Genetic medicine

Updating researchers on phenomenal progress in the field of molecular medicine the Encyclopedia of Medical Genomics and Proteomics offers trail-blazing studies and authoritative contributions from more than 400 specialists. Topics include: Molecular diagnostics; Genomics, microbiology, genetics, and pharmacogenetics; Management of infectious, neoplastic, and genetic diseases;...

1391p vimeyers 29-05-2024 3 2   Download

Ebook "Dyneins: Structure, biology and disease" offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. Broad-based up-to-date resource for the dynein class of molecular motors.

641p dongmelo 27-05-2024 6 2   Download

Oxidoreductases (ORases) are enzymes that catalyze oxidation and reduction reactions in cells or extracellular compartments of the body. Genetic mutations and other factors that affect ORase activity have been implicated in a range of diseases, especially inherited metabolic disorders. Aldose reductase, sorbitol dehydrogenase, xanthine oxidoreductase are the ORases with relevance to diabetes pathology.

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Part 1 book "Illustrated textbook of pediatrics" includes content: The child in society; history and examination; normal child development, hearing and vision; developmental problems and the child with special needs; care of the sick child; paediatric emergencies; accidents, poisoning and child protection; genetics, perinatal medicine; neonatal medicine; growth and puberty; nutrition

218p zizaybay1101 30-04-2024 5 2   Download

Ebook "Alginates: Biology and applications" provides an overview of the state of art of alginate material properties, genetics and the molecular mechanisms underlying alginate biosynthesis as well as applications of tailor-made alginates in medicine, food and biotechnology. Topics treated are: material properties of alginates, alginate production: precursor biosynthesis, polymerization and secretion, bacterial system for alginate uptake and degradation, enzymatic alginate modification,...

269p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Early life origins of health and disease" is a new book which presents and discusses the many factors that may have impact on normal development. In a concise and readable manner, the authors consider both the proven and suggestive evidence that the high prevalence of hypertension, diabetes, obesity and, in some populations, kidney disease, may not be all due to genetics or adult environment alone.

246p tracanhphuonghoa1007 22-04-2024 4 1   Download

Ebook "Engineering and application of pluripotent stem cells" reviews the latest biotechnological advances with pluripotent stem cells, exploring their application in tissue engineering and medicinal chemistry. Chapters from expert contributors cover topics such as the production of transgene-free induced pluripotent stem cells (iPSCs), expansion, controlled differentiation and programming of pluripotent stem cells, and their genetic instability. Particular attention is given to the application of the pluripotent stem cells for vascularision of engineered tissue and for drug screening.

232p tracanhphuonghoa1007 22-04-2024 3 2   Download

Part 1 book "Essentials of internal medicine" includes content: Internal medicine in the 21st century—best practice, best outcomes; evidence based medicine and critical appraisal of the literature; ethics; clinical pharmacology and toxicology; genetics; medical imaging for internists; pulmonology; cardiology; hypertension; nephrology; endocrinology; gastroenterology.

394p muasambanhan10 11-04-2024 2 1   Download

Part 2 book "Biotechnology" by author John E. Smith includes content: Plant and forest biotechnology, animal and insect biotechnology, food and beverage biotechnology, biotechnology and medicine, stem cell biotechnology, protection of biotechnological inventions, safety in biotechnology, public perception of biotechnology - genetic engineering – safety, social, moral and ethical considerations, looking to the future.

134p muasambanhan10 06-04-2024 0 0   Download

Accumulating evidence suggests alternative splicing (AS) is a co-transcriptional splicing process not only controlled by RNA-binding splicing factors, but also mediated by epigenetic regulators, such as chromatin structure, nucleosome density, and histone modification. Aberrant AS plays an important role in regulating various diseases, including cancers.

11p vibransone 28-03-2024 5 2   Download

Base substitution catalogues represent historical records of mutational processes that have been active in a cell. Such processes can be distinguished by various characteristics, like mutation type, sequence context, transcriptional and replicative strand bias, genomic distribution and association with (epi)-genomic features.

11p vibransone 28-03-2024 6 2   Download

We describe a method that enables the multiplex screening of a pool of many different donor cell lines. Our method accurately predicts each donor proportion from the pool without requiring the use of unique DNA barcodes as markers of donor identity.

11p vibransone 28-03-2024 5 2   Download

CRISPR–Cas systems have provided revolutionary tools for genome editing. The discovery of Cas proteins with alternative activities has now enabled sensitive and robust tools for detecting nucleic acids. Recent reports harnessing these new CRISPR–Cas technologies display their potential for providing lowcost and practical diagnostic tools for pathogen and disease detection.

4p vibransone 28-03-2024 8 2   Download

Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.

22p vibransone 28-03-2024 3 2   Download

Querying cancer genomes at single-cell resolution is expected to provide a powerful framework to understand in detail the dynamics of cancer evolution. However, given the high costs currently associated with single-cell sequencing, together with the inevitable technical noise arising from single-cell genome amplification, cost-effective strategies that maximize the quality of single-cell data are critically needed.

11p vibransone 28-03-2024 2 1   Download

Large-sequencing cancer genome projects have shown that tumors have thousands of molecular alterations and their frequency is highly heterogeneous. In such scenarios, physicians and oncologists routinely face lists of cancer genomic alterations where only a minority of them are relevant biomarkers to drive clinical decisionmaking.

11p vibransone 28-03-2024 4 2   Download

Hepatocellular carcinoma (HCC) is the one of the most common cancers and lethal diseases in the world. DNA methylation alteration is frequently observed in HCC and may play important roles in carcinogenesis and diagnosis.

11p vibransone 28-03-2024 5 2   Download

Heterotaxy (Htx) syndrome comprises a class of congenital disorders resulting from malformations in left-right body patterning. Approximately 90% of patients with heterotaxy have serious congenital heart diseases; as a result, the survival rate and outcomes of Htx patients are not satisfactory.

13p vibransone 28-03-2024 3 2   Download

The heart is one of the least regenerative organs in the human body; adult cardiac myocytes divide at extremely low frequency. Therefore, meaningful induction of cardiac regeneration requires in-depth understanding of myocyte cell-cycle control. Recent insights into how myocytes can be coaxed into duplicating in vivo might inform emerging therapeutics.

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Alzheimer’s disease (AD) is characterized by neuronal loss and astrocytosis in the cerebral cortex. However, the specific effects that pathological mutations and coding variants associated with AD have on the cellular composition of the brain are often ignored.

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