recent evidence supporting its role in CRC prevention....
286p
phoebe75
19-02-2013
54
5
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Cancer is the second leading cause of death among women. Ideally, it is desirable to prevent or at least to detect cancer in the precancerous stage. Early detection is possible by using Papanicolaou’s (Pap) test for cervical cancer, biopsies for endometrial cancer, and mammography for breast cancer. History plays a more major role in the detection of colorectal cancer, because having first-degree relatives with colon cancer; a history of colorectal, breast, endometrial, or ovarian cancer; and a history of adenomatous polyps or ulcerative colitis are identified risk factors....
165p
hyperion75
21-01-2013
41
5
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Screening is performed earlier and more frequently when there is a strong family history. Randomized, controlled trials have documented that fecal occult blood testing (FOBT) confers a 15 to 30% reduction in colon cancer mortality. Although randomized trials have not been performed for sigmoidoscopy or colonoscopy, well-designed case-control studies suggest similar or greater efficacy relative to FOBT. b In the future, Pap smear frequency may be influenced by HPV testing and the HPV vaccine.
6p
tubreakdance
26-11-2010
65
5
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