Functional prediction

This research aimed to create a robust signature with hypoxia-related genes to predict the prognosis of breast cancer patients. The function of hypoxia genes was further studied through cell line experiments.

12p vishanshan 27-06-2024 3 1   Download

Ovarian cancer is the first cause of death from gynecological malignancies mainly due to development of chemoresistance. Despite the emergence of PARP inhibitors, which have revolutionized the therapeutic management of some of these ovarian cancers, the 5-year overall survival rate remains around 45%.

9p vikoch 27-06-2024 1 1   Download

The purpose of this study was to develop a functional clinical nomogram for predicting 8-year overall survival (OS) of patients with prostate cancer (PCa) primary based on peripheral lymphocyte.

10p vikoch 27-06-2024 2 1   Download

Cancer cachexia is associated with impaired functional and nutritional status and worse clinical outcomes. Global Leadership Initiative in Malnutrition (GLIM) consensus recommended the application of GLIM criteria to diagnose malnutrition in patients with cachexia. However, few previous study has applied the GLIM criteria in patients with cancer cachexia.

11p vikoch 27-06-2024 2 1   Download

Apolipoprotein A1 (ApoA1) is a member of the apolipoprotein family with diverse functions. It is associated with the pathogenesis and prognosis of several types of tumors. However, the role of serum apolipoprotein A1 (ApoA1) in the prognosis of patients with diffuse large B-cell lymphoma (DLBCL) remains unclear. This study aimed to elucidate its influence on clinical outcomes in patients with DLBCL.

9p vikoch 27-06-2024 2 1   Download

Ebook Rules of thumb for maintenance and reliability engineers presents the following content: Understanding maintenance and reliability, the functional maintenance organization and its people, preventive maintenance program, predictive maintenance program, reliability processes, key performance indicators, total productive maintenance,…

314p zizaybay1103 29-05-2024 4 1   Download

Ebook "The fish production potential of the baltic sea: A new general approach for optimizing fish quota including a holistic management plan based on ecosystem modeling" deals with the quantification of what these functional groups of organisms eat, how much they eat, when they eat, and how this relates to basic abiotic properties of the system, such as salinity, water temperature, oxygen conditions and nutrient concentrations.

402p giangdongdinh 28-05-2024 2 1   Download

The authors propose a novel BCMO-DNN algorithm for vibration optimization of functionally graded porous microplates. The theory is based on a unified framework of higher-order shear deformation theory and modified strain gradient theory. A hybrid combination of deep learning neural network and balancing composite motion optimization is developed to solve the optimization problems and predict stochastic vibration behaviors of functionally graded porous microplates with uncertainties of material properties.

12p dathienlang1012 03-05-2024 3 0   Download

The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.

18p dianmotminh02 03-05-2024 2 1   Download

In this continuity, the potentiality of D. citrea essential oil was subjected to screening research. The extract yield was obtained experimentally and its chemical characterization was acquired by gas chromatography-mass spectrometry (GC-MS). The determined data was subjected as the input for computational implementations, including density functional theory calculation, molecular docking simulation, and biopharma-potential predicting analyses.

20p dianmotminh02 03-05-2024 1 1   Download

Ebook "Discovering biomolecular mechanisms with computational biology" present critical reviews of methods and high-impact applications in computational biology that lead to results that also non-bioinformaticians must know to design efficient experimental research plans. Discovering Biomolecular Mechanisms with Computational Biology also summarizes non-trivial theoretical predictions for regulatory and metabolic networks that have received experimental confirmation.

152p ladongphongthanh1008 22-04-2024 8 2   Download

Part 1 book "Advanced control of electrical drives and power electronic converters" includes content: Sensor less control of polyphase induction machines, adaptive position tracking with hard constraints—barrier lyapunov functions approach, predictive position control of a two mass system with an induction motor in a wide range of speed changes, selected methods for a robust control of direct drive with a multi mass mechanical load,... and other contents.

156p dianmotminh00 22-04-2024 6 4   Download

This paper is aimed at quickly predicting the dynamic behavior of functionally graded plates using nontraditional computational approaches consisting of artificial neural networks (ANN) and extreme gradient boosting (XGBoost).

11p viohoyo 25-04-2024 4 2   Download

This paper presents a theoretical study that describes the fiber bridging mechanism under tensile stress using a closed-form analytical function. This proposed analytical model allows estimating the stress at a crack opening where the fiber orientation is represented by a Gaussian-like periodic distribution function.

14p viohoyo 25-04-2024 2 2   Download

Measures of the adaptive immune response have prognostic and predictive associations in melanoma and other cancer types. Specifically, intratumoral T cell density and function have considerable prognostic and predictive value in skin cutaneous melanoma (SKCM).

11p vibransone 28-03-2024 2 2   Download

The findings of this review article are important for managers and chief supply chain officers in that they can better simplify the chains through the adoption of 3-D printing infrastructure, thereby insulating their businesses from the cascading effects of black swan events. I find support for the hypothesis that the adoption of 3-D printing infrastructure in manufacturing supply chain infrastructure leads to simplification of the networks.

16p longtimenosee07 29-03-2024 7 2   Download

The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their functional implications may be unclear.

10p vioraclene 31-03-2024 4 2   Download

Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermethylation in HPV(+) oropharyngeal cancers, but only few consistent target genes have been so far described, and the evidence of a functional impact on gene expression is still limited.

12p vioraclene 31-03-2024 3 1   Download

Enhancers are distal cis-regulatory elements required for cell-specific gene expression and cell fate determination. In cancer, enhancer variation has been proposed as a major cause of inter-patient heterogeneity— however, most predicted enhancer regions remain to be functionally tested.

25p vibransone 28-03-2024 5 2   Download

Protein truncating variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 are associated with increased breast cancer risk, but risks associated with missense variants in these genes are uncertain.

17p viellison 28-03-2024 7 2   Download