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Gene architecture
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Inter-tissue molecular interactions are critical to the function and behavior of biological systems in multicellular organisms, but systematic studies of interactions between tissues are lacking. Also, existing studies of inter-tissue interactions are based on direct gene expression correlations, which can’t distinguish correlations due to common genetic architectures versus biochemical or molecular signal exchange between tissues.
15p
vioraclene
31-03-2024
8
2
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Part 1 book "Molecular cell biology" includes content: Life begins with cells, chemical foundations, protein structure and function, basic molecular genetic mechanisms, biomembranes and cell architecture, integrating cells into tissues, transport of ions and small molecules across cell membranes, cellular energetics, molecular genetic techniques and genomics, molecular structures of genes and chromosomes, transcriptional control of gene expression.
490p
muasambanhan07
18-02-2024
2
2
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Telomere dysfunction results in aneuploidy, and ongoing chromosomal abnormalities. The threedimensional (3D) nuclear organization of telomeres allows for a distinction between normal and tumor cells. On the other hand, aurora kinase genes (AURKA and AURKB) play an important role regulating the cell cycle.
11p
vialfrednobel
23-12-2023
5
3
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Part 2 book "Bovine genomics" includes contents: Bovine genome architecture, bovine epigenetics and epigenomics, mapping quantitative trait loci, genome wide association studies and linkage disequilibrium in cattle, genomic selection in beef cattle, impact of high throughput genotyping and sequencing on the identification of genes and variants underlying phenotypic variation in domestic cattle.
149p
oursky04
14-09-2023
9
3
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In rice, a variant of DEP1 gene results in erect panicle architecture, well-developed vascular bundles, an increase in the number of grains per panicle and a consequent increase in the grain yield.
10p
vinarcissa
21-03-2023
1
1
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To optimize marker-assisted selection programs, knowledge of the genetic architecture of phenotypic traits is very important for breeders. Generally, most phenotypes, e.g. morphological and physiological traits, are quantitatively inherited, and thus detection of the genes underlying variation for these traits is difficult.
8p
vinarcissa
21-03-2023
5
1
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African Americans have been treated as a representative population for African ancestry for many purposes, including pharmacogenomic studies. However, the contribution of European ancestry is expected to result in considerable differences in the genetic architecture of African American individuals compared with an African genome.
15p
vinarcissa
21-03-2023
2
1
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Fertility is considered an important economic trait in dairy cattle. Most studies have investigated cow fertility while bull fertility has received much less consideration. The main objective of this study was to perform a comprehensive genomic analysis in order to unravel the genomic architecture underlying sire fertility in Holstein dairy cattle.
11p
vinarcissa
21-03-2023
4
1
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There has been considerable interest in discovery of the genetic architecture of complex traits, particularly age-related neurodegenerative disorders. To predict disease risk and to understand its genetic basis in humans, it is necessary to study animal models.
17p
vinarcissa
21-03-2023
3
1
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The serotonin 2A receptor is widely implicated in genetic association studies and remains an important drug target for psychiatric, neurological, and cardiovascular conditions. RNA sequencing redefined the architecture of the serotonin 2A receptor gene (HTR2A), revealing novel mRNA transcript isoforms utilizing unannotated untranslated regions of the gene.
15p
vinarcissa
21-03-2023
6
1
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Association studies in recently admixed populations are extremely useful to identify the genetic architecture of pigmentation, due to their high genotypic and phenotypic variation. However, to date only four Genome-Wide Association Studies (GWAS) have been carried out in these populations.
16p
vihagrid
30-01-2023
7
3
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Knock-out of TERMINAL FLOWER 1 genes altered flowering time and plant architecture in Brassica napus
TERMINAL FLOWER 1 (TFL1) is a member of phosphatidylethanolamine-binding protein (PEBP) family, which plays an important role in the determination of floral meristem identity and regulates flowering time in higher plants.
13p
vihagrid
30-01-2023
10
3
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Plant architecture-related traits (e.g., plant height (PH), number of nodes on main stem (NN), branch number (BN) and stem diameter (DI)) and 100-seed weight (100-SW) are important agronomic traits and are closely related to soybean yield.
14p
vihagrid
30-01-2023
6
4
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The architectural transcriptional regulator high-mobility group AT-hook 2 (HMGA2) is an oncofetal protein which has been reported to be ectopically expressed in a variety of cancers. A high expression of HMGA2 in human renal cell carcinoma (RCC) is related with tumor invasiveness and poor prognosis.
8p
vikolindagrabar
27-07-2022
4
2
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Alternative splicing, particularly through intron retention and exon skipping, is a major layer of pre-translational regulation in eukaryotes. While intron retention is believed to be the most prevalent mode across non-animal eukaryotes, animals have unusually high rates of exon skipping. However, when and how this high prevalence of exon skipping evolved is unknown.
21p
vigalileogalilei
27-02-2022
10
1
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The three-dimensional (3D) organization of chromosomes is linked to epigenetic regulation and transcriptional activity. However, only few functional features of 3D chromatin architecture have been described to date.
15p
vigalileogalilei
27-02-2022
13
1
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Filamentous plant pathogen genomes often display a bipartite architecture with gene-sparse, repeatrich compartments serving as a cradle for adaptive evolution. The extent to which this two-speed genome architecture is associated with genome-wide DNA modifications is unknown.
16p
vigalileogalilei
27-02-2022
23
1
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Polycomb Repressive Complexes 2 (PRC2) are multi-protein chromatin modifiers that are evolutionarily conserved among eukaryotes and play key roles in the regulation of gene expression, notably through the trimethylation of lysine 27 of histone H3 (H3K27me3). Although PRC2-mediated gene regulation has been studied in many organisms, few studies have explored in depth the evolutionary conservation of PRC2 targets.
15p
vialfrednobel
29-01-2022
5
0
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Despite their nearly identical genomes, males and females differ in risk, incidence, prevalence, severity and age-at-onset of many diseases. Sexual dimorphism is also seen in human autosomal gene expression, and has largely been explored by examining the contribution of genotype-by-sex interactions to variation in gene expression.
10p
vialfrednobel
29-01-2022
3
0
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In a recent study, Petrovski and Goldstein reported that (non-Finnish) Europeans have significantly fewer nonsynonymous singletons in Online Mendelian Inheritance in Man (OMIM) disease genes compared with Africans, Latinos, South Asians, East Asians, and other unassigned non-Europeans.
3p
vialfrednobel
29-01-2022
14
0
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