FDR estimation
-
Increasing number of individuals will have frst-degree relatives (FDRs) diagnosed with colorectal cancer (CRC), as a second primary malignancy (CRCa-2) after a non-CRC cancer. We aimed to estimate whether and to what extent a family history of CRCa-2 is associated with an increased CRC risk.
8p vialfrednobel 23-12-2023 6 3 Download
-
In mass spectrometry-based proteomics, protein identification is an essential task. Evaluating the statistical significance of the protein identification result is critical to the success of proteomics studies. Controlling the false discovery rate (FDR) is the most common method for assuring the overall quality of the set of identifications.
10p vitzuyu2711 29-09-2021 12 1 Download
-
Complex designs are common in (observational) clinical studies. Sequencing data for such studies are produced more and more often, implying challenges for the analysis, such as excess of zeros, presence of random effects and multi-parameter inference.
7p vikentucky2711 26-11-2020 9 1 Download
-
When many (up to millions) of statistical tests are conducted in discovery set analyses such as genome-wide association studies (GWAS), approaches controlling family-wise error rate (FWER) or false discovery rate (FDR) are required to reduce the number of false positive decisions.
10p viconnecticut2711 28-10-2020 10 1 Download
-
One of the most important steps in peptide identification is to estimate the false discovery rate (FDR). The most commonly used method for estimating FDR is the target-decoy search strategy (TDS). While this method is simple and effective, it is time/space-inefficient because it searches a database that is twice as large as the original protein database.
6p vicolorado2711 23-10-2020 9 1 Download
-
In shotgun proteomics, database searching of tandem mass spectra results in a great number of peptide-spectrum matches (PSMs), many of which are false positives. Quality control of PSMs is a multiple hypothesis testing problem, and the false discovery rate (FDR) or the posterior error probability (PEP) is the commonly used statistical confidence measure.
17p vicolorado2711 22-10-2020 13 0 Download