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Gene candidates
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The genetic risk for pancreatic cancer is often shared with breast cancer susceptibility genes, most notably BRCA2, PALB2, ATM and BRCA1. Therefore, we hypothesized that additional shared genetic etiologies might be uncovered by studying families presenting with both breast and pancreatic cancer.
9p
vikoch
27-06-2024
2
1
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Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC ) stands out as a potential candidate for new therapies.
17p
vikoch
27-06-2024
3
1
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Heterotaxy (Htx) syndrome comprises a class of congenital disorders resulting from malformations in left-right body patterning. Approximately 90% of patients with heterotaxy have serious congenital heart diseases; as a result, the survival rate and outcomes of Htx patients are not satisfactory.
13p
vibransone
28-03-2024
3
2
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Disagreements over genetic signatures associated with disease have been particularly prominent in the field of psychiatric genetics, creating a sharp divide between disease burdens attributed to common and rare variation, with study designs independently targeting each.
14p
vioraclene
31-03-2024
2
2
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Exon-targeted microarrays can detect small (
15p
vioraclene
31-03-2024
5
2
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Expression quantitative trait loci (eQTL) databases represent a valuable resource to link diseaseassociated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation.
16p
vioraclene
31-03-2024
4
2
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Large-scale cohort-based whole exome sequencing of individuals with neurodevelopmental disorders (NDDs) has identified numerous novel candidate disease genes; however, detailed phenotypic information is often lacking in such studies.
11p
vioraclene
31-03-2024
5
2
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Genome-wide association studies (GWAS) have identified over 56 susceptibility loci associated with Alzheimer’s disease (AD), but the genes responsible for these associations remain largely unknown.
11p
vibransone
28-03-2024
9
2
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Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes.
26p
vibransone
28-03-2024
2
2
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While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.
18p
viellison
28-03-2024
1
1
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Whole-exome sequencing (WES) and whole-genome sequencing (WGS) have become indispensable tools to solve rare Mendelian genetic conditions. Nevertheless, there is still an urgent need for sensitive, fast algorithms to maximise WES/WGS diagnostic yield in rare disease patients.
19p
vicwell
29-02-2024
6
2
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Ebook "Retinal degenerative diseases: Laboratory and therapeutic investigations (Advances in experimental medicine and biology, Volume 664)" provides readers with contents including: basic science underlying retinal degeneration; molecular genetics and candidate genes; diagnostic, clinical, cytopathological and physiologic aspects of retinal degeneration; macular degeneration;...
715p
duongthandue0501
28-02-2024
5
1
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In ebook "Animal models of T cell mediated skin diseases" animal models are of key importance for target identification and lead compound discovery and optimization. Indeed, most pharmaceutical companies base decisions on the clinical development of candidate compounds and on results obtained from animal research in disease models.
302p
manmanthanhla0201
27-02-2024
8
2
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Part 1 book "Animal behavior - An evolutionary approach" includes content: Free ranging macaque mothers exaggerate tool using behavior when observed by offspring, altered behavior and digestive outcomes in adult male rats primed with minimal colon pain as neonates - social transmission of avoidance behavior under situational change in learned and unlearned rats,... and other contents.
160p
oursky10
07-12-2023
6
3
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Breast cancer susceptibility gene (BRCA) mutation carriers are at an increased risk for breast, ovarian, prostate and pancreatic cancers. However, the role of BRCA is unclear in colorectal cancer; the results regarding the association between BRCA gene mutations and colorectal cancer risk are inconsistent and even controversial.
10p
vioracle
29-09-2023
7
3
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During the recent decade, uncultured bacteria have been special interest as potential candidates for discovering novel antibacterial compounds. Two strains C101 and C102 were negative Gram bacteria, only growing on low nutrient media as R2A/3, NB/3, LB/10 and R4/10 compared to the usual.
8p
vimulcahy
18-09-2023
6
3
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Cilia and flagella-associated protein (CFAP) is a well-known protein family that plays a vital role in the spermatogenic process. Recently, the gene CFAP65, which encodes the cilia- and flagellaassociated protein 65, has been focused on as a new candidate for male infertility.
6p
vimulcahy
18-09-2023
4
3
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Porcine mucin 4 (MUC4) is a candidate gene for controlling the adhesion of the enterotoxigenic Escherichia coli (ETEC) F4 receptor. Polymorphisms of the MUC4 gene have been used as markers to identify the susceptibility of neonatal diarrhea in piglets for breeding selection.
8p
viengels
25-08-2023
3
2
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Investigating the molecular mechanisms of symptoms is a vital task in precision medicine to refine disease taxonomy and improve the personalized management of chronic diseases. Although there are abundant experimental studies and computational efforts to obtain the candidate genes of diseases, the identification of symptom genes is rarely addressed.
8p
visteverogers
24-06-2023
9
2
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Inadequate response to corneal laser refractive surgery, e.g., ectatic corneal diseases, may not be identified by conventional examinations, hence creating therapeutic uncertainty. Herein we demonstrate the application of genetic prescreening to augment preassessment for corneal laser refractive surgery and highlight the ability to prevent the possibility of enrolling a subject at risk for developing ectatic corneal diseases.
8p
vigamora
23-05-2023
6
3
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