Emergence of drug

HIV-1 protease is a pivotal enzyme in the later stages of the viral life cycle which is responsible for the processing and maturation of the virus particle into an infectious virion. As such,HIV-1proteasehasbecomean important target for the treatment ofAIDS, and efficient drugs have beendeveloped. However, negative side effects and fast emerging resistance to the current drugs have necessitated the development of novel chemical entities in order to exploit different phar-macokinetic properties as well as new interaction patterns....

9p awards 05-04-2013 32 2   Download

An emerging body of evidence supports a key role for the endocannabinoid system in numerous physiological and pathological mechanisms of the cen-tral nervous system. In the recent past, many experimental studies have examined the putative protective or toxic effects of drugs interacting with cannabinoid receptors or have measured the brain levels of endocannabi-noids inin vitro and in vivo models of cerebral ischemia.

11p vinaphone15 27-02-2013 40 3   Download

Tuberculosis (TB) continues to be a major cause of morbidity and mortal-ity worldwide. The increasing emergence and spread of drug-resistant TB poses a significant threat to disease control and calls for the urgent devel-opment of new drugs. The tryptophan biosynthetic pathway plays an important role in the survival of Mycobacterium tuberculosis.

11p vinaphone15 27-02-2013 48 2   Download