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Electrospray ionization
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Ebook "Characterization of protein therapeutics using mass spectrometry" highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity.
408p
coduathanh1122
27-03-2024
2
1
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In ebook "Applications of mass spectrometry in life safety" The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.
238p
manmanthanhla0201
27-02-2024
2
1
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The overuse of antibiotics is losing their effectiveness due to increased antibiotic resistance in bacteria. Over the past two decades, the evaluation of antibiotic residues in the environment has received considerable attention.
11p
viannee
02-08-2023
4
3
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In this work, a chemometric approach to positive electrospray ionization (ESI) optimization for the simultaneous determination of the cyromazine, carbendazim, methomyl, imidacloprid, and thiophanate methyl in vegetable samples by liquid chromatography- mass spectrometry (LC-MS) has been developed.
6p
vicedric
08-02-2023
1
1
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A sensitive and accurate method for the quantification of 1 -Demethyl-1 -nitrosonicotine (NNN) and 4-(methylnitrosamino)-1-(3-Pyridyl)-1-butanone (NNK) in indoor air was developed and validated. To this aim, a novel approach for the collection of two tobacco-specific nitrosamines, using silica sorbent cartridges followed by simplified sample preparation and isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry, was applied.
10p
viginny
23-12-2022
3
3
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The low-cost set-up is based on the flexible microfluidic breadboard approach. To avoid the use of electrically driven devices at the high voltage injection end of the capillary pneumatically actuated pumps and valves are employed. It is coupled to the mass spectrometer with a sheathless electrospray obtained in an electrodeless interface configuration.
4p
viginny
23-12-2022
8
3
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A high sensitive simultaneous determination method of nine steroid hormones including Estrone (E1), estradiol (E2), testosterone (T), dihydrotestosterone (DHT), 17-hydroxyprogesterone (17OH-P4), androstenedione (AN), progesterone (P4), dehydroepiandrosterone (DHEA), and cortisol by liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESIMS/MS) was established in a positive mode using recently developed picolinyl derivatization.
11p
vimelindagates
18-07-2022
8
2
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Nucleic acid amplification technologies (NAAT) are advancing our ability to make rapid molecular diagnoses in patients with serious culture negative infections. This is the first report of PCR coupled to electrospray ionization mass spectrometry use in the evaluation of complicated community acquired pneumonia in a pediatric patient.
5p
viisaacnewton
26-04-2022
16
2
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A determination method of ethylene glycol in animal feed by liquid chromatography coupled with electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS) was developed. The analysis was performed with a C18 column (150 mm × 4.6 mm, 3.5 µm), and a gradient mobile phase of 0.1 % formic acid solution and acetonitrile.
7p
viedison
13-04-2022
11
1
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Separation of morphine and its impurities (related substances specified in relevant European Pharmacopoeia monographs, as well as the other naturally occurring coextracted alkaloids) was obtained within a close retention window on a reverse phase HPLC column, eluted with optimized gradient, consisting of methanol and 5 mM ammonium formate, adjusted to pH 10.2. Systematic optimization of the chromatographic conditions was carried out using design of experiments.
13p
tudichquannguyet
29-11-2021
11
1
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The new benzimidazolium derivative (SM-1) salt with ion exchange from the (SM-0)was fabricated and characterized by protonnuclear magnetic resonance (1 H-NMR), carbon-nuclear magnetic resonance (13C-NMR), Fourier-transform infrared spectroscopy (FTIR), electrospray ionization (EIS-MS), thermal analysis (TG), cyclic voltammetry (CV), and ultraviolet-visible spectroscopy (UV-vis), for electrolytes (liquid or dried) in the DSSC charge transportation mechanism.
11p
tudichquannguyet
29-11-2021
18
0
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Two naphthalene pyrazole ligands were synthesized using KOH/DMSO and Cu catalyst and characterized with FT-IR, ESIMS, 1H, and 13C NMR spectroscopies. The crystal structures of 1-(2-methylnaphthalen-1-yl)-1H-pyrazole (MeNap-Pz) ligand have been determined with X-ray crystal structure analysis. Reaction of the ligands with Cu(NO3)2x3.5H2O gave two new complexes and characterized with magnetic susceptibility, molar conductance, FT-IR, LCMS-MS, ICP-OES, NMR, thermogravimetric analysis, and ESR spectra.
24p
tudichquannguyet
29-11-2021
17
0
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Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples, and is a promising novel diagnostic tool when combined with machine learning which discriminates malignant spectrum patterns from others.
9p
vianrose2711
27-04-2021
12
1
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The liquid chromatography tandem mass spectrometry with electrospray ionization (ESI) source in multiple reactions monitoring (MRM) mode has been used to detect five allergen including milk, egg, peanut, soyabean, and walnut in milk, dairy products, and confectionery. The allergenic proteins from food matrices were extracted with an extraction buffer (50 mM of TRIS- saline, 2 M of urea, and 25 mM of DTT) and then enzymatically digested with trypsin to form peptides. The peptides were eventually detected on a LC-MS/MS Triple Quad 5500 system from AB SCIEX.
8p
kethamoi9
01-12-2020
8
1
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Phellinus gilvus (Schwein.) Pat, a species of ‘Sanghuang’, has been well-documented for various medicinal uses, but the genome information and active constituents are largely unknown. Here, we sequenced the whole-genome of P. gilvus, identified phenylpropanoids as its key anti-cancer components, and deduced their biosynthesis pathways. A 41.11-Mb genome sequence was assembled and the heatmap created with high-throughput chromosome conformation capture techniques data suggested all bins could be clearly divided into 11 pseudochromosomes. Cellular experiments showed that P.
11p
covid19
14-06-2020
26
0
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Flickingeria fimbriata is commonly applied in China as a traditional Chinese medicine (TCM), however the quality control of it is incomplete. In this work, we aim to identify and quantify the structures of C-glycosyl flavones in F. fimbriata.
20p
vijiraiya2711
27-05-2020
13
0
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Membrane lipid composition associates closely with membrane stability and fluidity under water stress. In this study, lipidomic analyses based on electrospray ionization mass spectrometry (ESI-MS/MS) were carried out to explore dynamic changes of membrane lipids in term of molecular species caused by PEG (Polyethylene glycol-6000)-induced water stress in wheat seedlings.
15p
viharuno2711
21-04-2020
7
1
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Coscinium fenestratum (Gaertn.) Colebr, commonly called as daruharidra which belongs to Menispermaceae family is rich with bioactive secondary metabolites that might signify valuable leads in the production of new pharmaceutical agents. The metabolite accumulation in the plants varies with the environmental factors, expression level of enzymes, climatic conditions etc. To evaluate the difference of metabolite in the cultivated vine, the sample was analysed by High performance Liquid Chromatography-Mass Spectrometry (HPLC-MS).
8p
nguaconbaynhay1
04-12-2019
19
1
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Pseudomonas aeruginosa can cause disease and also can be isolated from the skin of healthy people. Additionally, it exhibits certain antimicrobial effects against other microorganisms.
7p
vicaracas2711
27-11-2019
8
0
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In this study, systematic separation and subsequent pharmacological activity studies were carried out to identify cytotoxic natural products from the dried stems of Millettia pachyloba Drake. Five previously undescribed isoflavones, pachyvones A–E; one previously undescribed xanthone, pachythone A; and twenty-two known compounds were obtained. The structures of these compounds were assigned on the basis of 1D/2D NMR data and high-resolution electrospray ionization mass spectroscopy analysis.
11p
trinhthamhodang1
14-11-2019
18
1
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