Functionally active proteins
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Hsa_circ_001726 functioned as an oncogene in HCC, which was derived from CCT2 and regulated by E2F6. Hsa_circ_001726 elevated PRMT9 expression by sponging miR-671-5p, and then activated Notch signaling pathway, thereby accelerating malignant phenotypes of HCC. Therefore, targeting hsa_circ_001726 may be a new avenue for HCC treatment.
17p vishanshan 27-06-2024 2 1 Download
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Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of AMPKα2 in the LIHC tumor immune environment is unclear.
17p vikoch 27-06-2024 2 1 Download
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p vikoch 27-06-2024 1 1 Download
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Pediatric low-grade glioma (pLGG) is essentially a single pathway disease, with most tumors driven by genomic alterations affecting the mitogen-activated protein kinase/ERK (MAPK) pathway, predominantly KIAA1549::BRAF fusions and BRAF V600E mutations. This makes pLGG an ideal candidate for MAPK pathway-targeted treatments.
11p vikoch 27-06-2024 1 1 Download
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The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.
18p dianmotminh02 03-05-2024 2 1 Download
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Ebook "CtBP family proteins" are unique in several aspects. They were the first among proteins containing a metabolic enzyme fold to be implicated in transcriptional regulation. The vertebrate CtBPs exhibit distinct nuclear and cytosolic activities. The crystal struaures of CtBPl and molecular modeling studies have illuminated the molecular basis of its dual activity and the interaction with target peptides.
131p ladongphongthanh1008 22-04-2024 5 2 Download
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Ebook "APC proteins" aimed to provide an overview of the diverse functions performed by the Ape protein. As summarised in a short final chapter by Trainer, heterozygosity ofApe leads to a number ofextracolonic manifestations that further support this emerging picture ofthe Ape protein as an active contributor to many different cellular functions.
146p ladongphongthanh1008 22-04-2024 3 2 Download
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Basal cell carcinoma (BCC) of the skin is the most common form of human cancer, with more than 90% of tumours presenting with clear genetic activation of the Hedgehog pathway. However, polygenic risk factors affecting mechanisms such as DNA repair and cell cycle checkpoints or which modulate the tumour microenvironment or host immune system play significant roles in determining whether genetic mutations culminate in BCC development.
12p vibransone 28-03-2024 3 2 Download
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PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients.
17p vibransone 28-03-2024 1 1 Download
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Ebook "SUMO regulation of cellular processes (Second edition)" of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.
413p cotieubac1004 15-03-2024 1 0 Download
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Ebook "Kinesin protocols (Methods in molecular biology, Volume 164)" present a wide range of domain organizations with a motor domain located at different positions in the molecule. Their motility properties are also variable in directionality, velocity, and such other characteristics as bundling activity and processivity. Finally, and most important, they practicipate in a multitude of cellular functions.
228p manmanthanhla0201 26-02-2024 3 1 Download
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Ebook "Aminoacyl-tRNA synthetases in biology and medicine" will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed.
355p nhanphanguyet 28-01-2024 6 2 Download
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Ebook "Food nanoscience and nanotechnology" have increased the nutritional and functional properties of a number of food products and have aided in food preservation through the addition of antimicrobials or the reduction of water activity. These and many other applications have emerged in recent years to transform food science and technology. This book proposes to look at some of these applications and their effect on food production and innovation.
307p nhanphanguyet 28-01-2024 6 2 Download
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In ebook "Nuclear dynamics: Molecular biology and visualization of the nucleus" the dynamics of nuclear structures described furnish the basis for a comprehensive understanding of how the higher-order organization and function of the nucleus is established and how it correlates with the expression of a variety of vital activities such as cell proliferation and differentiation. The resulting volume creates an invaluable source of reference for researchers in the field.
285p tachieuhoa 28-01-2024 6 2 Download
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Ebook "Animal lectins: Form, function and clinical applications (Volume 1)" presents up-to-date knowledge of animal lectins. Detailed descriptions on biological activities, tissue and/or subcellular distribution, molecular structure, gene organization, possible functions, clinical applications, lectin-ligand interactions and their intervention for therapeutic purposes are provided.
1122p tachieuhoa 28-01-2024 8 2 Download
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Ebook "Glucose transport: Methods and protocols" explores methods used to examine the structure-function relationship of glucose transporters both in vitro and ex vivo.
270p lucchinguyen 28-12-2023 3 2 Download
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Ebook "Potassium channels: Methods and protocols" provides readers with the latest techniques and approaches used to study K+ channels. There are a wide range of topics covered in the book, such as channel structure; K+ channels and their roles in physiology and disease; single-molecule FRET; proteins expression levels in vivo; real-time correlation of channel activity; gating; pharmacology; physiological functions; and channelopathies.
346p lucchinguyen 28-12-2023 3 2 Download
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Damaging alterations in the BRCA1 gene have been extensively described as one of the main causes of hereditary breast and ovarian cancer (HBOC).BRCA1 alterations can lead to impaired homologous recombination repair (HRR) of double-stranded DNA breaks, a process which involves the RING, BRCT and coiled-coil domains of the BRCA1 protein.
13p vischultz 20-10-2023 1 1 Download
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Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and pleiotropic understanding so far.
31p vischultz 20-10-2023 4 1 Download
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MAPK1 promotes the metastasis and invasion of gastric cancer as a bidirectional transcription factor
The Mitogen-activated protein kinase 1 (MAPK1) has both independent functions of phosphorylating histones as a kinase and directly binding the promoter regions of genes to regulate gene expression as a transcription factor.
13p visharma 20-10-2023 8 2 Download